姜黄素对A549裸鼠移植瘤影响的网状Meta分析
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摘要
目的:采用网状Meta分析评价姜黄素对A549裸鼠移植瘤的影响。方法:系统检索主要中文数据库,纳入数据库中有关姜黄素对A549裸鼠移植瘤影响的动物实验,采用SYRCLE动物实验风险评估工具评价纳入研究质量,STATA13.0软件对数据进行合并分析。结果:共纳入7个研究,网状Meta分析结果显示,与空白相比姜黄素能够减轻瘤重,缩小肿瘤体积,降低肿瘤微血管密度,在姜黄素基础上,加用顺铂可以增加疗效。结论:姜黄素对A549肺癌细胞裸鼠移植瘤的生长具有明显抑制作用。
Objective: To assess the effect of curcumin on human lung adenocarcinoma A549 xenografted tumor in nude mice. Methods: We searched major Chinese database. The animal studies of curcumin on human lung adenocarcinoma A549 xenografted tumor in nude mice were including,the quality of including studies were assessed by SYRCLE' s risk of bias tool,and the related data were analyzed by STATA13. 0 software. Results: 7 studies were included,the network Meta-analysis showed that,compared with the no treatment,curcumin could reduce the mean volume and weight of the xenografted tumor,and decrease microvessel density,at the same time,curcumin combined with cisplatin could increase the effect. Conclusion: The current evidence showed that curcumin could significantly effects on human lung adenocarcinoma A549 xenografted tumor in nude mice.
Objective: To assess the effect of curcumin on human lung adenocarcinoma A549 xenografted tumor in nude mice. Methods: We searched major Chinese database. The animal studies of curcumin on human lung adenocarcinoma A549 xenografted tumor in nude mice were including,the quality of including studies were assessed by SYRCLE' s risk of bias tool,and the related data were analyzed by STATA13. 0 software. Results: 7 studies were included,the network Meta-analysis showed that,compared with the no treatment,curcumin could reduce the mean volume and weight of the xenografted tumor,and decrease microvessel density,at the same time,curcumin combined with cisplatin could increase the effect. Conclusion: The current evidence showed that curcumin could significantly effects on human lung adenocarcinoma A549 xenografted tumor in nude mice.
引文
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[7]田金徽,李伦,赵晔,等.网状Meta分析的撰写与报告[J].中国药物评价,2013,30(6):321-323,333.
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[11]唐春兰,杨和平,李剑明,等.姜黄素Ⅲ对A549裸鼠移植瘤VEGF蛋白表达的影响[J].第三军医大学学报,2005,27(9):831-833.
[12]唐春兰,杨和平,李剑明,等.姜黄素Ⅲ对体内肺腺癌移植瘤裸鼠血管生成的影响[J].中国临床康复,2005,9(22):163-165.
[13]唐春兰,杨和平,李剑明,等.姜黄素Ⅲ和顺铂联用抑制A549裸小鼠移植瘤生长作用研究[J].第三军医大学学报,2005,27(11):1071-1073.
[14]唐春兰,杨和平,李剑明,等.姜黄素Ⅲ抑制A549裸小鼠移植瘤生长及其血管生成的实验研究[J].第三军医大学学报,2004,26(21):1950-1953.
[15]杨和平,宫亮,唐春兰,等.双脱甲氧基姜黄素对肺腺癌细胞A549生长活性影响的初步研究[J].重庆医学,2005,34(6):868-870.
[16]李小江,贾英杰,张文治,等.姜黄素对A549细胞亚群SP和NON-SP的NF-κB、VEGF及Notch通路的影响[J].天津中医药,2016,33(3):164-168.
[17]吴胤瑛,李恩孝.VEGF在恶性肿瘤中的研究进展[J].现代肿瘤医学,2005,13(5):附18-附21.
[18]龙明智,陈磊磊.313姜黄素的药理作用[J].国外医学(中医中药分册),2003,25(5):270-272,287.
[19]Lin CC,Lu YP,Lou YR,et al.Inhibition by dietary dibenzoylmethane of mammary gland proliferation,formation of DMBA-DNA adducts in mammary glands,and mammary tumorigenesis in Sencar mice[J].Cancer Letters,2001,168(2):125-132.
