胃癌组织中P53、IL-1β、NF-κB的表达及与幽门螺杆菌感染的相关性分析
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摘要
[目的]探讨胃癌组织中p53、IL-1β、NF-κB的表达及与幽门螺杆菌(Hp)感染的关系。[方法]选取2016年2月～2018年5月收治的97例胃癌患者为研究对象,根据Hp检查结果分组,Hp阳性组81例,Hp阴性组16例,另选97例体检健康者为对照组,对所有受检者胃癌组织中的p53、IL-1β、NF-κB表达情况进行观察。[结果]胃癌组患者的p53、IL-1β、NF-κB表达量均明显较对照组高,差异有统计学意义(P<0.05);Hp阳性组患者的p53、IL-1β、NF-κB表达量明显高于Hp阴性组患者,差异有统计学意义(P<0.05);Hp感染密度3级患者的p53、IL-1β、NF-κB表达量明显高于2级、1级患者,差异有统计学意义(P<0.05);经Perason相关性分析显示,p53、IL-1β、NF-κB表达量与胃癌患者的Hp感染呈正相关性(r分别为0.586、0.638、0.612,P<0.05)。[结论]胃癌组织中的p53、IL-1β、NF-κB表达量与Hp感染呈正相关性。
[Objective]To probe into the expression of p53, IL-1 beta and NF-kappa B in gastric cancer and its relationship with Helicobacter pylori(Hp) infection. [Methods]97 cases of patients with gastric cancer treated from February, 2016 to May, 2018 were selected. Patients were divided into 2 groups, including Hp-positive group and Hp-negative group. 81 cases were positive for Hp and 16 cases were negative for Hp. Another 97 cases of healthy persons who underwent the physical examination were selected as control group. Then, the expression of p53, IL-1β and NF-kappa B in gastric cancer of all subjects were observed. [Results]The expression levels of p53, IL-1β and NF-kappa B in gastric cancer group were significantly higher than that in control group(P<0.05).The expression levels of p53, IL-1β and NF-kappa B in the positive group were significantly higher than those in the negative group(P<0.05).The expression levels of p53, IL-1β and NF-kappa B in patients with grade 3 of Hp infection density were significantly higher than those in patients with grade 1 and 2(P<0.05). Perason correlation analysis showed that the expression of p53, IL-1β and NF-kappa B was positively correlated with Hp infection in gastric cancer patients(r was 0.586, 0.638 and 0.612, respectively, P<0.05). [Conclusion]The expression levels of p53, IL-1 beta and NF-kappa B in gastric cancer tissues are positively correlated with Hp infection.
[Objective]To probe into the expression of p53, IL-1 beta and NF-kappa B in gastric cancer and its relationship with Helicobacter pylori(Hp) infection. [Methods]97 cases of patients with gastric cancer treated from February, 2016 to May, 2018 were selected. Patients were divided into 2 groups, including Hp-positive group and Hp-negative group. 81 cases were positive for Hp and 16 cases were negative for Hp. Another 97 cases of healthy persons who underwent the physical examination were selected as control group. Then, the expression of p53, IL-1β and NF-kappa B in gastric cancer of all subjects were observed. [Results]The expression levels of p53, IL-1β and NF-kappa B in gastric cancer group were significantly higher than that in control group(P<0.05).The expression levels of p53, IL-1β and NF-kappa B in the positive group were significantly higher than those in the negative group(P<0.05).The expression levels of p53, IL-1β and NF-kappa B in patients with grade 3 of Hp infection density were significantly higher than those in patients with grade 1 and 2(P<0.05). Perason correlation analysis showed that the expression of p53, IL-1β and NF-kappa B was positively correlated with Hp infection in gastric cancer patients(r was 0.586, 0.638 and 0.612, respectively, P<0.05). [Conclusion]The expression levels of p53, IL-1 beta and NF-kappa B in gastric cancer tissues are positively correlated with Hp infection.
引文
[1] 路敏敏,刘京运,金世禄,等.胃癌及癌前病变黏膜组织中环氧化酶-2、p53的表达及其与幽门螺杆菌感染的相关性[J].川北医学院学报,2016,31(3):410-412.
[2] 程智勇,杨雁鸿,李桃,等.Tip30和p53蛋白在胃癌组织中的表达及其临床意义[J].疑难病杂志,2016,15(8):813-816.
[3] 中华人民共和国国家卫生和计划生育委员会.胃癌规范化诊疗指南(试行)[J].慢性病学杂志,2013,5(10):47-51.
