乳腺非特殊类型浸润性癌磁共振增强特点与预后因子的相关性探讨
摘要
目的探讨磁共振乳腺非特殊类型浸润性癌动态增强表现与预后因子ER、PR、HER2、细胞核增殖抗原Ki-67、抑癌基因p53、上皮生长因子EGFR、细胞角蛋白CK5/6、术区淋巴结的相关性。方法分析80例乳腺非特殊类型浸润性癌患者的术前动态增强MR探讨特点与预后因子的相关性。结果乳腺非特殊类型浸润性癌形态不规则与Ki-67阳性表达存在正相关;环形强化与术区淋巴结阳性表达存在正相关;动态增强时间-信号强度曲线的Ⅲ型曲线与CK5/6阳性表达存在正相关;病灶中心层面最大长径2-5cm组病例与Ki-67、p53、术区淋巴结的阳性表达存在正相关。结论乳腺非特殊类型浸润性癌的动态增强特点与部分预后因子有显著相关性,磁共振动态增强检查是临床选择治疗方案的重要参考。
引文
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[6]Chen JH,Baek HM,Nalcioglu O,et al.Estrogen receptor and breast MR imaging features:a correlation study[J].Magn Reson Imaging,2008,27(4):825-833.
[7]Chagpar AB,Camp RL,Rimm DL,et al.Lymph node ratio should be considered for incorporation into staging for breast cancer[J].Ann Surg Oncol,2011,18(11):3134-3148.
[8]邓再兴,俞文菊,朱凯.乳腺癌组织CK5/6与EGFR表达及其临床意义的研究[J].中华肿瘤防治杂志,2008,15(19):1477-1480.
[9]王黎明.乳腺浸润性导管癌3T磁共振动态增强特征与预后的相关性研究[J].中国医学影像学杂志,2011,19(8):596-600.
[10]Verma S,Provencher L,Dent R,et al.Emerging trends in the treatment of triple-negative breast cancer in Canada:a survey[J].Curr Oncol,2011,18(4):180-190.
[11]Kumar S,Walia V,Ray M,et al.p53 in breast cancer:mutation and countermeasures[J].Front Bio Sci,2007,12:4168-4178.
[12]Nalwoga H,Arnes JB,Wabinga H,et al.Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women[J].APMIS,2008,116(6):515-525.
[13]万宇,黄建军,包刚,等.三阴性乳腺癌的临床病理特征和EGFR、Ki67的表达及相关性[J].江西医药,2016,51(4):291-293,300.
[14]Cai H,Kong W,Zhou T,et al.Radiofrequency ablation versus resection in treating recurrent hepatocellular carcinoma:a metaanalysis[J].Medicine(Baltimore),2014,93(22):el22.
[15]Chawki S,Ploussard G,Montlahuc C,et al.Bladder cancer in HIV-infected adults:an emerging concern?[J].J Int AIDS Soc,2014,17(4Suppl3):19647.
[16]王盈盈,常晓丹,付娇慧,等.乳腺浸润性导管癌3.0T MRI表现与预后因子相关性研究[J].磁共振成像,2014,5(2):132-137.