三七皂苷R1在心血管及神经系统疾病应用的研究进展
摘要
<正>三七的主要功效为止血、散瘀、消肿定痛。现代药理研究发现,三七含有皂苷、挥发油、三七素、黄酮、甾醇、聚炔醇、糖类、氨基酸、有机酸等多种化学成分[1]。而三七皂苷R1是诸多活性成份中的特征化合物,其含量常被用来作为判定三七质量的重要指标。三七皂苷R1的药理作用十分广泛,可以调节血压、抗动脉粥样硬化、保护心肌、改善缺血缺氧性脑病、抗脑缺血再灌注损伤、修复神经退行性病变、
引文
[1] Li BQ,Chen J,Wu TX, et al. Fast determination of four active compounds in Sanqi Panax notoginseng injection samples by high-performance liquid chromatography with a chemometric method [J].J Sep Sci,2015,38(9):1449-1457
[2] Yang Y, Xi P, Xie Y, et al.Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457[J].Int J Clin Exp Pathol, 2015,8(3):2700-2709
[3] Wang Y, Ren Y, Xing L, et al.Endothelium-dependent vasodilation effects of Panax notoginseng and its main components are mediated by nitric oxide and cyclooxygenase pathways[J].Exp Ther Med,2016,12(6):3998-4006
[4] 郭钰琪,齐冬梅,郝钰,等.三七皂苷R1调节炎性T细胞亚群保护血管内皮的实验研究[J].中国药理学通报,2012,28(2):240-244
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[6] Li LM, Liu RX, Guo JW, et al.In vivo pharmacokinetics of notoginsenoside R1 in ischemia rats after acute myocardial infarction[J].Zhong Yao Cai,2015,38(9):1908-1911
[7] 邓海英,赖为国.三七皂苷R1对急性心肌缺血大鼠模型的保护作用[J].中国实验方剂学杂志,2013,19(10):265-268
[8] 于俊民,鞠礼,王慧冬,等.三七皂苷R1对大鼠缺血心肌VEGF、bFGF 的影响[J].现代生物医学进展,2015,14(30):5845-5848
[9] Yang BR, Hong SJ, Lee SM,et al.Pro-angiogenic activity of notoginsenoside R1 in human umbilical vein endothelial cells in vitro and in a chemical-induced blood vessel loss model of zebrafish in vivo[J].Chin J Integr Med,2016,22(6):420-429
[10] He K,Yan L,Pan CS,et al.ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion -induced myocardial injury[J].Am J Physiol Heart Circ Physiol,2014,307(12):H1764-H1776
[11] Xia KP, Ca HM, Shao CZ.Protective effect of notoginsenoside R1 in a rat model of myocardial ischemia reperfusion injury by regulation of Vitamin D3 upregulated protein 1/NF-κB pathway[J].Pharmazie,2015,70(11):740-744
[12] Yu Y, Sun G, Luo Y,et al.Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways[J].Sci Rep,2016,6: 21730
[13] Ge ZR, Xu MC, Huang YU,et al.Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF-β1/TAK1 signaling pathway[J].Exp Ther Med,2016,11(6):2341-2348
[14] 万强,潘芸芸,贾钰华,等.三七皂苷R1抑制JNK通路减轻H2O2诱导心肌细胞损伤的作用[J].时珍国医国药,2015,26(9):2061-2064
[15] 周凤华,潘芸芸,贾钰华,等.Pim-2减轻H2 O2诱导乳鼠心肌细胞损伤及三七皂苷R1的干预研究[J].辽宁中医杂志,2017,44(3):618-622
[16] 周凤华,潘芸芸,崔小冰,等.ERK1/2与p38信号通路介导三七皂苷R1抗H2O2致心肌细胞损伤作用[J].中药药理与临床,2016,32(2):17-20
[17] Fang H,Yang S,Luo Y,et al.Notoginsenoside R1 inhibits vascular smooth muscle cell proliferation, migration and neointimal hyperplasia through PI3K/Akt signaling[J].Sci Rep,2018,8(1):7595
[18] Sun B, Xiao J, Sun XB, et al. Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling[J].Br J Pharmacol,2013,168(7):1758-1770
[19] Zhong L,Zhou XL,Liu YS,et al.Estrogen receptor α mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes[J].Mol Med Rep,2015,12(1): 119-126
[20] Xiao J,Zhu T,Yin YZ,et al.Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE-/- mice[J].Eur J Pharmacol,2018,833:441-450
[21] Wang Y,Tu L,Li Y,et al.Notoginsenoside R1 protects against neonatal cerebral hypoxic-ischemic injury through estrogen receptor-dependent activation of endoplasmic reticulum stress pathways[J].J Pharmacol Exp Ther,2016,357(3):591-605
[22] Wang Y,Tu L,Li Y,et al.Notoginsenoside R1 alleviates oxygen-glucose deprivation/reoxygenation injury by suppressing endoplasmic reticulum calcium release via PLC[J].Sci Rep,2017,7(1):16226
[23] Tu L,Wang Y,Chen D,et al.Protective effects of notoginsenoside R1 via regulation of the PI3K-Akt-mTOR/JNK pathway in neonatal cerebral hypoxic-ischemic brain injury[J].Neurochem Res,2018,43(6):1210-1226