[20]Troglio G,Alberti M,Benediksson JA,et al.Curcumin(diferuloylmethane)induces apoptosis through activation of caspase-8,BID cleavage and cytochrome c release:its suppression by ectopic expression of Bcl-2 and Bcl-xl[J].Carcinogenesis,2002,23(1):143-150.
[2]Ramsewak R S,De Witt D L,Nair M G,et al.Cytotoxicity,antioxidant and anti-inflammatory activities of curcuminsⅠ-Ⅲfrom Curcuma longa[J].Phytomedicine International Journal of Phytotherapy&Phytopharmacology,2000,7(4):303-308.
[3]李剑明,杨和平,刘松青.三种姜黄色素单体抑制人内皮细胞作用的实验研究[J].重庆医学,2002,31(9):804-805.
[4]Aggarwal BB,Kumar A,Bharti AC.Anticancer potential of curcumin:preclinical and clinical studies[J].Anticancer Research,2003,23(1A):363-398.
[5]Gururaj AE,Belakavadi M,Venkatesh DA,et al.Molecular mechanisms of anti-angiogenic effect of curcumin[J].Biochemical&Biophysical Research Communications,2002,297(4):934-942.
[6]田金徽,陈耀龙,杨克虎,等.SR/MA研究进展与挑战[J].兰州大学学报(医学版),2016,42(1):42-47.
[7]田金徽,李伦,赵晔,等.网状Meta分析的撰写与报告[J].中国药物评价,2013,30(6):321-323,333.
[8]田金徽.中药注射剂联合化疗治疗非小细胞肺癌的网状Meta分析[D].兰州大学,2012.
[9]Hooijmans CR,Rovers MM,Vries RBD,et al.SYRCLE's risk of bias tool for animal studies[J].Bmc Medical Research Methodology,2014,14(1):43.
[10]杨和平,李剑明,唐春兰,等.姜黄色素活性单体成分抗血管生成的实验研究[J].第三军医大学学报,2005,27(11):1068-1070.
[11]唐春兰,杨和平,李剑明,等.姜黄素Ⅲ对A549裸鼠移植瘤VEGF蛋白表达的影响[J].第三军医大学学报,2005,27(9):831-833.
[12]唐春兰,杨和平,李剑明,等.姜黄素Ⅲ对体内肺腺癌移植瘤裸鼠血管生成的影响[J].中国临床康复,2005,9(22):163-165.
[13]唐春兰,杨和平,李剑明,等.姜黄素Ⅲ和顺铂联用抑制A549裸小鼠移植瘤生长作用研究[J].第三军医大学学报,2005,27(11):1071-1073.
[14]唐春兰,杨和平,李剑明,等.姜黄素Ⅲ抑制A549裸小鼠移植瘤生长及其血管生成的实验研究[J].第三军医大学学报,2004,26(21):1950-1953.
[15]杨和平,宫亮,唐春兰,等.双脱甲氧基姜黄素对肺腺癌细胞A549生长活性影响的初步研究[J].重庆医学,2005,34(6):868-870.
[16]李小江,贾英杰,张文治,等.姜黄素对A549细胞亚群SP和NON-SP的NF-κB、VEGF及Notch通路的影响[J].天津中医药,2016,33(3):164-168.
[17]吴胤瑛,李恩孝.VEGF在恶性肿瘤中的研究进展[J].现代肿瘤医学,2005,13(5):附18-附21.
[18]龙明智,陈磊磊.313姜黄素的药理作用[J].国外医学(中医中药分册),2003,25(5):270-272,287.
[19]Lin CC,Lu YP,Lou YR,et al.Inhibition by dietary dibenzoylmethane of mammary gland proliferation,formation of DMBA-DNA adducts in mammary glands,and mammary tumorigenesis in Sencar mice[J].Cancer Letters,2001,168(2):125-132.
[20]Troglio G,Alberti M,Benediksson JA,et al.Curcumin(diferuloylmethane)induces apoptosis through activation of caspase-8,BID cleavage and cytochrome c release:its suppression by ectopic expression of Bcl-2 and Bcl-xl[J].Carcinogenesis,2002,23(1):143-150.