不同产地火绒草药材及其生长土壤中重金属含量研究
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摘要
目的:该文主要对辽宁地区火绒草药材及其生长土壤中的重金属含量进行评价研究,为建立火绒草药材的质量评价标准及安全用药提供参考依据。方法:对17个地区火绒草样本及土壤进行测定。采用电感藕合等离子质谱(ICP-MS)法、原子分光光度法和原子荧光光谱法对药材中及产地土壤中铅、砷、汞、镉、铜进行测定。结果:辽宁省本溪、鞍山、大连产地以及河北产地火绒草药材铅元素含量超出标准,多数产地火绒草药材中镉元素含量超出标准;土壤中只有汞元素含量超出标准。结论:火绒草重金属含量基本达到《药用植物及制剂出口绿色行业标准》的相应要求,土壤中重金属含量也能达到国家土壤环境质量标准。但部分产地野生火绒草中铅与镉重金属含量超出标准,这与药材的生长环境、采收加工等因素密切相关,因此应选择生长环境中铅与镉含量较低的地区进行药材的采摘或规范化种植与加工。
Objective To analyze samples of L. leontopodioides collected from different geographical areas of Liaoning and determinate the content of heavy metals in herbs and soil;put forward the quality evaluation standard;provide reliable basis for safe medication. Methods:The herb samples and soil samples from 17 production areas were measured. ICP-MS,AAS and AES were used to measure the content of Pb,Cd,Cu,Hg,As in herb and soil. Results:The contents of Pb in L. leontopodioides from Benxi,Anshan,Dalian of Liaoning province and Hebei province exceeded by the standard;the contents of Cd in L. leontopodioides from most areas were higher than the standard. Only the contents of Hg in the soil exceeded the standard. Conclusion:The contents of heavy metals in L. leontopodioides met the requirements of Green Industry Standard for the Export of Medicinal Plants and Preparations,and the contents of heavy metals in soil could meet the national soil environmental quality standard. But the contents of Pb and Cd in herbs from part of the areas exceeded the standard,and it was closely related to the growth environment,harvest processing and other factors. Therefore,it is necessary to select the areas with low Pb and Cd in the growth environment to harvest or standardize the planting and processing.
Objective To analyze samples of L. leontopodioides collected from different geographical areas of Liaoning and determinate the content of heavy metals in herbs and soil;put forward the quality evaluation standard;provide reliable basis for safe medication. Methods:The herb samples and soil samples from 17 production areas were measured. ICP-MS,AAS and AES were used to measure the content of Pb,Cd,Cu,Hg,As in herb and soil. Results:The contents of Pb in L. leontopodioides from Benxi,Anshan,Dalian of Liaoning province and Hebei province exceeded by the standard;the contents of Cd in L. leontopodioides from most areas were higher than the standard. Only the contents of Hg in the soil exceeded the standard. Conclusion:The contents of heavy metals in L. leontopodioides met the requirements of Green Industry Standard for the Export of Medicinal Plants and Preparations,and the contents of heavy metals in soil could meet the national soil environmental quality standard. But the contents of Pb and Cd in herbs from part of the areas exceeded the standard,and it was closely related to the growth environment,harvest processing and other factors. Therefore,it is necessary to select the areas with low Pb and Cd in the growth environment to harvest or standardize the planting and processing.
引文
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[19]王锦芳,王纯健.金银花药材中重金属铅、镉含量分析[J].海峡药学,2010,22(10):72-74.
[20]谭忠谋,杨帆,韦升坚. 5种常见中草药中有害元素铅、镉、铜的含量测定与分析[J].中南药学,2011,09(11):844-847.
[2]Q ChuLu,W En,Q Li,et al. Ent-kaurene diterpenoids and lignan from Leontopodium leontopodioides and their inhibitory activities against cyclooxygenases-1 and 2[J]. Phytochemistry Letters,2017(21):94-97.
[3]XYangYang,XHaiHui,ZLi,etal.Acylflavone and lignan glucosides from Leontopodium leontopodioides[J].Phytochemistry Letters,2016(17):247-250.
[4]LXin,LJianGuang,WXiaoBing,etal.Phenolicsfrom Leontopodium leontopodioides inhibiting nitric oxide production[J].Fitoterapia,2012,83:883-887.
[5]伍义行,王建国,谢家声,等.火绒草的研究进展[J].中草药,2000,31(1):64-66.
[6]张新刚,李婷,任新蕊,等.火绒草属药学研究新进展[J].安徽农业科学,2011,39(31):19093-19094.
[7]刘英佶,姜鸿,康廷国,等.火绒草研究概况[J].辽宁中医药大学学报,2010,12(8):46-48.
[8]陈晋红.中药材重金属和农药残留的研究进展[J].中药新药与临床药理,2009,28(2):187-190.
[9]刘毅,邱昌贾.中药中重金属研究综述[J].微量元素与健康研究,2008,25(4):56-58.
[10]王刚,陈荣达,林炳承.中药中微量元素测定的研究进展[J].药物分析杂志,2002,22(2):151-152.
[11]金航,崔秀明,徐珞珊,等.三七道地药材与非道地药材及土壤微量元素分析[J].云南大学学报(自然科学版),2006,28(2):144-146.
[12]左甜甜,李耀磊,陈沛.西洋参、山楂/枸杞子中重金属及有害元素残留量测定及初步风险评估[J].药物分析杂志,2016,36(11):2019-2014.
[13]林龙勇,于冰冰,廖晓勇,等.三七及其中药制剂中砷和重金属含量及健康风险评估[J].生态毒理学报,2013,8(2):244-246.
[14]刘毅,邱昌贵.中药中重金属研究综述[J].微量元素与健康研究,2008,25(25):56-58.
[15]易桂花,彭培好.川产道地药材川芎中重金属的来源途径研究[J].安徽农业科学,2007,35(33):10744-10745.
[16]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015.
[17]中华人民共和国商务部. WM/T2-2004药用植物及制剂外经贸行业标准[S].北京:中国标准出版社,2004:1-2.
[18]中华人民共和国农业部. NY/T391-2000绿色食品产地生态环境质量标准[S].北京:中国标准出版社,2000:4.
[19]王锦芳,王纯健.金银花药材中重金属铅、镉含量分析[J].海峡药学,2010,22(10):72-74.
[20]谭忠谋,杨帆,韦升坚. 5种常见中草药中有害元素铅、镉、铜的含量测定与分析[J].中南药学,2011,09(11):844-847.