萝卜硫素的研究进展
|
摘要
萝卜硫素是一种植物活性物质,服用一定剂量能对动物和人体产生多种有益的生理作用。由于它表现出来的功能,对它的研究也在逐年增加。最近的研究表明它对糖尿病的治疗有潜在的积极的作用。对萝卜硫素展开系统地研究和了解可以为开发新药物提供理论基础,为人们健康的生活方式提供指导意见,具有广阔的应用前景。为了对萝卜硫素的研究进展有一个较全面的认识,我们决定收集并整理相关资料进行综述的撰写,也为人们开发萝卜硫素的应用提供有价值的参考。本文综合萝卜硫素研究领域近年来多方面的研究结果,主要对其生理功能、药理机制做出简明综述。
Sulforaphane is a kind of plant active substance, taking a certain dose can produce a variety of beneficial physiological effects on animals and humans. Because of its functions, research on it is also increasing year by year. Recent studies have shown that it has potentially positive effects on the treatment of diabetes. Systematic research and understanding of sulforaphane can provide theoretical basis for the development of new drugs, provide guidance for people's healthy lifestyle and have broad application prospects. In order to have a comprehensive understanding of the research progress of the sulforaphane, we decided to collect and sort out the relevant information to summarize the writing, but also provide valuable reference for people to develop the application value of the sulforaphane. In this paper, we summarize some aspects of research on sulforaphane in recent years and make a brief review of its physiological functions and pharmacological mechanisms.
Sulforaphane is a kind of plant active substance, taking a certain dose can produce a variety of beneficial physiological effects on animals and humans. Because of its functions, research on it is also increasing year by year. Recent studies have shown that it has potentially positive effects on the treatment of diabetes. Systematic research and understanding of sulforaphane can provide theoretical basis for the development of new drugs, provide guidance for people's healthy lifestyle and have broad application prospects. In order to have a comprehensive understanding of the research progress of the sulforaphane, we decided to collect and sort out the relevant information to summarize the writing, but also provide valuable reference for people to develop the application value of the sulforaphane. In this paper, we summarize some aspects of research on sulforaphane in recent years and make a brief review of its physiological functions and pharmacological mechanisms.
引文
[1]高灿红,林俊城,徐福乐,郑金贵.15个西兰花芽苗中萝卜硫素含量差异研究[J].中国农学通报,2012.
[2]谢述琼,何珺,何军.9种十字花科蔬菜食用部位中萝卜硫素含量研究[J].安徽农业大学学报,2013.
[3]顾晓娟,张亮,邹宇,陈志刚,韩永斌,顾振新.高效液相色谱法测定西兰花中萝卜硫素的研究[J].食品工业科技,2012.
[4]阳晖,杨呈凤,李昌满,王慧超,何秀利,周琴,王精林,吴成军.胭脂萝卜废渣中萝卜硫素的提取工艺研究[J].食品科技,2016,41(2):259-264.
[5]Zhang Y,Talalay P,Cho CG,Posner GH,A major inducer of anticarcinogenic protective enzymes from broccoli:isolation and elucidation of structure[J],Proc Natl Acad Sci USA,1992,89(6):2399-403.
[6]罗真真,张震,乔亚敏,陈新峰,黄岚,张毅.萝卜硫素对结直肠癌SW620细胞增殖、凋亡及迁移的影响[J].郑州大学学报(医学版),2017.
[7]毛卫林,田锦成,吴品,刘艳.萝卜硫素下调Traf6/NF-k B信号通路抑制肾癌细胞增殖的作用研究[J].广东药科大学学报,2017.
[8]贺云冲,贾侃,王川,沈雯,洪姣,黄春琦,任军,许健.西兰花提取物萝卜硫素抑制胃癌和胰腺癌的生长与侵袭[J].科技通报,2015.
[9]马林伟,徐红涛、赵聪俐,张清.萝卜硫素对A375黑色素瘤增殖、生长、凋亡和血管生成的影响及其机制[J].沈阳药科大学学报,2017.
[10]Mokhtari RB,Baluch N,Homayouni TS,Morgatskaya E,Kumar S,Kazemi P,Yeger H.Erratum to:The role of Sulforaphane in cancer chemoprevention and health benefits:a mini-review[J].J Cell Commun Signal,2017,doi:10.1007/s12079-017-0408-4.
[11]Kwak MK,Wakabayashi N,Kensler TW,Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers[J].Mutat Res,2004,555(1-2):133-148.
[12]王永刚.萝卜硫素通过上调Nrf2的表达和功能减少糖尿病小鼠睾丸细胞凋亡的研究[D].吉林大学,2015.
[13]孔丽丽.萝卜硫素在小鼠糖尿病肾病中的肾脏保护机制研究[D].吉林大学,2015.
[14]任翔.硫氧还蛋白对糖尿病视网膜神经细胞损伤的保护作用及相关机制研究[D].大连医科大学,2017.
[15]扶玉珍.萝卜硫素对2型糖尿病小鼠耳蜗毛细胞退行性变的保护作用及机制研究[D].大连医科大学,2015.
