摘要
背景:E-系列消退素1(Resolvin E1,RvE1)能有效抑制炎性细胞浸润、诱导巨噬细胞吞噬体内有害物质等,促进炎症消退的作用,在实验性牙周炎病理转归中的效果已经得到初步证实。目的:综述了消退素E1对牙周炎病理转归的促进作用及潜在的意义。方法:以"消退素E1,牙周炎,白细胞,血小板,活性氧,巨噬细胞,炎性因子,成骨细胞,破骨细胞"和"Resolvin E1, Periodontitis,leukocyte,platelet,reactive oxygen species,Macrophages,inflammatory factor,osteoblast,osteoclast"为关键词,检索PubMed数据库、中国生物医学文献库(CBM)和中国知识资源总库(CNKI)系列数据库1996年至2018年间收录的消退素E1与牙周炎相关文献33条,分析消退素E1对牙周炎修复和再生的研究进展。结果与结论:目前临床途径尚不能有效解决牙周组织炎性反应、不可逆性丧失等难题,迫切需要有效途径控制炎症反应、恢复牙周重建。近年来大量研究显示消退素E1在牙周炎动物及细胞模型病理转归中具有良好的效果。消退素E1作为特定G蛋白偶联受体(趋化素受体23,白三烯B4受体1)的激动剂或部分激动剂,可以引发一系列细胞特异性反应,反向调节炎症进展,将可能为牙周炎病理转归提供新的方向。
BACKGROUND: Resolvin E1 can effectively inhibit inflammatory cell infiltration and induce macrophages toswallow hazardous substances, and thus alleviates inflammation. Moreover, its effect on improving periodontitis has been preliminarily confirmed. OBJECTIVE: To review the effects of resolvin E1 on promoting the pathologic regression of periodontitis and its potential significance. METHODS: Articles addressing resolvin E1 and periodontitis published from 1996 to 2018 were retrieved from PubMed, CBM and CNKI databases. The keywords were "resolving E1, periodontitis, leukocyte, platelet, reactive oxygen species, macrophages, inflammatory factor, osteoblast, osteoclast" in English and Chinese, respectively. Thirty-three articles were included to analyze the research advance regarding resolvin E1 in the repair of periodontitis and tissue regeneration. RESULTS AND CONCLUSION: At present, the clinical therapeutic pathway cannot solve the inflammatory reaction and irreversible loss of periodontal tissue effectively, so an effective way to control the inflammatory process and treat periodontitis is urgently needed. In recent years, a large number of studies have shown that resolvin E1 has a good therapeutic effect on periodontitis in animals and cell models. Resolvin E1, as an agonist or partial agonist of specific G protein-coupled receptor(chemokine receptor 23, leukotriene B4), can trigger a series of specific responses and reverse inflammation progression, which may provide a new direction for inversing the pathology of periodontal disease.
引文
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