[4] Wei LM,Cao S,Yu WD,et al.Overexpression of CX3 CR1 is associated with cellular metastasis,proliferation and survival in gastric cancer[J].Oncol Rep,2015,33(2):615-24.
[5] 牟海军,陈小燕,化伟利,等.胃癌患者幽门螺杆菌的感染与预后的关系[J].中华医院感染学杂志,2016,26(16):3643-3644,3647.
[6] Cho YS,Chung IK,Kim JH,et al.Risk factors of developing interval early gastric cancer after negative endoscopy[J].Digest Dis Sci,2015,60(4):936-43.
[7] 尚颖,赵立元,陆景坤,等.炎性细胞因子与胃癌的关系[J].中国药科大学学报,2015,46(1):123-128.
[8] 帕提玛·阿布力米提,节阳华,谢新梅,等.幽门螺杆菌感染与胃癌发生及预后的相关性研究[J].成都医学院学报,2016,11(5):546-549.
[9] 陈晓兵.胃癌患者幽门螺杆菌感染情况与肿瘤恶性程度的相关性研究[J].海南医学院学报,2017,23(4):475-477,481.
[10] 陈俊利,温莹,常虹,等.IL-1 B和IL-1 RN基因多态性与非贲门胃癌发病风险的研究[J].现代预防医学,2016,43(2):342-345.
[11] 高永庆,邓玉林,徐长青,等.IL-1β、IL-6、p53与胃癌组织幽门螺杆菌感染的相关性分析[J].标记免疫分析与临床,2018,25(5):665-668.
[12] 李彦,马欢,李媛,等.NF-κB与IL-8在幽门螺杆菌相关性胃癌组织中的表达及意义[J].实用医学杂志,2016,32(4):583-585.
[13] 赵煜,曾杰银.NF-κB在胃癌组织中的表达与临床病理的相关性研究[J].中国医药导报,2015,12(29):70-73.
[14] 沈书旭.幽门螺杆菌通过NF-κB信号通路调控胃上皮细胞自噬及凋亡的机制研究[J].安徽医药,2018,22(6):1058-1063.
[2] 程智勇,杨雁鸿,李桃,等.Tip30和p53蛋白在胃癌组织中的表达及其临床意义[J].疑难病杂志,2016,15(8):813-816.
[3] 中华人民共和国国家卫生和计划生育委员会.胃癌规范化诊疗指南(试行)[J].慢性病学杂志,2013,5(10):47-51.
[4] Wei LM,Cao S,Yu WD,et al.Overexpression of CX3 CR1 is associated with cellular metastasis,proliferation and survival in gastric cancer[J].Oncol Rep,2015,33(2):615-24.
[5] 牟海军,陈小燕,化伟利,等.胃癌患者幽门螺杆菌的感染与预后的关系[J].中华医院感染学杂志,2016,26(16):3643-3644,3647.
[6] Cho YS,Chung IK,Kim JH,et al.Risk factors of developing interval early gastric cancer after negative endoscopy[J].Digest Dis Sci,2015,60(4):936-43.
[7] 尚颖,赵立元,陆景坤,等.炎性细胞因子与胃癌的关系[J].中国药科大学学报,2015,46(1):123-128.
[8] 帕提玛·阿布力米提,节阳华,谢新梅,等.幽门螺杆菌感染与胃癌发生及预后的相关性研究[J].成都医学院学报,2016,11(5):546-549.
[9] 陈晓兵.胃癌患者幽门螺杆菌感染情况与肿瘤恶性程度的相关性研究[J].海南医学院学报,2017,23(4):475-477,481.
[10] 陈俊利,温莹,常虹,等.IL-1 B和IL-1 RN基因多态性与非贲门胃癌发病风险的研究[J].现代预防医学,2016,43(2):342-345.
[11] 高永庆,邓玉林,徐长青,等.IL-1β、IL-6、p53与胃癌组织幽门螺杆菌感染的相关性分析[J].标记免疫分析与临床,2018,25(5):665-668.
[12] 李彦,马欢,李媛,等.NF-κB与IL-8在幽门螺杆菌相关性胃癌组织中的表达及意义[J].实用医学杂志,2016,32(4):583-585.
[13] 赵煜,曾杰银.NF-κB在胃癌组织中的表达与临床病理的相关性研究[J].中国医药导报,2015,12(29):70-73.
[14] 沈书旭.幽门螺杆菌通过NF-κB信号通路调控胃上皮细胞自噬及凋亡的机制研究[J].安徽医药,2018,22(6):1058-1063.