纳秒脉冲激光照射皮肤组织热力效应有限元模拟
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摘要
激光与人体皮肤组织相互作用的过程是军事、医疗等领域研究人员感兴趣的课题。基于激光与人体皮肤组织相互作用的二维轴对称有限元模型,在考虑人体皮肤组织血液灌注率和组织产热的条件下,通过温度耦合的方式,对生物传热方程和运动控制方程进行求解。利用有限元分析软件COMSOL MultiPhysics对三个纳秒激光脉冲照射皮肤组织的过程进行了数值模拟,得到了皮肤组织中的温度、位移和应力分布。由于本文脉冲激光的脉冲宽度为纳秒量级,小于皮肤组织的热迟豫时间,皮肤组织获得的热量来不及散失,脉冲激光照射近似于连续激光照射,又由于皮肤组织线弹性模拟的假设,故应力和位移呈持续增长模式。
The interaction between laser and human skin tissue is an interesting subject for researchers in military and medical fields. Based on the two-dimensional axisymmetric finite element model of the interaction between laser and human skin tissue,the bio-heat transfer equation and motion control equation are solved by temperature coupling method under the condition of considering the blood perfusion rate and heat production of human skin tissue. The finite element analysis software COMSOL Multiphysics was used to simulate the skin irradiated by three nanosecond laser pulses. The temperature,displacement and stress distribution in skin tissue were obtained. Because the pulse width of the pulsed laser is nanosecond,which is less than the thermal hysteresis time of the skin tissue,the heat gained by the skin tissue cannot be lost. The pulsed laser irradiation is similar to the continuous laser irradiation. Moreover,the stress and displacement of the skin tissue assume a continuous growth mode due to the hypothesis of linear elastic simulation.
The interaction between laser and human skin tissue is an interesting subject for researchers in military and medical fields. Based on the two-dimensional axisymmetric finite element model of the interaction between laser and human skin tissue,the bio-heat transfer equation and motion control equation are solved by temperature coupling method under the condition of considering the blood perfusion rate and heat production of human skin tissue. The finite element analysis software COMSOL Multiphysics was used to simulate the skin irradiated by three nanosecond laser pulses. The temperature,displacement and stress distribution in skin tissue were obtained. Because the pulse width of the pulsed laser is nanosecond,which is less than the thermal hysteresis time of the skin tissue,the heat gained by the skin tissue cannot be lost. The pulsed laser irradiation is similar to the continuous laser irradiation. Moreover,the stress and displacement of the skin tissue assume a continuous growth mode due to the hypothesis of linear elastic simulation.
引文
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[2]张朋波,秦颖,赵纪军,等.纳秒激光烧蚀铝材料的二维数值模拟[J].物理学报,2010,10:7120-7128.
[3]李晓霞,范世福,赵友全.激光作用下生物组织光热效应的研究现状[J].分析仪器,2003,3:44-48.
[4]张金琪,李建美,路长厚,等.激光热效应数值模拟技术研究现状[J].机电工程,2014,31:1373
[5]D.SIMHON,T.BROSH,M.HALPERN,et al.Closure of skin incisions in rabbits by laser solderingⅡ:tensile strength[J].Laser Surg,2004:12-17.
[6]孙承伟.激光辐照效应[M].北京:国防工业出版社,2002:439.
[7]黄裕年.非致命激光束武器[J].国防科技,2006,11:6-8.
[8]ROGER W.PRYOR,PhD.Mutiphysics Modelling Using COMSOL5 and MATLAB[M].MERCURY LEARNINGAND INFORMATION,2015:459-465
[9]陈燕,牛燕雄,唐芳,等.激光辐照活体皮肤层状组织的光热作用数值模拟研究[J].应用激光,2007,5:382-386.
[10]MOHIT GANGULY.Analyzing Thermal and Mechanical Effects of Pulsed Laser Irradiation on Tissues[D].Florida:Indian Institute of Technology Guwahati,2014:36.
[11]李晓霞.激光照射下生物组织热效应的数值分析与实验研究[D].天津:天津大学,2004.
[12]沈中华,袁玲,张宏超,等.固体中的激光超声[M].北京:人民邮电出版社,2015:56.
[13]H.O.TABAKOGLU,M.GULSOY.In vivo comparison of near infrared laser skin welding[J].Laser Surg,2010,3:411-421.
[14]陈燕,牛燕雄,邵琚,等.脉冲激光辐照皮肤组织的热效应解析计算研究[J].激光与红外,2009,12:1309-1312.
[15]刘全喜.强激光对材料热损伤的有限元法研究[D].成都:四川大学电子信息学院,2007.
[16]王亚伟,刘莹,卜敏,等.飞秒激光与生物组织作用原理及其应用[J].激光与红外,2008,1:7-10.
[17]牛燕雄,陈燕,唐芳.多脉冲激光辐照皮肤组织的光热效应实验研究[J].光电子·激光,2009,1:137-142.
[18]肖婧,何衡湘,夏惠军.长脉冲与连续激光联合作用下铝合金的应力场仿真[J].中国激光,2013,8:94-99.