宁波地区52140例患者四项传染病感染特征分析
|
摘要
目的了解宁波地区四项传染病患者特征及重叠感染情况。方法以2015年11月-2018年3月宁波某医院共52 140例患者为研究对象,采用ELISA法检测HBsAg、抗TP、抗HCV及抗HIV,将患者按性别、年龄、户籍进行分组,分别统计各组阳性率,并对重叠感染情况进行分析。结果四项指标总阳性率分别为HBsAg(9.41%)、抗TP(3.17%)、抗HCV(0.30%)、抗HIV(0.09%),其中男性患者各项阳性率均明显高于女性(P<0.05);HBV及TP感染率随着年龄增长先上升然后下降,HIV感染趋于低龄化;宁波籍男性抗TP阳性率较高,非宁波籍男性HBsAg、抗HCV及抗HIV阳性率较高(P<0.01);有186例为重叠感染,其中HBV合并TP感染141例,占比最多。结论宁波地区四项传染病以男性群体阳性率较高,尤以中青年为主,同时伴未成年患者增加,宁波籍与非宁波籍患者感染特征不同,中青年男性是防治重点人群;重叠感染较为严重,以HBV合并TP最多。
Objective To investigate the characteristics and mixed infection of patients with 4 infectious diseases in Ningbo. Methods A total of 52 140 cases were selected from a hospital for the study from November 2015 to March 2018. HBsAg, Anti-TP, Anti-HCV) and Anti-HIV were detected by ELISA. The patients were divided into groups according to gender, age and household registration. The positive rate of each group was counted and the overlapping infections were analyzed. Results The positive rate of 4 test programs were respectively HBsAg(9.41%), Anti-TP(3.17%), Anti-HCV(0.30%) and Anti-HIV(0.09%), and the positive rates in males were statistically higher than that in females(P<0.05). The positive rates of HBsAg, Anti-TP and Anti-HIV were different among age groups(P<0.05), the infectious rate of TP and HBV gradually increased and then reduced with the growth of age, and HIV infected cases show a lower trend of age. Males with household registered in Ningbo had a higher rate of Anti-TP, on the contrary, a higher rate of HBsAg, HCV and HIV was in males without household registered in Ningbo. And the differences were statistically significant(P<0.01). Mixed infection were found in 186 cases, of which 141 cases were with HBV and TP co-infection, accounting for the highest. Conclu-sion The positive rate of 4 infectious diseases were high in males, predominantly the middle-aged in Ningbo area. The number of minors increased, the infectious characteristics was different between cases with or without household registered in Ningbo, the prevention and control should be focused on the mid-aged males. Mixed infection was serious and most cases were HBV and TP co-infection.
Objective To investigate the characteristics and mixed infection of patients with 4 infectious diseases in Ningbo. Methods A total of 52 140 cases were selected from a hospital for the study from November 2015 to March 2018. HBsAg, Anti-TP, Anti-HCV) and Anti-HIV were detected by ELISA. The patients were divided into groups according to gender, age and household registration. The positive rate of each group was counted and the overlapping infections were analyzed. Results The positive rate of 4 test programs were respectively HBsAg(9.41%), Anti-TP(3.17%), Anti-HCV(0.30%) and Anti-HIV(0.09%), and the positive rates in males were statistically higher than that in females(P<0.05). The positive rates of HBsAg, Anti-TP and Anti-HIV were different among age groups(P<0.05), the infectious rate of TP and HBV gradually increased and then reduced with the growth of age, and HIV infected cases show a lower trend of age. Males with household registered in Ningbo had a higher rate of Anti-TP, on the contrary, a higher rate of HBsAg, HCV and HIV was in males without household registered in Ningbo. And the differences were statistically significant(P<0.01). Mixed infection were found in 186 cases, of which 141 cases were with HBV and TP co-infection, accounting for the highest. Conclu-sion The positive rate of 4 infectious diseases were high in males, predominantly the middle-aged in Ningbo area. The number of minors increased, the infectious characteristics was different between cases with or without household registered in Ningbo, the prevention and control should be focused on the mid-aged males. Mixed infection was serious and most cases were HBV and TP co-infection.
引文
[1] WHO.Guidelines for the prevention,care and treatment of per-sons with chronic hepatitis B infection[S].Geneva:World Heath Orgnization,2015.
[2] 宋雪东.输血前患者4项感染指标检测结果与流行趋势[J].国际检验医学杂志,2016,37(2):272-274.
[3] 郭小慧.输血前及手术前四项感染指标的检测及临床意义[J].中国感染控制杂志,2017,16(6):561-563.
[4] 胡海亮,杨鹏,卞茂红,等.输血前4项感染性指标的结果分析及其临床意义[J].临床血液学杂志:输血与检验,2015,28(2):303-306.
