血清高敏C反应蛋白对吸烟人群食管癌发病的影响研究
摘要
探讨血清高敏C反应蛋白(hsCRP)对吸烟人群食管癌发病的影响。选取2015年3月至2018年2月有吸烟史来杭州市西湖区妇幼保健计划生育服务中心救治的食管癌患者为研究对象,选取86例有吸烟史的食管癌患者为研究组,同时选取有吸烟史的同期体检的非食管癌者86例为对照组。检测两组患者外周血清中hsCRP的水平,然后应用多因素logistics回归来分析血清hsCRP水平对吸烟人群食管癌发病的影响。研究组对象人群血清hsCRP的水平高于对照组(t=2.674,P=0.008),多因素logistics回归分析结果显示,患食管癌的风险hsCRP水平>3 mg/L的吸烟者高于hsCRP水平<1 mg/L的吸烟者(P<0.05)。血清hsCRP的水平与吸烟人群食管癌的患病风险密切相关,血清hsCRP的水平对筛查吸烟人群食管癌高危人群具有潜在的应用价值。
引文
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[5] 梁好.胃癌、食管癌的病因学研究和环境危险因素人群归因危险度的评价[D].北京:北京协和医学院,2012.
[6] Selby J,Prabhudesai A.Can C-reactive protein predict the severity of a post-operative complication after elective resection of colorectal cancer[J].Int J Colorectal Dis,2014,29(10):1211-1215.
[7] 梁宗潮.CA19.9与高敏C反应蛋白联合检测用于胃癌手术前后的观察[J].卫生职业教育,2012,30(22):140-141.
[8] 余新华,周晓辉,邵永生.高敏C反应蛋白水平与肺癌患病风险的病例对照研究[J].现代肿瘤医学,2018,26(5):702-704.
[9] 陈晔,李刚,谢赣生,等.高敏C反应蛋白与前列腺癌骨转移的相关性[J].中国泌尿科杂志,2016,37(10):772-776.
[10] Cavaleiro-Pinto M,Peleteiro B,Lunet N,et al.Helicobacter pylori infection and gastric cardia cancer:systematic review and meta-analysis[J].Cancer Causes Control,2011,22(3):375-387.
[11] Korniluk A,Koper O,Kemona H,et al.From inflammation to cancer[J].Ir J Med Sci,2017,186(1):57-62.
[12] 朱婕,吴寿岭,王艳秀,等.高敏C反应蛋白对新发脑出血风险的预测价值[J].中华内科杂志,2010,49(6):469-472.
[13] Lee JY,Ryu S,Cheong E,et al.Association of physical activity and inflammation with all-cause,cardiovascular-related,and cancer-related mortality[J].Mayo Clin Proc,2016,91(12):1706-1716.
[14] McSorley ST,Watt DG,Horgan PG,et al.Postoperative systemic inflammatory response,complication severity,and survival following surgery for colorectal cancer[J].Ann Surg Oncol,2016,23(9):2832-2840.
[15] Frydenberg H,Thune I,Lofter d T,et al.Pre-diagnostic high-sensitive C-reactive protein and breast cancer risk,recurrence,and survival[J].Breast Cancer Res Treat,2016,155(2):345-354.
[16] 莫晓东,蔡晓峰,李纲,等.前列腺穿刺活检患者中血清高敏C反应蛋白测定的临床意义[J].中华泌尿外科杂志,2014,35(6):461-464.
[17] 王刚,吕章艳,冯小双,等.基线高敏C-反应蛋白与吸烟人群上消化道癌发病风险的前瞻性队列研究[J].中华疾病控制杂志,2018,22(2):109-112.