[16]Zhang Z.;Zhou S.;Jiang X.;Wang Y.H.;Li F.;Wang Y.G.;Zheng Y.;Cai L.The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome[J].Rev Endocr Metab Disord.2015,16,35-45.
[17]Axelsson AS,Tubbs E,Mecham B,Chacko S,Nenonen HA,Tang Y,Fahey JW,Derry JMJ,Wollheim CB,Wierup N,Haymond MW,Friend SH,Mulder H.Rosengren AH.Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes[J].Sci Transl Med.2017,9(394)doi:10.1126/scitranslmed.aah4477
[18]Johansson NL,Pavia CS,Chiao JW.Growth Inhibition of a Spectrum of Bacterial and Fungal Pathogens by Sulforaphane,an Isothiocyanate Product Found in Broccoli and Other Cruciferous Vegetables[J].Planta Med.2008,74(7):747-750.
[19]梁洪华.萝卜硫素对缺氧肺动脉平滑肌细胞增殖和迁移影响的研究[D].广西医科大学,2017.
[20]王丽萍.萝卜硫素对分化型甲状腺癌细胞NIS基因表达及摄碘能力的影响[J].陕西医学杂志,2015.
[2]谢述琼,何珺,何军.9种十字花科蔬菜食用部位中萝卜硫素含量研究[J].安徽农业大学学报,2013.
[3]顾晓娟,张亮,邹宇,陈志刚,韩永斌,顾振新.高效液相色谱法测定西兰花中萝卜硫素的研究[J].食品工业科技,2012.
[4]阳晖,杨呈凤,李昌满,王慧超,何秀利,周琴,王精林,吴成军.胭脂萝卜废渣中萝卜硫素的提取工艺研究[J].食品科技,2016,41(2):259-264.
[5]Zhang Y,Talalay P,Cho CG,Posner GH,A major inducer of anticarcinogenic protective enzymes from broccoli:isolation and elucidation of structure[J],Proc Natl Acad Sci USA,1992,89(6):2399-403.
[6]罗真真,张震,乔亚敏,陈新峰,黄岚,张毅.萝卜硫素对结直肠癌SW620细胞增殖、凋亡及迁移的影响[J].郑州大学学报(医学版),2017.
[7]毛卫林,田锦成,吴品,刘艳.萝卜硫素下调Traf6/NF-k B信号通路抑制肾癌细胞增殖的作用研究[J].广东药科大学学报,2017.
[8]贺云冲,贾侃,王川,沈雯,洪姣,黄春琦,任军,许健.西兰花提取物萝卜硫素抑制胃癌和胰腺癌的生长与侵袭[J].科技通报,2015.
[9]马林伟,徐红涛、赵聪俐,张清.萝卜硫素对A375黑色素瘤增殖、生长、凋亡和血管生成的影响及其机制[J].沈阳药科大学学报,2017.
[10]Mokhtari RB,Baluch N,Homayouni TS,Morgatskaya E,Kumar S,Kazemi P,Yeger H.Erratum to:The role of Sulforaphane in cancer chemoprevention and health benefits:a mini-review[J].J Cell Commun Signal,2017,doi:10.1007/s12079-017-0408-4.
[11]Kwak MK,Wakabayashi N,Kensler TW,Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers[J].Mutat Res,2004,555(1-2):133-148.
[12]王永刚.萝卜硫素通过上调Nrf2的表达和功能减少糖尿病小鼠睾丸细胞凋亡的研究[D].吉林大学,2015.
[13]孔丽丽.萝卜硫素在小鼠糖尿病肾病中的肾脏保护机制研究[D].吉林大学,2015.
[14]任翔.硫氧还蛋白对糖尿病视网膜神经细胞损伤的保护作用及相关机制研究[D].大连医科大学,2017.
[15]扶玉珍.萝卜硫素对2型糖尿病小鼠耳蜗毛细胞退行性变的保护作用及机制研究[D].大连医科大学,2015.
[16]Zhang Z.;Zhou S.;Jiang X.;Wang Y.H.;Li F.;Wang Y.G.;Zheng Y.;Cai L.The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome[J].Rev Endocr Metab Disord.2015,16,35-45.
[17]Axelsson AS,Tubbs E,Mecham B,Chacko S,Nenonen HA,Tang Y,Fahey JW,Derry JMJ,Wollheim CB,Wierup N,Haymond MW,Friend SH,Mulder H.Rosengren AH.Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes[J].Sci Transl Med.2017,9(394)doi:10.1126/scitranslmed.aah4477
[18]Johansson NL,Pavia CS,Chiao JW.Growth Inhibition of a Spectrum of Bacterial and Fungal Pathogens by Sulforaphane,an Isothiocyanate Product Found in Broccoli and Other Cruciferous Vegetables[J].Planta Med.2008,74(7):747-750.
[19]梁洪华.萝卜硫素对缺氧肺动脉平滑肌细胞增殖和迁移影响的研究[D].广西医科大学,2017.
[20]王丽萍.萝卜硫素对分化型甲状腺癌细胞NIS基因表达及摄碘能力的影响[J].陕西医学杂志,2015.