[24] 侯倩伶,王岩,李英博,等.三七皂苷R1通过雌激素受体调节ATF6/Akt信号通路减轻OGD/R所导致的神经元损伤[J].中国中药杂志,2017,42(6):1167-1174
[25] Zhai Y, Meng X,Luo Y,et al.Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation[J].Oncotarget,2018,9(10):9344-9363
[26] 董晓华,张成龙,吴志刚,等.三七皂苷R1对大鼠脑缺血再灌注损伤的保护作用[J].中国老年学杂志,2015,35(7):1940-1942
[27] 赵志新,胡小铭,汪杰,等.三七皂苷R1对大鼠脑缺血-再灌注损伤后TNF-αmRNA 的影响[J].浙江创伤外科,2017,22(1):13-16
[28] Meng X,Wang M,Wang X,et al.Suppression of NADPH oxidaseand mitochondrion-derived superoxide by notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt /Nrf2 pathways[J].Free Radic Res,2014,48(7): 823-838
[29] Zou S,Zhang M,Feng L,et al.Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats[J].Exp Ther Med,2017,14(6):6012-6016
[30] 张鑫,林永文,郑爱华,等.三七皂苷R1对过氧化氢诱导大鼠星形胶质细胞凋亡的影响[J].中华临床医师杂志(电子版),2013,6(15):7048-7053
[31] 黄金兰,秦嫦云,周楠,等.三七皂苷R1对D-半乳糖诱导痴呆模型小鼠学习记忆能力的影响及抗氧化应激作用研究[J].中国药房,2015,26(31):4336-4338
[32] Li Z,Li H,Zhao C,et al.Protective effect of notoginsenoside R1 on an APP/PS1 mouse model of alzheimer's disease by up-regulating insulin degrading enzyme and inhibiting Aβ accumulation[J].CNS Neurol Disord Drug Targets, 2015,14(3):360-369
[33] Yan S,Li Z,Li H,et al. Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation[J].Sci Rep, 2014,4:6352
[34] Ma B, Meng X, Wang J ,et al.Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation[J].Int Immunopharmacol,2014,22(1):151-159
[35] Meng X,Sun G,Ye J,et al.Notoginsenoside R1-mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: a novel mechanism of Nrf2/ARE signaling activation[J].Free Radic Res,2014,48(4):445-460
[36] Li XT, Ma W, Wang XB,et al.Notoginsenoside R1 promotes the growth of neonatal rat cortical neurons via the Wnt/β-catenin signaling pathway[J].CNS Neurol Disord Drug Targets,2018,17(7):547-556
[37] 赖小华,雷燕,杨静,等.基于microRNA-34a /SIRT1 /p53 通路探讨三七皂苷R1对血管内皮细胞衰老的影响[J].中国中药杂志,2018,43(3):577-584
[2] Yang Y, Xi P, Xie Y, et al.Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457[J].Int J Clin Exp Pathol, 2015,8(3):2700-2709
[3] Wang Y, Ren Y, Xing L, et al.Endothelium-dependent vasodilation effects of Panax notoginseng and its main components are mediated by nitric oxide and cyclooxygenase pathways[J].Exp Ther Med,2016,12(6):3998-4006
[4] 郭钰琪,齐冬梅,郝钰,等.三七皂苷R1调节炎性T细胞亚群保护血管内皮的实验研究[J].中国药理学通报,2012,28(2):240-244
[5] Jia C,Xiong M,Wang P,et al.Notoginsenoside R1 attenuates atherosclerotic lesions in ApoE deficient mouse model[J].PLoS One,2014,9(6): e99849
[6] Li LM, Liu RX, Guo JW, et al.In vivo pharmacokinetics of notoginsenoside R1 in ischemia rats after acute myocardial infarction[J].Zhong Yao Cai,2015,38(9):1908-1911
[7] 邓海英,赖为国.三七皂苷R1对急性心肌缺血大鼠模型的保护作用[J].中国实验方剂学杂志,2013,19(10):265-268
[8] 于俊民,鞠礼,王慧冬,等.三七皂苷R1对大鼠缺血心肌VEGF、bFGF 的影响[J].现代生物医学进展,2015,14(30):5845-5848
[9] Yang BR, Hong SJ, Lee SM,et al.Pro-angiogenic activity of notoginsenoside R1 in human umbilical vein endothelial cells in vitro and in a chemical-induced blood vessel loss model of zebrafish in vivo[J].Chin J Integr Med,2016,22(6):420-429
[10] He K,Yan L,Pan CS,et al.ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion -induced myocardial injury[J].Am J Physiol Heart Circ Physiol,2014,307(12):H1764-H1776
[11] Xia KP, Ca HM, Shao CZ.Protective effect of notoginsenoside R1 in a rat model of myocardial ischemia reperfusion injury by regulation of Vitamin D3 upregulated protein 1/NF-κB pathway[J].Pharmazie,2015,70(11):740-744
[12] Yu Y, Sun G, Luo Y,et al.Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways[J].Sci Rep,2016,6: 21730
