摘要
近几十年,全球范围内儿童支气管哮喘的发病率呈增长趋势。环境烟草烟雾(ETS)暴露是儿童呼吸道疾病,特别是支气管哮喘发生的危险因素。围生期ETS暴露可以损伤肺功能、改变免疫状态,增加儿童支气管哮喘发生。本文综述ETS暴露对儿童哮喘的影响及机制,胎儿期及儿童期ETS暴露对支气管儿童呼吸道健康的影响,并介绍ETS暴露的标志物研究进展。
In the past few decades, the prevalence of bronchial asthma in children has increased abruptly worldwide. Environmental tobacco smoke(ETS) exposure is a risk factor for respiratory diseases in children, especially bronchial asthma. ETS exposure during prenatal and postnatal life can impair lung development, alter the immune system, and increase the prevalence of bronchial asthma in children. This review describes the effects and mechanisms of ETS on bronchial asthma, and the effects of ETS exposure on the lung health in children and fetal period, and the biomarkers of ETS exposure.
引文
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