[5] 闫文强,刘久波,范金波,等.手术前和输血前血液传播性疾病感染因子检测及意义[J].临床血液学杂志,2012,23(2):93-95.
[6] 沈云良,费丽娟,吴李梅,等.浙江省2004-2014年梅毒流行趋势分析[J].中国公共卫生,2016,32(1):35-37.
[7] 石磊,张燕蕾,赵枫,等.宁波某医院2005-2013年梅毒感染者流行病学分析[J].中国公共卫生,2015,31(10):1350-1352.
[8] 严华美,杨瑛,张星灿,等.上海市闵行区2005-2016年梅毒疫情分析[J].复旦学报,2017,44(5):585-589.
[9] 任红.丙型肝炎防治,任重道远[J].中华肝脏病杂志,2013,21(6):401-402.
[10] 李志勤,武淑环,余祖江,等.387例丙型肝炎患者流行病学及临床特征研究[J].中华医院感染学杂志,2011,21(11):2255-2257.
[11] 陈国生,李黎,崔富强,等.中国丙型肝炎血清流行病学研究[J].中华流行病学杂志,2011,32(9):888-891.
[12] 高巧珍,任淑珍.19586例术前四项检测结果的讨论[J].医学信息杂志,2015,28(42):14-15.
[13] 穆银玉,卢娜清,章琳,等.2011年-2015年宁波地区人类免疫缺陷病毒感染状况分析[J].中国卫生检验杂志,2016,26(16):2361-2363.
[14] 张继红,李怀亮,史宏博,等.宁波市2004年-2015年抗病毒治疗HIV/AIDS患者生存分析[J].中华流行病学杂志,2016,37(9):1262-1267.
[15] 袁麒翔,李加林,徐谅慧,等.宁波市外来流动人口特征及其变化趋势-基于第5、第6次全国人口普查资料的分析[J].宁波大学学报,2014,27(2):121-124.
[16] 吴琼,曾月嫦,李一鸣,等.输血前检测传染性指标对降低患者医院感染的意义[J].中国卫生标准管理,2016,7(7):192-194.
[2] 宋雪东.输血前患者4项感染指标检测结果与流行趋势[J].国际检验医学杂志,2016,37(2):272-274.
[3] 郭小慧.输血前及手术前四项感染指标的检测及临床意义[J].中国感染控制杂志,2017,16(6):561-563.
[4] 胡海亮,杨鹏,卞茂红,等.输血前4项感染性指标的结果分析及其临床意义[J].临床血液学杂志:输血与检验,2015,28(2):303-306.
[5] 闫文强,刘久波,范金波,等.手术前和输血前血液传播性疾病感染因子检测及意义[J].临床血液学杂志,2012,23(2):93-95.
[6] 沈云良,费丽娟,吴李梅,等.浙江省2004-2014年梅毒流行趋势分析[J].中国公共卫生,2016,32(1):35-37.
[7] 石磊,张燕蕾,赵枫,等.宁波某医院2005-2013年梅毒感染者流行病学分析[J].中国公共卫生,2015,31(10):1350-1352.
[8] 严华美,杨瑛,张星灿,等.上海市闵行区2005-2016年梅毒疫情分析[J].复旦学报,2017,44(5):585-589.
[9] 任红.丙型肝炎防治,任重道远[J].中华肝脏病杂志,2013,21(6):401-402.
[10] 李志勤,武淑环,余祖江,等.387例丙型肝炎患者流行病学及临床特征研究[J].中华医院感染学杂志,2011,21(11):2255-2257.
[11] 陈国生,李黎,崔富强,等.中国丙型肝炎血清流行病学研究[J].中华流行病学杂志,2011,32(9):888-891.
[12] 高巧珍,任淑珍.19586例术前四项检测结果的讨论[J].医学信息杂志,2015,28(42):14-15.
[13] 穆银玉,卢娜清,章琳,等.2011年-2015年宁波地区人类免疫缺陷病毒感染状况分析[J].中国卫生检验杂志,2016,26(16):2361-2363.
[14] 张继红,李怀亮,史宏博,等.宁波市2004年-2015年抗病毒治疗HIV/AIDS患者生存分析[J].中华流行病学杂志,2016,37(9):1262-1267.
[15] 袁麒翔,李加林,徐谅慧,等.宁波市外来流动人口特征及其变化趋势-基于第5、第6次全国人口普查资料的分析[J].宁波大学学报,2014,27(2):121-124.
[16] 吴琼,曾月嫦,李一鸣,等.输血前检测传染性指标对降低患者医院感染的意义[J].中国卫生标准管理,2016,7(7):192-194.