超声弹性成像在乳腺肿瘤诊断中的应用价值及与p53、C-erb B-2、Ki-67蛋白相关性研究
|
摘要
目的:探讨超声弹性成像在乳腺肿瘤患者中的诊断应用价值及对p53、C-erbB-2、Ki-67蛋白的相关性。方法:选取2014年12月至2016年10月医院收治乳腺肿瘤患者65例,共73个病灶,患者均行超声弹性成像和常规超声检查,并且将获得的病理组织采用免疫组织化学法完成p53、C-erbB-2、Ki-67蛋白表达检测,分析超声弹性成像参数在乳腺肿瘤患者中的诊断应用价值及对p53、C-erbB-2、Ki-67蛋白表达的影响。结果:65例患者最终均经过手术病理检查得到确诊,共有73个病灶。恶性肿瘤常规超声及超声弹性成像诊断符合率,高于良性肿瘤(P<0.05);超声弹性成像参数良性肿瘤、恶性肿瘤诊断符合率,高于常规超声(P<0.05);恶性肿瘤p53、C-erbB-2、Ki-67蛋白阳性率,高于良性肿瘤(P<0.05);超声弹性成像中内部回声、毛刺、血供0-1级及淋巴结转移与p53、C-erbB-2、Ki-67蛋白表达阳性率呈负相关性(P<0.05)。结论:将超声弹性成像参数用于乳腺肿瘤良、恶性鉴别中效果理想,且超声弹性成像参数与细胞蛋白具有提示作用。
Objective: To investigate the diagnostic application value of ultrasound elastography in patients with breast cancer and its correlation with p53, C-erbB-2 and Ki-67 proteins. Methods: 65 patients with breast tumors received and treated by our hospital from December 2014 to October 2016 were used as research objects. There were a total of 73 lesions. All patients received the ultrasound elastography and routine ultrasound examination. The expression of p53, C-erbB-2 and Ki-67 proteins were detected by immunohistochemistry for the pathological tissues obtained. The diagnostic value of parameters of ultrasound elastography in patients with breast tumors and its effect on the expression of p53, C-erbB-2 and Ki-67 proteins were analyzed. Results: 65 patients were confirmed by surgical pathologic examination. There were 73 lesions in total. The coincidence rate of conventional ultrasound and ultrasound elastography in diagnosis of malignant tumors was higher than that of benign tumors(P <0.05); the coincidence rate of ultrasound elastography parameters in diagnosis of benign tumors and malignant tumors was higher than that of conventional ultrasound(P <0.05); the positive rate of p53, C-erbB-2 and Ki-67 proteins in malignant tumors was higher than that of benign tumors(P <0.05); and internal echo, burr, blood supply Grade 0-1 and lymph node metastasis were negatively correlated with the positive rates of expression of p53, C-erbB-2 and Ki-67 proteins(P <0.05). Conclusion: Ultrasound elastography parameters can be used to differentiate benign and malignant breast tumors with satisfactory results. Ultrasound elastography parameters and cellular proteins have a suggestive effect.
Objective: To investigate the diagnostic application value of ultrasound elastography in patients with breast cancer and its correlation with p53, C-erbB-2 and Ki-67 proteins. Methods: 65 patients with breast tumors received and treated by our hospital from December 2014 to October 2016 were used as research objects. There were a total of 73 lesions. All patients received the ultrasound elastography and routine ultrasound examination. The expression of p53, C-erbB-2 and Ki-67 proteins were detected by immunohistochemistry for the pathological tissues obtained. The diagnostic value of parameters of ultrasound elastography in patients with breast tumors and its effect on the expression of p53, C-erbB-2 and Ki-67 proteins were analyzed. Results: 65 patients were confirmed by surgical pathologic examination. There were 73 lesions in total. The coincidence rate of conventional ultrasound and ultrasound elastography in diagnosis of malignant tumors was higher than that of benign tumors(P <0.05); the coincidence rate of ultrasound elastography parameters in diagnosis of benign tumors and malignant tumors was higher than that of conventional ultrasound(P <0.05); the positive rate of p53, C-erbB-2 and Ki-67 proteins in malignant tumors was higher than that of benign tumors(P <0.05); and internal echo, burr, blood supply Grade 0-1 and lymph node metastasis were negatively correlated with the positive rates of expression of p53, C-erbB-2 and Ki-67 proteins(P <0.05). Conclusion: Ultrasound elastography parameters can be used to differentiate benign and malignant breast tumors with satisfactory results. Ultrasound elastography parameters and cellular proteins have a suggestive effect.
引文
[1]丁堪铄,卢丽娜,余莉萍,等.C-erbB-2、p53、Ki-67、ER、PR在子宫内膜癌中的表达及临床相关性[J].实用医学杂志,2015,31(24):4069-4071.
[2]胡晓丹,肖蓉,杨昭晖.超声弹性成像应变率比值法与改良5分法在乳腺良恶性肿瘤中的诊断价值[J].中国医学影像学杂志,2016,24(12):900-902.
[3]胡彦,徐超丽,杨斌.超声弹性成像定量参数对乳腺实性肿块的鉴别诊断分析[J].医学研究生学报,2016,29(8):836-840.
[4]吴朝贵,底炜.彩色多普勒超声及弹性成像诊断乳腺癌的应用价值[J].中国超声医学杂志,2015,31(9):844-846.
[2]胡晓丹,肖蓉,杨昭晖.超声弹性成像应变率比值法与改良5分法在乳腺良恶性肿瘤中的诊断价值[J].中国医学影像学杂志,2016,24(12):900-902.
[3]胡彦,徐超丽,杨斌.超声弹性成像定量参数对乳腺实性肿块的鉴别诊断分析[J].医学研究生学报,2016,29(8):836-840.
[4]吴朝贵,底炜.彩色多普勒超声及弹性成像诊断乳腺癌的应用价值[J].中国超声医学杂志,2015,31(9):844-846.