系统评价热毒宁注射液治疗毛细支气管炎的疗效与安全性
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摘要
目的分析研究热毒宁注射液在治疗毛细支气管炎中的作用和安全性。方法利用随机数字表法,将入院的毛细支气管炎患者均分为2组,观察组59例,在常规西药治疗基础上给予热毒宁注射液进行治疗;对照组59例,采用常规西药方法进行治疗。对比记录两组毛细支气管炎患者治疗的总有效率、症状改善时间和治疗后的炎症因子水平。结果 (1)两组患儿治疗的总有效率对比:观察组患儿治疗的总有效率(98.31%)显著高于对照组(86.44%)(P<0.05),差异有统计学意义;(2)两组患儿的症状改善时间对比:观察组患儿的咳嗽缓解时间(3.10±0.46)d显著少于对照组(4.88±0.97)d(P<0.05);观察组患儿的喘鸣音消失时间(1.07±0.36)d显著少于对照组(2.36±0.45)d(P<0.05),差异有统计学意义;(3)两组患儿治疗后的炎症因子水平比较:治疗后,观察组患儿的炎症因子水平(12.10±0.95)mg/L显著低于对照组(17.45±1.30)mg/L(P<0.05),差异有统计学意义。结论给予毛细支气管炎患者常规治疗基础上加入热毒宁注射液,可以高效提升患者的治疗总有效率,帮助患者明显改善不良症状,使身体得到稳定的恢复,具有显著的临床作用。
Objective To analyze the role and safety of Reduning injection in the treatment of bronchiolitis. Methods Patients with bronchiolitis admitted to hospital were divided into 2 groups by random number table method. 59 patients in the observation group were treated with Reduning injection on the basis of conventional western medicine. 59 patients in the control group were treated with conventional western medicine. The method is treated. The total effective rate of treatment, the time of symptom improvement and the level of inflammatory factors after treatment were recorded in the two groups. Results(1) The total effective rate of treatment in the two groups: the total effective rate of the treatment group(98.31%) was significantly higher than that of the control group(86.44%)(P<0.05), the difference was statistically significant;(2) Comparison of symptom improvement time between the two groups: the cough remission time(3.10±0.46) d of the observation group was significantly less than that of the control group(4.88±0.97) d(P<0.05); the wheezing sound of the observation group disappeared. The time(1.07±0.36)d was significantly less than that of the control group(2.36±0.45)d(P<0.05), and the difference was statistically significant.(3) Comparison of inflammatory factors after treatment in the two groups: after treatment, the level of inflammatory factors in the observation group(12.10 +0.95) mg/l was significantly lower than that in the control group(17.45+1.30) mg/L(P<0.05), and the difference was statistically significant. Conclusion The routine treatment of patients with bronchiolitis added Reduning injection can effectively improve the total effective rate of treatment of patients, help patients to significantly improve the symptoms, and achieve a stable recovery of the body, with a significant clinical effect.
Objective To analyze the role and safety of Reduning injection in the treatment of bronchiolitis. Methods Patients with bronchiolitis admitted to hospital were divided into 2 groups by random number table method. 59 patients in the observation group were treated with Reduning injection on the basis of conventional western medicine. 59 patients in the control group were treated with conventional western medicine. The method is treated. The total effective rate of treatment, the time of symptom improvement and the level of inflammatory factors after treatment were recorded in the two groups. Results(1) The total effective rate of treatment in the two groups: the total effective rate of the treatment group(98.31%) was significantly higher than that of the control group(86.44%)(P<0.05), the difference was statistically significant;(2) Comparison of symptom improvement time between the two groups: the cough remission time(3.10±0.46) d of the observation group was significantly less than that of the control group(4.88±0.97) d(P<0.05); the wheezing sound of the observation group disappeared. The time(1.07±0.36)d was significantly less than that of the control group(2.36±0.45)d(P<0.05), and the difference was statistically significant.(3) Comparison of inflammatory factors after treatment in the two groups: after treatment, the level of inflammatory factors in the observation group(12.10 +0.95) mg/l was significantly lower than that in the control group(17.45+1.30) mg/L(P<0.05), and the difference was statistically significant. Conclusion The routine treatment of patients with bronchiolitis added Reduning injection can effectively improve the total effective rate of treatment of patients, help patients to significantly improve the symptoms, and achieve a stable recovery of the body, with a significant clinical effect.
