非小细胞肺癌中医证候诊断量表的研制
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摘要
目的:通过建立非小细胞肺癌(non-small cell lung cancer,NSCLC)中医证候诊断量表,为中医辨证分型提供理论依据,指导非小细胞肺癌的临床治疗。方法:通过检索NSCLC中医证候学和症状学的相关文献,以及临床患者访谈,初步确定NSCLC中医证候诊断量表条目池,根据专家、患者对各条目的重要性评价结果,确定条目。选取河南中医药大学第一附属医院、河南省肿瘤医院正在接受治疗的NSCLC患者进行调查,经统计分析后,得出中医证候量表。结果:通过对条目池筛选及专家、患者的评价,初步确定23个条目,制定NSCLC中医证候诊断量表。结论:本研究建立的NSCLC中医证候诊断量表具有良好的信效度,为治疗方案和指导临床用药提供了依据。
Objective: To provide theoretical basis for TCM syndrome differentiation,and guide the clinical treatment of non-small cell lung cancer( NSCLC) through the establishment of NSCLC TCM syndrome diagnosis scale. Methods: By searching the relevant literature of TCM syndromes and symptoms of NSCLC and interviewing clinical patients,the item pool of TCM syndromes diagnosis scale of NSCLC was preliminarily determined. According to the evaluation results of experts and patients on the importance of each item,the item pool was determined. The NSCLC patients who were being treated in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine and Henan Cancer Hospital were investigated. After statistical analysis,the TCM Syndrome Scale was obtained. Results: Through item pool screening and evaluation of experts and patients,23 items were initially identified and NSCLC TCM syndrome diagnosis scale was developed. Conclusion: The NSCLC TCM Syndrome Diagnostic Scale established in this study has good reliability and validity,which provides a basis for the treatment plan and guidance of clinical medication.
Objective: To provide theoretical basis for TCM syndrome differentiation,and guide the clinical treatment of non-small cell lung cancer( NSCLC) through the establishment of NSCLC TCM syndrome diagnosis scale. Methods: By searching the relevant literature of TCM syndromes and symptoms of NSCLC and interviewing clinical patients,the item pool of TCM syndromes diagnosis scale of NSCLC was preliminarily determined. According to the evaluation results of experts and patients on the importance of each item,the item pool was determined. The NSCLC patients who were being treated in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine and Henan Cancer Hospital were investigated. After statistical analysis,the TCM Syndrome Scale was obtained. Results: Through item pool screening and evaluation of experts and patients,23 items were initially identified and NSCLC TCM syndrome diagnosis scale was developed. Conclusion: The NSCLC TCM Syndrome Diagnostic Scale established in this study has good reliability and validity,which provides a basis for the treatment plan and guidance of clinical medication.
引文
[1]陈嘉璐,李湧健.中医药治疗晚期非小细胞肺癌临床观察[J].中医学报,2017,32(5):711-714.
[2] CHEN W,ZHENG R,BAADE P D,et al,Cancer statistics in Chi-na[J]. CA Cancer J Clin,2016,66(2):115-132.
[3]中华医学会呼吸病学分会肺癌学组.晚期非小细胞肺癌分子靶向治疗专家共识[J].中华结核和呼吸杂志,2014,37(3):177-182.
[4]任娟,翟笑枫.原发性肝癌中医证候诊断量表的研制[J].中国全科医学,2018,21(5):574-579.
[5]关秋红,武维屏.从病、证、症辨治肺癌探析[J].中医杂志,2016,57(10):884-886.
[6]陈娟,顾俊菲,汪春飞,等.组分结构中药与网络药理学:病理机制网络的系统整体调控[J].中国中药杂志,2015,40(4):758-764.
[7]王碧娟,葛巧.中西医结合治疗非小细胞肺癌临床观察[J].新中医,2016,48(10):163-165.
[8]谢洋,王佳佳,赵虎雷,等.基于病证结合特发性肺纤维化患者报告结局量表概念框架的初步构建[J].中医学报,2016,31(7):953-956.
[9]高天琦,陈芝强,林丽珠,等.益气除痰法对晚期非小细胞肺癌患者生存期影响的Meta分析[J].中医学报,2017,33(8):1383-1387.
[10]岳敏.类风湿性关节炎患者报告结局的中医量表条目初筛[J].河南中医,2017,37(10):1780-1782.
[11]杨秦梅,崔青荣,李彬,等.和胃扶正三联疗法治疗非小细胞肺癌化疗相关性恶心呕吐临床观察[J].新中医,2018,50(6):176-179.
[12]陈文军,田菲,许冬鑫,等.非小细胞肺癌患者预后影响因素与中医体质类型的相关性[J].中医杂志,2015,56(18):1569-1572.
[13]张立力,臧瑜. MD安德森症状评估量表肺癌模块的修订和考评[J].肿瘤,2013,33(5):434-438.
[14]李志营,于欣,马燕桃,等.运用德尔菲法对双极性指数评估表适用性的调查[J].中国神经精神疾病杂志,2014,40(2):102-105.
[15]刘苓霜,刘嘉湘,沈丽萍,等.中医辨证治疗对晚期非小细胞肺癌巩固治疗的影响[J].中医杂志,2015,56(17):1473-1477.
[16]白伟,韩永波,朱冬梅,等.中药治疗肺癌用药情况分析[J].中医学报,2017,32(3):335-338.
[17]姚丹霓,何泽慧,谢秀丽,等.寻常型银屑病主症量表条目池筛选的专家问卷调查[J].广州中医药大学学报,2016,33(2):270-271.
[18]何庆勇,王阶,张允岭,等.基于患者报告的临床结局评价量表的条目筛选方法[J].中华中医药杂志,2011,26(1):112-114.
