牛黄上清丸治疗寻常型痤疮及对IL-17、IL-18、TNF-α影响
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摘要
目的:探讨牛黄上清丸治疗寻常型痤疮及其对IL-17、IL-18及TNF-α的影响。方法:选择收治的寻常型痤疮患者102例,依据随机数字表法随机分为对照组和治疗组,各51例,对照组予以西医常规治疗;治疗组予以牛黄上清丸治疗,两组患者均治疗6周。比较两组患者临床疗效,血清IL-17、IL-18及TNF-α水平,中医证候积分改善情况。结果:治疗后,治疗组临床总有效率为90.20%,对照组临床总有效率为70.59%,治疗组较对照组改善明显,两组结果具有显著差异(P<0.05);两组患者血清IL-17、IL-18及TNF-α水平均有所降低,治疗组较对照组降低明显,结果具有显著差异(P<0.05);两组患者中医证候积分均有所改善,治疗组患者中医证候积分改善程度均较对照组显著(P<0.05)。结论:牛黄上清丸可有效治疗寻常型痤疮,改善其临床症状,促进病损部位皮肤新陈代谢速度,实验研究也表明痤疮的治疗应从多层面全方位的选择合理治疗方案,以增强疗效、减少不良反应为主要目的,故该方案值得临床推广应用。
Objective:To explore the effect of Niuhuang Shangqing Pill on serum IL-17,IL-18 and TNF-αin acne vulgaris. Methods:Collected our hospital 102 patients with acne vulgaris were randomly divided into treatment group and control group,51 for each. The control group was treated by Western medicine routine treatment,based on the control group,the treatment group was treated with Niuhuang Shangqing Pill,both of them would continue for 6 weeks. Compared the total clinical effective rate,the IL-17,IL-18 and TNF-αlevel in serum,the improvement of the TCM syndrome integral. Results:After the treatment,the total clinical effective rate was 90.20% in the treatment group,the total clinical effective rate was 70.59% in the control group,which was better than that in the control group,the difference was statistically significant(P<0.05);The improvement of serum IL-17,IL-18 and TNF-α in the treatment group was significantly higher than those in the control group(P<0.05);The improvement of TCM syndrome integral in the treatment group was significantly higher than that in the control group(P<0.05).Conclusion:Niuhuang Shangqing Pill could effectively treat acne vulgaris,improved the clinical symptoms and promoted the skin metabolism speed of the lesion. The experimental study also showed that the treatment of acne should be rational treatment plan from multiple levels,in order to enhance curative effect and reduce adverse reactions,so it was worthy of clinical application.
Objective:To explore the effect of Niuhuang Shangqing Pill on serum IL-17,IL-18 and TNF-αin acne vulgaris. Methods:Collected our hospital 102 patients with acne vulgaris were randomly divided into treatment group and control group,51 for each. The control group was treated by Western medicine routine treatment,based on the control group,the treatment group was treated with Niuhuang Shangqing Pill,both of them would continue for 6 weeks. Compared the total clinical effective rate,the IL-17,IL-18 and TNF-αlevel in serum,the improvement of the TCM syndrome integral. Results:After the treatment,the total clinical effective rate was 90.20% in the treatment group,the total clinical effective rate was 70.59% in the control group,which was better than that in the control group,the difference was statistically significant(P<0.05);The improvement of serum IL-17,IL-18 and TNF-α in the treatment group was significantly higher than those in the control group(P<0.05);The improvement of TCM syndrome integral in the treatment group was significantly higher than that in the control group(P<0.05).Conclusion:Niuhuang Shangqing Pill could effectively treat acne vulgaris,improved the clinical symptoms and promoted the skin metabolism speed of the lesion. The experimental study also showed that the treatment of acne should be rational treatment plan from multiple levels,in order to enhance curative effect and reduce adverse reactions,so it was worthy of clinical application.
引文
[1]李菲.温经燥湿汤联合火针治疗寻常性痤疮(寒湿症)的临床观察[D].哈尔滨:黑龙江中医药大学,2017.
[2]焦烨.玫瑰痤疮的临床特点及中医辨证分型研究[D].南京:南京中医药大学,2017.
[3]薛丹.寻常痤疮患者中医证型与发病季节、毛囊虫感染关系的探讨[D].北京:北京中医药大学,2017.
[4]于潮.中西医结合治疗对中重度痤疮患者外周血炎症因子IL-17、IL-18、IFN-γ的影响[D].大连:大连医科大学,2017.
[5]林锡娴.仙方活命饮治疗痤疮的meta分析及临床疗效观察[D].广州:广州中医药大学,2017.
[6]范宇焜.中国痤疮患者痤疮丙酸杆菌抗生素耐药性及基因型的多中心临床研究[D].重庆:第三军医大学,2016.