引文
[1]李佳,欧敏,许珊,等.热毒宁注射液治疗毛细支气管炎的疗效与安全性系统评价[J].转化医学杂志,2016,5(2):106-111.
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[5]张智敏.热毒宁联合如意金黄散穴位贴敷治疗小儿毛细支气管炎的疗效[J].牡丹江医学院学报,2016,37(3):72-74.
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[9]于俊香.热毒宁注射液联合治疗小儿发热、急性支气管炎40例临床观察[J].农垦医学,2017,39(3):256-258.
[10]洪德鑫.热毒宁注射液联合沐舒坦雾化吸入治疗老年慢性支气管炎急性发作临床研究[J].海峡药学,2016,28(5):129-130.
[11]胡玥.热毒宁注射液的药理作用及抗病毒作用[J].临床合理用药杂志,2016,9(7):174-176.
[12]康丹瑜,耿婷,丁岗,等.热毒宁注射液临床联用及药物相互作用的研究进展[J].中国药房,2017,28(2):276-279.
[13]葛雯,李海波,于洋,等.热毒宁注射液化学成分、药理作用及临床应用研究进展[J].中草药,2017,48(5):1027-1036.
[14]郭亚波.热毒宁注射液治疗小儿支气管肺炎80例[J].中国中医药现代远程教育,2016,14(5):49-50.
[15]赵慧,王丽,冷红春,等.热毒宁注射液治疗小儿胃肠型上呼吸道感染的效果观察[J].中华医院感染学杂志,2016,26(11):2581-2583.
[2]宋煜霞,李学峰.热毒宁注射液治疗毛细支气管炎的临床分析[J].临床医药文献电子杂志,2016,3(21):4298-4299.
[3]徐景利,连宝涛,梁峥嵘,等.热毒宁注射液治疗小儿毛细支气管炎的Meta分析[J].中成药,2016,38(4):763-769.
[4]唐艳.热毒宁注射液对小儿毛细支气管炎的疗效[J].海峡药学,2017,29(1):112-113.
[5]张智敏.热毒宁联合如意金黄散穴位贴敷治疗小儿毛细支气管炎的疗效[J].牡丹江医学院学报,2016,37(3):72-74.
[6]丁明.热毒宁注射液佐治毛细支气管炎疗效观察[J].中国临床新医学,2016,9(8):732-733.
[7]赵晓燕.研究喜炎平注射液治疗毛细支气管炎的临床效果[J].中国现代药物应用,2016,10(8):134-135.
[8]岳焕荣.热毒宁注射液治疗病毒性急性气管-支气管炎的临床治疗效果[J].中国医药指南,2016,14(24):198.
[9]于俊香.热毒宁注射液联合治疗小儿发热、急性支气管炎40例临床观察[J].农垦医学,2017,39(3):256-258.
[10]洪德鑫.热毒宁注射液联合沐舒坦雾化吸入治疗老年慢性支气管炎急性发作临床研究[J].海峡药学,2016,28(5):129-130.
[11]胡玥.热毒宁注射液的药理作用及抗病毒作用[J].临床合理用药杂志,2016,9(7):174-176.
[12]康丹瑜,耿婷,丁岗,等.热毒宁注射液临床联用及药物相互作用的研究进展[J].中国药房,2017,28(2):276-279.
[13]葛雯,李海波,于洋,等.热毒宁注射液化学成分、药理作用及临床应用研究进展[J].中草药,2017,48(5):1027-1036.
[14]郭亚波.热毒宁注射液治疗小儿支气管肺炎80例[J].中国中医药现代远程教育,2016,14(5):49-50.
[15]赵慧,王丽,冷红春,等.热毒宁注射液治疗小儿胃肠型上呼吸道感染的效果观察[J].中华医院感染学杂志,2016,26(11):2581-2583.