丹参多酚酸盐静脉注射治疗ACI疗效及对患者脑血流动力学、氧化应激指标的影响
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摘要
目的观察丹参多酚酸盐静脉注射治疗急性脑梗死(AcuteCerebralInfarction,ACI)患者临床疗效及对患者脑血流动力学、氧化应激指标的影响。方法选取我院收治的108例急性脑梗死患者作为研究对象,随机分为观察组和对照组各54例。对照组给予常规治疗方法;观察组在对照组的基础上联用丹参多酚酸盐静脉注射均治疗2周。比较两组治疗后脑血流动力学以[大脑前动脉(Anteriorcerebralartery,ACA),大脑中动脉(Middlecerebralartery,MCA)以及大脑后动脉(Posteriorcerebralartery,PCA)]及氧化应激各项指标[氧化低密度脂蛋白(Oxidizedlowdensitylipoprotein,OX-LDL)、丙二醛(Malondialdehyde,MDA)]变化,并观察治疗结束后临床疗效[神经功能缺损程度评分(National Institute of Health stroke scale,NIHSS)减分率]。结果治疗后,观察组ACA、MCA、PCA较对照组降低明显(P<0.05);氧化应激指标OX-LDL、MDA浓度比对照组有显著降低(P<0.05)。治疗后,观察组NIHSS量表评分总有效率为88.89%,高于对照组患者治疗后总有效率64.82%。结论丹参多酚酸盐静脉注射治疗急性脑梗塞临床疗效显著,可以有效改善患者脑血流动力学和氧化应激状态。
Objective To observe the clinical efficacy of intravenous injection of salvianolate in the treatment of patients with acute cerebral infarction(ACI) and its effects on cerebral hemodynamics and oxidative stress indexes. Methods108 patients with acute cerebral infarction admitted to our hospital were selected as subjects and were randomly divided into observation group and control group, with 54 cases in each group. Control group was given conventional treatment, and observation group was given intravenous injection of salvianolate on the basis of control group,and they were treated for 2 w. The cerebral hemodynamics [anterior cerebral artery(ACA), middle cerebral artery(MCA) and posterior cerebral artery(PCA)] and oxidative stress indexes [oxidized low density lipoprotein(OX-LDL),malondialdehyde(MDA)] were compared between the two groups after treatment. And the clinical efficacy [National Institute of Health Stroke Scale(NIHSS) reduction rate] was observed after the end of treatment. Results After treatment, the ACA, MCA and PCA in observation group were significantly lower than those in control group(P<0.05).The oxidative stress indexes OX-LDL and MDA were significantly lower than those in control group(P<0.05). After treatment, the total effective rate of NIHSS scale score in observation group was higher than that in control group(88.89% vs 64.82%). Conclusion Intravenous injection of salvianolate has significant clinical efficacy in the treatment of acute cerebral infarction, and it can effectively improve the cerebral hemodynamics and oxidative stress status.
Objective To observe the clinical efficacy of intravenous injection of salvianolate in the treatment of patients with acute cerebral infarction(ACI) and its effects on cerebral hemodynamics and oxidative stress indexes. Methods108 patients with acute cerebral infarction admitted to our hospital were selected as subjects and were randomly divided into observation group and control group, with 54 cases in each group. Control group was given conventional treatment, and observation group was given intravenous injection of salvianolate on the basis of control group,and they were treated for 2 w. The cerebral hemodynamics [anterior cerebral artery(ACA), middle cerebral artery(MCA) and posterior cerebral artery(PCA)] and oxidative stress indexes [oxidized low density lipoprotein(OX-LDL),malondialdehyde(MDA)] were compared between the two groups after treatment. And the clinical efficacy [National Institute of Health Stroke Scale(NIHSS) reduction rate] was observed after the end of treatment. Results After treatment, the ACA, MCA and PCA in observation group were significantly lower than those in control group(P<0.05).The oxidative stress indexes OX-LDL and MDA were significantly lower than those in control group(P<0.05). After treatment, the total effective rate of NIHSS scale score in observation group was higher than that in control group(88.89% vs 64.82%). Conclusion Intravenous injection of salvianolate has significant clinical efficacy in the treatment of acute cerebral infarction, and it can effectively improve the cerebral hemodynamics and oxidative stress status.
引文
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[8]卢志刚,黄家彬,刘芸,等.醒脑静注射液对急性脑梗死Keap1-Nrf2/ARE氧化应激通路的影响[J].广东医学,2016,37(20):3127-3129.
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[10]袁凤云,刘玉梅,孙科远,等.丹参多酚酸盐对脑梗死患者脑血流动力学的影响分析[J].中国煤炭工业医学杂志,2015,18(6):895-898.
[2]全国第四届脑血管病学术会议通过.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):376-381
[3]刁瑞青,刘春梅.探讨分析丹参多酚酸盐对脑梗塞患者脑血流动力学的影响[J].大医生,2017,2(6):87-88.
[4]苏宗权,王顺旺.注射用丹参多酚酸盐治疗急性脑梗死的临床疗效观察[J].吉林医学,2017,38(8):1545-1547.
[5]王珲,王琴,戚妹,等.丹参多酚酸盐对脑梗塞患者脑血流动力学的影响[J].海南医学,2015,26(6):794-796.
[6]常慧敏,李常新.注射用丹参多酚酸治疗急性脑梗死的研究进展[J].中西医结合心脑血管病杂志,2018,16(2):183-185.
[7]方保锋,牛晓光.阿托伐他汀对急性脑梗死患者氧化应激指标及颈动脉斑块的影响[J].中国社区医师,2016,32(35):29-30.
[8]卢志刚,黄家彬,刘芸,等.醒脑静注射液对急性脑梗死Keap1-Nrf2/ARE氧化应激通路的影响[J].广东医学,2016,37(20):3127-3129.
[9]王红权,赵姝丽.丹参多酚酸盐治疗脑梗死对脑血流动力学及神经功能与日常生活能力的影响[J].中国实用神经疾病杂志,2016,19(14):64-66.
[10]袁凤云,刘玉梅,孙科远,等.丹参多酚酸盐对脑梗死患者脑血流动力学的影响分析[J].中国煤炭工业医学杂志,2015,18(6):895-898.