[7]中国痤疮治疗指南专家组.中国痤疮治疗指南(2014修订版)[J].临床皮肤科杂志,2015,44(1):52-58.
[8]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:292-294.
[9]皮佩瑶.饮食不节与寻常痤疮治疗的相关性文献研究[D].北京:北京中医药大学,2016.
[10]刘巧.菊翘解毒中药面膜治疗中度寻常痤疮的临床疗效和安全性观察[D].北京:北京中医药大学,2017.
[11]薛丹.寻常痤疮患者中医证型与发病季节、毛囊虫感染关系的探讨[D].北京:北京中医药大学,2017.
[12]丁大鹏,石云.寻常型痤疮与中医体质类型关系探讨[J].河北中医,2014,36(8):1135-1137.
[13]常晓丹,戴珊,叶珍珍,等.中西药结合治疗面部寻常型痤疮的临床观察[J].中国中西医结合杂志,2017,37(2):160-164.
[14]张琴.火针联合痤疮消炎片治疗寻常型痤疮的临床研究[D].广州:广州中医药大学,2017.
[15]温淑婷,肖莹.近10年寻常型痤疮文献的中医用药规律分析[J].中华中医药杂志,2016,31(9):3795-3798.
[16]瞿璐,王涛,董勇喆,等.菊花化学成分与药理作用的研究进展[J].药物评价研究,2015,38(1):98-104.
[17]钟昆芮.薄荷化学成分及其茎叶差异性研究[D].北京:北京中医药大学,2016.
[18]于潮.中西医结合治疗对中重度痤疮患者外周血炎症因子IL-17、IL-18、IFN-γ的影响[D].大连:大连医科大学,2017.
[19]施高翔,邵菁,汪天明,等.黄芩及其有效成分抗菌作用新进展[J].中国中药杂志,2014,39(19):3713-3718.
[20]王凤霞.石膏的药性功效及临床应用文献整理研究[D].北京:北京中医药大学,2015.
[2]焦烨.玫瑰痤疮的临床特点及中医辨证分型研究[D].南京:南京中医药大学,2017.
[3]薛丹.寻常痤疮患者中医证型与发病季节、毛囊虫感染关系的探讨[D].北京:北京中医药大学,2017.
[4]于潮.中西医结合治疗对中重度痤疮患者外周血炎症因子IL-17、IL-18、IFN-γ的影响[D].大连:大连医科大学,2017.
[5]林锡娴.仙方活命饮治疗痤疮的meta分析及临床疗效观察[D].广州:广州中医药大学,2017.
[6]范宇焜.中国痤疮患者痤疮丙酸杆菌抗生素耐药性及基因型的多中心临床研究[D].重庆:第三军医大学,2016.
[7]中国痤疮治疗指南专家组.中国痤疮治疗指南(2014修订版)[J].临床皮肤科杂志,2015,44(1):52-58.
[8]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:292-294.
[9]皮佩瑶.饮食不节与寻常痤疮治疗的相关性文献研究[D].北京:北京中医药大学,2016.
[10]刘巧.菊翘解毒中药面膜治疗中度寻常痤疮的临床疗效和安全性观察[D].北京:北京中医药大学,2017.
[11]薛丹.寻常痤疮患者中医证型与发病季节、毛囊虫感染关系的探讨[D].北京:北京中医药大学,2017.
[12]丁大鹏,石云.寻常型痤疮与中医体质类型关系探讨[J].河北中医,2014,36(8):1135-1137.
[13]常晓丹,戴珊,叶珍珍,等.中西药结合治疗面部寻常型痤疮的临床观察[J].中国中西医结合杂志,2017,37(2):160-164.
[14]张琴.火针联合痤疮消炎片治疗寻常型痤疮的临床研究[D].广州:广州中医药大学,2017.
[15]温淑婷,肖莹.近10年寻常型痤疮文献的中医用药规律分析[J].中华中医药杂志,2016,31(9):3795-3798.
[16]瞿璐,王涛,董勇喆,等.菊花化学成分与药理作用的研究进展[J].药物评价研究,2015,38(1):98-104.
[17]钟昆芮.薄荷化学成分及其茎叶差异性研究[D].北京:北京中医药大学,2016.
[18]于潮.中西医结合治疗对中重度痤疮患者外周血炎症因子IL-17、IL-18、IFN-γ的影响[D].大连:大连医科大学,2017.
[19]施高翔,邵菁,汪天明,等.黄芩及其有效成分抗菌作用新进展[J].中国中药杂志,2014,39(19):3713-3718.
[20]王凤霞.石膏的药性功效及临床应用文献整理研究[D].北京:北京中医药大学,2015.