头孢类抗生素的热分解动力学研究
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摘要
采用热重分析法详细研究了头孢克肟和头孢喹肟两种头孢类抗生素的热稳定性及热分解过程,利用Kissinger法和Ozawa-Flynn-Wall法计算出两种抗生素的热分解动力学参数,Ea和lnA等。利用红外光谱分析了两种抗生素分解前后发生的结构变化。结果表明,Kissinger法和Ozawa-Flynn-Wall法计算得到的头孢克肟的E_a分别为39. 18 kJ/mol和41. 91 kJ/mol,ln A为8. 46 s~(-1);头孢喹肟的E_a分别为27. 32 kJ/mol和28. 91 kJ/mol,lnA为19. 4 s~(-1)。头孢克肟的分解活化能E_a高于头孢喹肟,说明其热稳定性优于后者。
The thermal stability and decomposition process of cefixime and cefquinoxime were studied in detail by thermogravimetric analysis. Kissinger method and Ozawa-Flynn-Wall method were used to calculate the thermal decomposition kinetic parameters of these two cephalosporins,including Ea and lnA. The possible structural changes of the two antibiotics before and after decomposition were analyzed by infrared spectroscopy. The results showed that Ea of the cefixime calculated by Kissinger method and Ozawa-Flynn-Wall method were 39. 18 kJ/mol and 41. 91 kJ/mol,respectively,and lnA was 8. 46 s~(-1). Ea of the cefixime was 27. 32 kJ/mol and 28. 91 kJ/mol,respectively,and lnA was 19. 4 s~(-1). The decomposition activation energy of cefixime was higher than cefquinoxime,indicating that its thermal stability was better than that of cefquinoxime.
The thermal stability and decomposition process of cefixime and cefquinoxime were studied in detail by thermogravimetric analysis. Kissinger method and Ozawa-Flynn-Wall method were used to calculate the thermal decomposition kinetic parameters of these two cephalosporins,including Ea and lnA. The possible structural changes of the two antibiotics before and after decomposition were analyzed by infrared spectroscopy. The results showed that Ea of the cefixime calculated by Kissinger method and Ozawa-Flynn-Wall method were 39. 18 kJ/mol and 41. 91 kJ/mol,respectively,and lnA was 8. 46 s~(-1). Ea of the cefixime was 27. 32 kJ/mol and 28. 91 kJ/mol,respectively,and lnA was 19. 4 s~(-1). The decomposition activation energy of cefixime was higher than cefquinoxime,indicating that its thermal stability was better than that of cefquinoxime.
引文
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[2]郭慧卿,成日青,陈建平,等.布洛芬热分解及其动力学研究[J].广州化工,2015,43(7):100-102.
[3]曹亚蒙,周彩荣,刘中平.葡萄糖酸亚锡热分解动力学[J].郑州大学学报,2015,47(3):77-81.
[4]陈永顺,杜世明.热分析法在药学领域中的应用进展[J].中国药房,2005,16(20):1583-1584.
[5]刘振海.分析化学手册:热分析[M].北京:化学工业出版社,2002:4861.
[6]赵龙山,李清,陈晓辉,等.头孢呋辛钠的热稳定性及其热分解动力学研究[J].中国药房,2012,23(33):3081-3083.