[19]周峰,周庆伟,崔青荣.中医治疗肺癌骨转移疼痛综述[J].河南中医,2018,38(1):159-162.
[20]李超,王苗苗,姜枫,等.原发性高血压病肝气郁结证诊断量表条目筛选及检验[J].时珍国医国药,2017,28(10):2560-2562.
[21]谈馨媛,路枝红,吴蕾,等.刘伟胜教授辨治肺癌的经验整理[J].时珍国医国药,2013,24(12):3032-3034.
[22]臧凝子,庞立健,李品,等.运用量表常模工具建立证候量化分级标准的思维探析[J].中华中医药杂志,2017,32(6):2591-2594.
[23]关秋红,武维屏.从肝论治肺癌十法[J].现代中医临床,2015,22(6):47-49.
[24]王保芹,王心恒,李泽庚.中医药治疗肺癌研究进展[J].中医学报,2018,33(3):371-374.
[25]李丛煌,刘瑞,郑红刚,等.晚期非小细胞肺癌中医证候分布及动态演变临床研究[J].中医学报,2015,30(8):1085-1088.
[26]董静波,卢晓峰,翁国爱,等.肺癌患者中医体质及辨证分型与临床TNM分期及病理类型的相关性研究[J].中国中医药科技,2016,23(5):506-508.
[27]李蓉,焦丽静,许玲.非小细胞肺癌的中医证型分布规律[J].上海中医药杂志,2012,46(9):95-97.
[2] CHEN W,ZHENG R,BAADE P D,et al,Cancer statistics in Chi-na[J]. CA Cancer J Clin,2016,66(2):115-132.
[3]中华医学会呼吸病学分会肺癌学组.晚期非小细胞肺癌分子靶向治疗专家共识[J].中华结核和呼吸杂志,2014,37(3):177-182.
[4]任娟,翟笑枫.原发性肝癌中医证候诊断量表的研制[J].中国全科医学,2018,21(5):574-579.
[5]关秋红,武维屏.从病、证、症辨治肺癌探析[J].中医杂志,2016,57(10):884-886.
[6]陈娟,顾俊菲,汪春飞,等.组分结构中药与网络药理学:病理机制网络的系统整体调控[J].中国中药杂志,2015,40(4):758-764.
[7]王碧娟,葛巧.中西医结合治疗非小细胞肺癌临床观察[J].新中医,2016,48(10):163-165.
[8]谢洋,王佳佳,赵虎雷,等.基于病证结合特发性肺纤维化患者报告结局量表概念框架的初步构建[J].中医学报,2016,31(7):953-956.
[9]高天琦,陈芝强,林丽珠,等.益气除痰法对晚期非小细胞肺癌患者生存期影响的Meta分析[J].中医学报,2017,33(8):1383-1387.
[10]岳敏.类风湿性关节炎患者报告结局的中医量表条目初筛[J].河南中医,2017,37(10):1780-1782.
[11]杨秦梅,崔青荣,李彬,等.和胃扶正三联疗法治疗非小细胞肺癌化疗相关性恶心呕吐临床观察[J].新中医,2018,50(6):176-179.
[12]陈文军,田菲,许冬鑫,等.非小细胞肺癌患者预后影响因素与中医体质类型的相关性[J].中医杂志,2015,56(18):1569-1572.
[13]张立力,臧瑜. MD安德森症状评估量表肺癌模块的修订和考评[J].肿瘤,2013,33(5):434-438.
[14]李志营,于欣,马燕桃,等.运用德尔菲法对双极性指数评估表适用性的调查[J].中国神经精神疾病杂志,2014,40(2):102-105.
[15]刘苓霜,刘嘉湘,沈丽萍,等.中医辨证治疗对晚期非小细胞肺癌巩固治疗的影响[J].中医杂志,2015,56(17):1473-1477.
[16]白伟,韩永波,朱冬梅,等.中药治疗肺癌用药情况分析[J].中医学报,2017,32(3):335-338.
[17]姚丹霓,何泽慧,谢秀丽,等.寻常型银屑病主症量表条目池筛选的专家问卷调查[J].广州中医药大学学报,2016,33(2):270-271.
[18]何庆勇,王阶,张允岭,等.基于患者报告的临床结局评价量表的条目筛选方法[J].中华中医药杂志,2011,26(1):112-114.
[19]周峰,周庆伟,崔青荣.中医治疗肺癌骨转移疼痛综述[J].河南中医,2018,38(1):159-162.
[20]李超,王苗苗,姜枫,等.原发性高血压病肝气郁结证诊断量表条目筛选及检验[J].时珍国医国药,2017,28(10):2560-2562.
[21]谈馨媛,路枝红,吴蕾,等.刘伟胜教授辨治肺癌的经验整理[J].时珍国医国药,2013,24(12):3032-3034.
[22]臧凝子,庞立健,李品,等.运用量表常模工具建立证候量化分级标准的思维探析[J].中华中医药杂志,2017,32(6):2591-2594.
[23]关秋红,武维屏.从肝论治肺癌十法[J].现代中医临床,2015,22(6):47-49.
[24]王保芹,王心恒,李泽庚.中医药治疗肺癌研究进展[J].中医学报,2018,33(3):371-374.
[25]李丛煌,刘瑞,郑红刚,等.晚期非小细胞肺癌中医证候分布及动态演变临床研究[J].中医学报,2015,30(8):1085-1088.
[26]董静波,卢晓峰,翁国爱,等.肺癌患者中医体质及辨证分型与临床TNM分期及病理类型的相关性研究[J].中国中医药科技,2016,23(5):506-508.
[27]李蓉,焦丽静,许玲.非小细胞肺癌的中医证型分布规律[J].上海中医药杂志,2012,46(9):95-97.