脑动脉硬化症患者血清中同型半胱氨酸的表达
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摘要
目的探讨脑动脉硬化症患者血清中同型半胱氨酸(Hcy)表达。方法选取2017年7月至2019年2月在合肥市第二人民医院确诊为脑动脉硬化症的患者50例作为研究组,并选取同时期在我院接受体检且确认为健康的50例体检者作为对照组,测定其血清Hcy浓度。结果对照组血清Hcy阳性5例,研究组血清Hcy阳性22例;对照组血清Hcy浓度(9.81±1.92)μmol/L低于研究组血清Hcy浓度(16.51±3.85)μmol/L,差异有统计学意义(P<0.05)。结论脑动脉硬化症患者中血清Hcy升高。
Objective To investigate the expression of homocysteine(Hcy) in serum of patients with cerebral arteriosclerosis. Method 50 patients with cerebral arteriosclerosis diagnosed in the Second People's Hospital of Hefei from July 2017 to February 2019 were selected as the study group, and 50 physical examinations who were confirmed to be healthy in our hospital at the same time were selected as the control group. The serum Hcy levels were measured.Result There were 5 cases of positive serum Hcy in the control group and 22 cases of positive serum Hcy in the study group. The concentration of serum Hcy in the control group(9.81±1.92) μmol/L was lower than that in the study group(16.51±3.85) μmol/L, and the difference was statistically significant(P<0.05). Conclusion The serum level of Hcy in patients with cerebral arteriosclerosis is elevated.
Objective To investigate the expression of homocysteine(Hcy) in serum of patients with cerebral arteriosclerosis. Method 50 patients with cerebral arteriosclerosis diagnosed in the Second People's Hospital of Hefei from July 2017 to February 2019 were selected as the study group, and 50 physical examinations who were confirmed to be healthy in our hospital at the same time were selected as the control group. The serum Hcy levels were measured.Result There were 5 cases of positive serum Hcy in the control group and 22 cases of positive serum Hcy in the study group. The concentration of serum Hcy in the control group(9.81±1.92) μmol/L was lower than that in the study group(16.51±3.85) μmol/L, and the difference was statistically significant(P<0.05). Conclusion The serum level of Hcy in patients with cerebral arteriosclerosis is elevated.
引文
[1]陈梅,罗莉芸,陈健珍,等.高血压和脑动脉硬化症与血清同型半胱氨酸浓度变化相关性分析[J].实验与检验医学,2016,34(3):371-373.
[2]罗春苗,高潮,冯俊.同型半胱氨酸及脑钠肽水平与慢性心力衰竭危险分级的相关性分析[J].中国循证心血管医学杂志,2016,8(3):280-282.
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[4]胡中文.脑动脉粥样硬化性狭窄与血清同型半胱氨酸水平和亚甲基四氢叶酸还原酶C677T基因多态性相关性研究[D].蚌埠医学院,2015:5-10.
[5]刘会星,牛广义,孔静波.帕金森病患者血清同型半胱氨酸、氧化应激与周围神经病变的相关性分析[J].脑与神经疾病杂志,2018,26(1):32-35.
[6]王蕾,陈哲萌,陈浩,等.高血压合并脑梗死患者同型半胱氨酸与颈动脉硬化相关性研究[J].中华全科医学,2015,13(8):1270-1272.
[7]刘虹,金娟,周志凤,等.慢性肾脏病患者甲状旁腺激素同型半胱氨酸检测的临床意义[J].河北医学,2019,25(3):577-580.
[8]张瑞.脑梗死患者血清同型半胱氨酸、血浆叶酸和维生素B12水平的相关性研究[J].现代检验医学杂志,2015,30(5):118-120.
[9]杨文娟,魏博平,修可鹏,等.同型半胱氨酸、维生素B12、叶酸浓度与脑梗死的相关性研究[J].检验医学与临床,2017,14(Z1):335-338.
[2]罗春苗,高潮,冯俊.同型半胱氨酸及脑钠肽水平与慢性心力衰竭危险分级的相关性分析[J].中国循证心血管医学杂志,2016,8(3):280-282.
[3]黄雯,曾小茹,莫发敏.308例老年高血压病患者动脉硬化检测结果分析[J].中国医学创新,2013,10(32):132-134.
[4]胡中文.脑动脉粥样硬化性狭窄与血清同型半胱氨酸水平和亚甲基四氢叶酸还原酶C677T基因多态性相关性研究[D].蚌埠医学院,2015:5-10.
[5]刘会星,牛广义,孔静波.帕金森病患者血清同型半胱氨酸、氧化应激与周围神经病变的相关性分析[J].脑与神经疾病杂志,2018,26(1):32-35.
[6]王蕾,陈哲萌,陈浩,等.高血压合并脑梗死患者同型半胱氨酸与颈动脉硬化相关性研究[J].中华全科医学,2015,13(8):1270-1272.
[7]刘虹,金娟,周志凤,等.慢性肾脏病患者甲状旁腺激素同型半胱氨酸检测的临床意义[J].河北医学,2019,25(3):577-580.
[8]张瑞.脑梗死患者血清同型半胱氨酸、血浆叶酸和维生素B12水平的相关性研究[J].现代检验医学杂志,2015,30(5):118-120.
[9]杨文娟,魏博平,修可鹏,等.同型半胱氨酸、维生素B12、叶酸浓度与脑梗死的相关性研究[J].检验医学与临床,2017,14(Z1):335-338.