[13] Ge ZR, Xu MC, Huang YU,et al.Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF-β1/TAK1 signaling pathway[J].Exp Ther Med,2016,11(6):2341-2348
[14] 万强,潘芸芸,贾钰华,等.三七皂苷R1抑制JNK通路减轻H2O2诱导心肌细胞损伤的作用[J].时珍国医国药,2015,26(9):2061-2064
[15] 周凤华,潘芸芸,贾钰华,等.Pim-2减轻H2 O2诱导乳鼠心肌细胞损伤及三七皂苷R1的干预研究[J].辽宁中医杂志,2017,44(3):618-622
[16] 周凤华,潘芸芸,崔小冰,等.ERK1/2与p38信号通路介导三七皂苷R1抗H2O2致心肌细胞损伤作用[J].中药药理与临床,2016,32(2):17-20
[17] Fang H,Yang S,Luo Y,et al.Notoginsenoside R1 inhibits vascular smooth muscle cell proliferation, migration and neointimal hyperplasia through PI3K/Akt signaling[J].Sci Rep,2018,8(1):7595
[18] Sun B, Xiao J, Sun XB, et al. Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling[J].Br J Pharmacol,2013,168(7):1758-1770
[19] Zhong L,Zhou XL,Liu YS,et al.Estrogen receptor α mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes[J].Mol Med Rep,2015,12(1): 119-126
[20] Xiao J,Zhu T,Yin YZ,et al.Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE-/- mice[J].Eur J Pharmacol,2018,833:441-450
[21] Wang Y,Tu L,Li Y,et al.Notoginsenoside R1 protects against neonatal cerebral hypoxic-ischemic injury through estrogen receptor-dependent activation of endoplasmic reticulum stress pathways[J].J Pharmacol Exp Ther,2016,357(3):591-605
[22] Wang Y,Tu L,Li Y,et al.Notoginsenoside R1 alleviates oxygen-glucose deprivation/reoxygenation injury by suppressing endoplasmic reticulum calcium release via PLC[J].Sci Rep,2017,7(1):16226
[23] Tu L,Wang Y,Chen D,et al.Protective effects of notoginsenoside R1 via regulation of the PI3K-Akt-mTOR/JNK pathway in neonatal cerebral hypoxic-ischemic brain injury[J].Neurochem Res,2018,43(6):1210-1226
[24] 侯倩伶,王岩,李英博,等.三七皂苷R1通过雌激素受体调节ATF6/Akt信号通路减轻OGD/R所导致的神经元损伤[J].中国中药杂志,2017,42(6):1167-1174
[25] Zhai Y, Meng X,Luo Y,et al.Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation[J].Oncotarget,2018,9(10):9344-9363
[26] 董晓华,张成龙,吴志刚,等.三七皂苷R1对大鼠脑缺血再灌注损伤的保护作用[J].中国老年学杂志,2015,35(7):1940-1942
[27] 赵志新,胡小铭,汪杰,等.三七皂苷R1对大鼠脑缺血-再灌注损伤后TNF-αmRNA 的影响[J].浙江创伤外科,2017,22(1):13-16
[28] Meng X,Wang M,Wang X,et al.Suppression of NADPH oxidaseand mitochondrion-derived superoxide by notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt /Nrf2 pathways[J].Free Radic Res,2014,48(7): 823-838
[29] Zou S,Zhang M,Feng L,et al.Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats[J].Exp Ther Med,2017,14(6):6012-6016
[30] 张鑫,林永文,郑爱华,等.三七皂苷R1对过氧化氢诱导大鼠星形胶质细胞凋亡的影响[J].中华临床医师杂志(电子版),2013,6(15):7048-7053
[31] 黄金兰,秦嫦云,周楠,等.三七皂苷R1对D-半乳糖诱导痴呆模型小鼠学习记忆能力的影响及抗氧化应激作用研究[J].中国药房,2015,26(31):4336-4338
[32] Li Z,Li H,Zhao C,et al.Protective effect of notoginsenoside R1 on an APP/PS1 mouse model of alzheimer's disease by up-regulating insulin degrading enzyme and inhibiting Aβ accumulation[J].CNS Neurol Disord Drug Targets, 2015,14(3):360-369
[33] Yan S,Li Z,Li H,et al. Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation[J].Sci Rep, 2014,4:6352
[34] Ma B, Meng X, Wang J ,et al.Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation[J].Int Immunopharmacol,2014,22(1):151-159
[35] Meng X,Sun G,Ye J,et al.Notoginsenoside R1-mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: a novel mechanism of Nrf2/ARE signaling activation[J].Free Radic Res,2014,48(4):445-460
[36] Li XT, Ma W, Wang XB,et al.Notoginsenoside R1 promotes the growth of neonatal rat cortical neurons via the Wnt/β-catenin signaling pathway[J].CNS Neurol Disord Drug Targets,2018,17(7):547-556
[37] 赖小华,雷燕,杨静,等.基于microRNA-34a /SIRT1 /p53 通路探讨三七皂苷R1对血管内皮细胞衰老的影响[J].中国中药杂志,2018,43(3):577-584