脾氨肽口服冻干粉在免疫功能失衡患者中的应用进展
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摘要
人体在疾病状态下,可出现免疫功能失衡。常见的恶性肿瘤患者、反复呼吸道感染儿童患者和哮喘患者通常存在不同程度的免疫功能失衡,而免疫功能直接影响治疗结局和疾病转归。因此,针对上述患者,在治疗原发疾病的基础上,联合应用免疫调节剂有助于调整失衡的免疫功能,改善患者预后。脾氨肽口服冻干粉是由健康动物脾脏中提取的多肽及核苷酸类物质制成的,能够增强机体细胞免疫功能,促进T细胞向有功能的分型转化,同时可刺激多种免疫分子的释放。因此,脾氨肽口服冻干粉在免疫功能失衡患者中的合理应用,有助于缩短病程,提高患者的生活质量。本文主要就脾氨肽口服冻干粉改善免疫失衡患者预后的机制、临床应用等进行综述。
Under the disease state, the immune system may have an imbalance of immune function. Patients with Common malignant tumor, children with recurrent respiratory infections, and asthma patients usually have varying degrees of immune dysfunction, and immune function directly affects outcomes of treatment and prognosis of disease. Therefore, for the above patients, combined application of immunomodulators on the basis of the treatment of primary diseases can help to adjust the imbalanced immune function and improve the prognosis of patients. Spleen aminopeptide oral freeze-dried powder is made of polypeptides and nucleotides extracted from the spleen of healthy animals, which can enhance the cellular immune function of the body, promote the transformation of T cells into functional typing, and stimulate the release of a variety of immune molecules. Therefore, the rational application of splenic aminopeptide oral freeze-dried powder in patients with immune dysfunction is helpful to shorten the course of disease and improve the quality of life. This article reviews the mechanism and clinical application of oral administration of splenic aminopeptide to improve the prognosis of patients with immune dysfunction.
Under the disease state, the immune system may have an imbalance of immune function. Patients with Common malignant tumor, children with recurrent respiratory infections, and asthma patients usually have varying degrees of immune dysfunction, and immune function directly affects outcomes of treatment and prognosis of disease. Therefore, for the above patients, combined application of immunomodulators on the basis of the treatment of primary diseases can help to adjust the imbalanced immune function and improve the prognosis of patients. Spleen aminopeptide oral freeze-dried powder is made of polypeptides and nucleotides extracted from the spleen of healthy animals, which can enhance the cellular immune function of the body, promote the transformation of T cells into functional typing, and stimulate the release of a variety of immune molecules. Therefore, the rational application of splenic aminopeptide oral freeze-dried powder in patients with immune dysfunction is helpful to shorten the course of disease and improve the quality of life. This article reviews the mechanism and clinical application of oral administration of splenic aminopeptide to improve the prognosis of patients with immune dysfunction.
引文
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[2] 唐海俊,彭慧,陈亚云.脾氨肽联合伊可新对反复呼吸道感染患儿免疫功能的影响[J].实用临床医药杂志,2018,22(19):122-124.
[3] 韩利红,李海燕,郑有光,等.脾氨肽对肺炎支原体感染致哮喘患者淋巴细胞亚群的影响研究[J].中华医院感染学杂志,2017,27(21):4857-4860.
[4] 李晓佳,路璐,杨宁,等.复可托对恶性肿瘤患者免疫功能、生活质量影响的临床观察[J].现代生物医学进展,2017,17(29):5705-5707,5680.
[5] 曹雪涛.医学免疫学[M].6版.北京:人民卫生出版社,2013:12-48.
[6] Naghavi AO,Johnstone PA,Kim S.Clinical trials exploring the benefit of immunotherapy and radiation in cancer treatment:A review of the pastand a look into the future[J].Curr Probl Cancer,2016,40(1):38-67.
[7] Germano G,Mantovani A,Allavena P.Targeting of the innate immu-nity/inflammation as complementary anti-tumor therapies[J].Ann Med,2011,43(8):581-593.
[8] Li XD,Ji M,Zheng X,et al.Evaluation of tumor response to cytokine-induced killer cells therapy in malignant solid tumors[J].J Transl Med,2014,12:215.
[9] Ilyas S,Yang JC.Landscape of Tumor Antigens in T Cell Immu-notherapy[J].J Immunol,2015,195(11):5117-5122.
[10] Zhang M,Graor H,Yan L,et al.Identification of Melanoma-reactive CD4+ T-Cell Subsets From Human Melanoma Draining Lymph Nodes[J].J Immunother,2016,39(1):15-26.
[11] Monette A,Ceccaldi C,Assaad E,et al.Chitosan thermogels for local expansion and delivery of tumor-specific T lymphocytes towards enhanced cancer immunotherapies[J].Biomaterials,2016,75:237-249.
[12] Tsun A,Miao XN,Wang CM,et al.Oncolytic Immunotherapy for Treatment of Cancer[J].Adv Exp Med Biol,2016,909:241-283.
[13] Wang L,Shen Y.Imbalance of circulating T-lymphocyte subpopu-lation in gastric cancer patients correlated with performance status[J].Clin Lab,2013,59(3/4):429-433.
[14] Netea MG,Joosten LAB,van der Meer JWM.Hypothesis:stimulation of trained immunity as adjunctive immunotherapy in cancer[J].J Leukoc Biol,2017,102(6):1323-1332.
[15] Higashi K.Antibody therapy for hematopoietic malignancies and cell surface antigen testing[J].Rinsho Byori,2014,62(4):352-358.
[16] 林立,李昌崇.儿童反复呼吸道感染判断条件和防治[J].中华实用儿科临床杂志,2017,32(4):249-252.
[17] 张华,刘莲.脾氨肽口服冻干粉治疗小儿反复呼吸道感染30例疗效研究[J].中国继续医学教育,2017,9(10):175-176.
[18] 黎海燕,邓松清,江霞辉,等.脾氨肽口服冻干粉治疗小儿呼吸系统反复感染[J].泰山医学院学报,2018,39(5):513-515.
[19] 田艳勋,郝现伟,刘丽敏,等.糖皮质激素联合脾氨肽治疗儿童过敏性鼻炎-哮喘综合征的研究[J].检验医学与临床,2018,15(10):1477-1480.
[20] Debes JD,Bohjanen PR,Boonstra A.Mechanisms of accelerated liver fibrosis progression during HIV infection[J].J Clin Transl Hepatol,2016,4(4):328-335.
[21] 何亚,李卓成.外周血T、B淋巴细胞亚群及Th1类细胞因子在乙肝肝硬化患者中的变化[J].海南医学,2017,28(17):2822-2825.