男性甲基苯丙胺成瘾戒断者认知损伤影响因素
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摘要
目的探讨男性甲基苯丙胺(MA)成瘾戒断者认知损伤影响因素。方法选取421名男性MA成瘾戒断者,采用一般情况调查表、焦虑自评量表(SAS)、抑郁自评量表(SDS)、蒙特利尔认知评估量表(MoCA)调查MA成瘾戒断者焦虑、抑郁、认知情况。结果 249名MA成瘾戒断者存在认知损伤。二元logistic回归分析结果显示年龄、文化程度、抑郁是影响MA成瘾戒断者认知损伤的因素。结论年龄大、低学历及抑郁的男性MA成瘾戒断者易发生认知损伤,应针对不同年龄、学历的男性MA成瘾戒断者实施干预,以缓解抑郁症状,减轻认知损伤。
Objective To investigate the influence factors on cognitive impairment of male methamphetamine addicts during with-drawal. Methods A total of 421 male methamphetamine addicts were investigated. The self-designed questionnaire,SAS,SDS,MoCAwere used. Results 249 methamphetamine addicts had cognitive impairment in this study. Binary logistic regression analysis indicatedthat methamphetamine addicts' age,education,depression on cognitive impairment was significant during withdrawal. ConclusionMethamphetamine addicts with older age,lower education,and depressive symptom are more likely to suffer cognitive impairment. Inter-vention should be implemented for male methamphetamine addicts of differents ages and education to alleviate the symptoms of depres-sion and reduce cognitive impairment.
Objective To investigate the influence factors on cognitive impairment of male methamphetamine addicts during with-drawal. Methods A total of 421 male methamphetamine addicts were investigated. The self-designed questionnaire,SAS,SDS,MoCAwere used. Results 249 methamphetamine addicts had cognitive impairment in this study. Binary logistic regression analysis indicatedthat methamphetamine addicts' age,education,depression on cognitive impairment was significant during withdrawal. ConclusionMethamphetamine addicts with older age,lower education,and depressive symptom are more likely to suffer cognitive impairment. Inter-vention should be implemented for male methamphetamine addicts of differents ages and education to alleviate the symptoms of depres-sion and reduce cognitive impairment.
引文
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[18]Lauriola M,Mangiacotti A,D’Onfrio G,et al. Late-life depressionversus amnestic mild cognitive impairment:Alzheimer’s diseaseincidence in 4 years of Follow-Up[J]. Dement Geriatr Cogn Dis-ord,2018,10,46(3-4):140-153.
[19]Chan W C,Lam L C,Tam C W,et al. Neuropsychiatric symptomsare associated with increased risks of progression to dementia:a 2-year prospective study of 321 Chinese older persons with mild cog-nitive impairment[J]. Age Ageing,2011,40(1):30-35.
[2]Mathers B M,Degenhardt L,Phillips B,et al. Global epidemiology ofinjecting drug use and HIV among people who inject drug:a system-atic review[J]. Lancet,2008,372(9651):1733-1745.
[3]Su H,Tao J Y,Zhang J,et al. The effects of BDNF Val66Met genepolymorphism on serum BDNF and cognitive function in metham-phetamine-dependent patients and normal controls[J]. J Clin Psy-chopharmacol,2015,35(5):517-524.
[4]Kalechstein A D,Newton T F,Green M. Methamphetamine depend-ence is associated with neurocognitive impairement in the initial pha-ses of abstinence[J]. Neuropsychiatry Clin Neurosci,2003,15(2):215-220.
[5]Zhong N,Jiang H F,Du J,et al. The cognitive impairments and psy-chological wellbeing of methamphetamine dependent patients com-pared with health controls[J]. Prog Neuropsychopharmacol Biol Psy-chiatry,2016,69:31-37.
[6]Wang T Y,Fan T T,Bao Y P,et al. Pattern and related factors ofcognitive impairment among chronic methamphetamine users[J].The American Journal on Addiction,2017,26(2):145-151.
[7] Mosiolek A,Gierus J,Koweszko T,et al. Cognitive impairment inschizophrenia across age groups:a case-control study[J]. BMC Psy-chiatry,2016,16:37.
[8]Eraydin I E,Mueller C,Corbett A,et al. Investigating the relationshipbetween age of onset of depressive disorder and cognitive function[J]. Int J Geriatr Psychiatry,2019,34(1):38-46.
[9]Hukkelhoven C W,Rampen E W,Rampen A J,et al. Patient age andoutcome following severe traumatic brain injury:an analysis of 5600patients[J]. J Neurosurg,2003,99(4):666-673.
[10]Craik F I,Bialystok E. Cognition through the lifespan:Mechanismsof change[J]. Trends Cogn Sci,2006,10(3):131-138.
[11]Vaynman S,Ying Z,Gomez-Pinilla F. Hippocampal BDNF mediatesthe efficacy of exercise on synaptic plasticity and cognition[J]. EurJ Neurosci,2004,20(10):2580-2590.
[12]Price K L,De Santis S M,Simpson A N,et al. The impact of clinicaland demographic variables on cognitive performance in metham-phetamine dependent individuals in rural South Carolina[J]. Am JAddict,2011,20(5):447-455.
[13]Harrell P T,Mancha B E,Martins S S,et al. Cognitive performanceprofiles by latent classes of drug use[J]. Am J Addict,2014,23(5):431-439.
[14]Price K L,De Santis S M,Simpson A N,et al. The impact of clinicaland demographic variables on cognitive performance in metham-phetamine-dependent individuals in rural South[J]. Am J Addict,2011,20(5):447-455.
[15]Zhang J,Su H,Tao J,et al. Relationship of impulsivity and depres-sion during early Methamphetamine withdrawal in Han Chinesepopulation[J]. Addict Behav,2015,43:7-10.
[16]Park J H,Jung Y S,Jung Y M,et al. The role of depression in therelationship between cognitive decline and quality of life amongbreast cancer patients[J]. Support Care Cancer,2018,[Epub a-head of print].
[17]Soleimani L,Ravona-Springer R,Heymann A,et al. Depression ismore strongly associated with cognition in elderly women than menwith type 2 diabetes[J]. Int Psychogeriatr,2018,11:1-5.
[18]Lauriola M,Mangiacotti A,D’Onfrio G,et al. Late-life depressionversus amnestic mild cognitive impairment:Alzheimer’s diseaseincidence in 4 years of Follow-Up[J]. Dement Geriatr Cogn Dis-ord,2018,10,46(3-4):140-153.
[19]Chan W C,Lam L C,Tam C W,et al. Neuropsychiatric symptomsare associated with increased risks of progression to dementia:a 2-year prospective study of 321 Chinese older persons with mild cog-nitive impairment[J]. Age Ageing,2011,40(1):30-35.