布地奈德与地塞米松对急性喉炎患儿炎症反应及免疫功能的影响
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摘要
目的:分别探讨布地奈德与地塞米松对急性喉炎患儿炎症反应及免疫功能的改善效果。方法:回顾性分析2015年6月—2018年5月我院收治的116例急性喉炎患儿的临床资料,依据临床用药方案的不同分为两组,各58例。对照组采用地塞米松(0.25～0.5 mg/kg,qd)治疗,观察组采用布地奈德(2 mL,tid)治疗,比较两组炎症因子[C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-(tumor necrosis factor,TNF)-α、白细胞介素(interleukin,IL)]-6水平、免疫功能及症状消失时间。结果:治疗3 d后,观察组CRP、TNF-α、IL-6水平均低于对照组,差异有统计学意义(P <0.05);治疗前后两组CD3+、CD4~+、CD8~+值比较,差异无统计学意义(P> 0.05);观察组哮鸣音、犬吠样咳嗽、声嘶以及呼吸困难消失时间均短于对照组,差异有统计学意义(P <0.05)。结论:与地塞米松比较,布地奈德雾化吸入治疗小儿急性喉炎,可有效缓解炎症反应,缩短临床症状消失时间,且不会对免疫功能产生明显影响。
Objective: To investigate the improving effect of budesonide and dexamethasone on in?ammatory response and immune function in children with acute laryngitis. Methods: The clinical data of 116 children with acute laryngitis admitted to our hospital from June 2015 to May 2018 were retrospectively analyzed, and the children were divided into two groups according to the different clinical drug use schemes, 58 cases each. The children in the control group were treated with dexamethasone(0.25 ～ 0.5 mg/kg, qd), while the children in the observation group were treated with budesonide(2 mL, tid). The levels of inflammatory factors [C-reactive protein(CRP),tumor necrosis factor(TNF)-α, interleukin(IL)-6], immune function and disappearance time of symptoms were compared between the two groups. Results: After 3 days of treatment, the levels of CRP, TNF-α and IL-6 in the observation group were lower than those in the control group, with statistically signi?cant differences(P<0.05).There were no statistically signi?cant differences in the values of CD3+, CD4~+ and CD8~+ before and after treatment(P>0.05). The disappearance time of wheezing, barking cough, hoarseness and dyspnea in the observation group was shorter than that in the control group, with statistically signi?cant differences(P<0.05). Conclusion: Compared with dexamethasone, budesonide aerosol inhalation can effectively alleviate in?ammation response and shorten the disappearance time of clinical symptoms in the treatment of acute laryngitis in children, and has no signi?cant effect on immune function.
Objective: To investigate the improving effect of budesonide and dexamethasone on in?ammatory response and immune function in children with acute laryngitis. Methods: The clinical data of 116 children with acute laryngitis admitted to our hospital from June 2015 to May 2018 were retrospectively analyzed, and the children were divided into two groups according to the different clinical drug use schemes, 58 cases each. The children in the control group were treated with dexamethasone(0.25 ～ 0.5 mg/kg, qd), while the children in the observation group were treated with budesonide(2 mL, tid). The levels of inflammatory factors [C-reactive protein(CRP),tumor necrosis factor(TNF)-α, interleukin(IL)-6], immune function and disappearance time of symptoms were compared between the two groups. Results: After 3 days of treatment, the levels of CRP, TNF-α and IL-6 in the observation group were lower than those in the control group, with statistically signi?cant differences(P<0.05).There were no statistically signi?cant differences in the values of CD3+, CD4~+ and CD8~+ before and after treatment(P>0.05). The disappearance time of wheezing, barking cough, hoarseness and dyspnea in the observation group was shorter than that in the control group, with statistically signi?cant differences(P<0.05). Conclusion: Compared with dexamethasone, budesonide aerosol inhalation can effectively alleviate in?ammation response and shorten the disappearance time of clinical symptoms in the treatment of acute laryngitis in children, and has no signi?cant effect on immune function.
引文
[1]包旭武,皮贵荣,禹教化,等.布地奈德联合利多卡因治疗小儿急性喉炎的疗效及安全性评价[J].中国病案,2018,19(12):104-107.
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[6]赵继民.肾上腺素与布地奈德交替雾化吸入治疗小儿急性喉炎合并喉梗阻的疗效分析[J].中国合理用药探索,2018,15(11):130-132,136.
[7]高治平.不同激素治疗小儿急性喉炎并呼吸困难的随机对照研究[J].西南国防医药,2017,27(11):1181-1183.
[8]李辉,潘玲.肾上腺素与布地奈德交替雾化吸入治疗小儿急性喉炎合并喉梗阻的疗效和护理干预[J].检验医学与临床,2017,14(14):2128-2129.
[2]康泽刚.异丙托溴铵联合布地奈德混悬液雾化吸入治疗上呼吸道感染后慢性咳嗽的疗效及对免疫功能的影响[J].中国合理用药探索,2017,14(11):70-72,80.
[3]刘林凤,李维军.麻杏石甘汤联合布地奈德雾化吸入对小儿急性喉炎疗效及免疫功能的影响[J].中国中医急症,2018,27(11):1940-1942.
[4]卢燕,谭利平.布地奈德雾化吸入治疗小儿急性喉炎的临床疗效观察[J].中国妇幼保健,2016,31(19):3978-3979.
[5]陈秋萍,周瑞芳,张亚明,等.全身激素联合吸入激素治疗急性喉炎疗效观察[J].中华耳鼻咽喉头颈外科杂志,2018,53(01):53-56.
[6]赵继民.肾上腺素与布地奈德交替雾化吸入治疗小儿急性喉炎合并喉梗阻的疗效分析[J].中国合理用药探索,2018,15(11):130-132,136.
[7]高治平.不同激素治疗小儿急性喉炎并呼吸困难的随机对照研究[J].西南国防医药,2017,27(11):1181-1183.
[8]李辉,潘玲.肾上腺素与布地奈德交替雾化吸入治疗小儿急性喉炎合并喉梗阻的疗效和护理干预[J].检验医学与临床,2017,14(14):2128-2129.