静息态功能磁共振成像技术在失眠中的应用
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摘要
静息态功能磁共振成像(Resting State Functional Magnetic Resonance Imaging,rs-fMRI)是一项基于静息态功能网络研究的功能磁共振技术,通过磁共振功能成像来探索人类神经系统,比任务态fMRI更简单易行。本文将对rs-fMRI的成像原理、分析方法、特点及在失眠中的应用几个方面进行综述,以期为该项技术在失眠的研究中提供依据。
Resting state functional magnetic resonance imaging(fMRI)(resting state-functional magnetic resonance imaging,rs-fMRI)is a function of resting state network based study of functional magnetic resonance imaging(mri)technology.It is more simple than task fMRI.This article would analyze the rs-fMRI imaging principle,method and its application in insomnia and provide basis for the technology in the study of insomnia.
Resting state functional magnetic resonance imaging(fMRI)(resting state-functional magnetic resonance imaging,rs-fMRI)is a function of resting state network based study of functional magnetic resonance imaging(mri)technology.It is more simple than task fMRI.This article would analyze the rs-fMRI imaging principle,method and its application in insomnia and provide basis for the technology in the study of insomnia.
引文
[1]冯俊榜,王光昶,艾敏.血氧水平依赖性脑功能成像的研究进展[J].成都医学院学报,2013,8(4):489-491.
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[6]Biswal B,Yetkin FZ,Haughton VM,et al.Functional connectivity in the motor codex of resting human brain using echo-planar MRI[J].Magn Reson Med,1995,34(4):537-541.
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[8]Fox MD,Snyder AZ,Vincent JL,et al.The human brain isintrinsically organized into dynamic,anticorrelated functional networks[J].Proc Natl Acad Sci USA,2005,102(27):9673-9678.
[9]Lanius RA,Bluhm RL,Coupland NJ,et al.Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatizedsubjects[J].Acta Psychiatr Scand,2010,121(1):33-40.
[10]Liu CH,Liu CZ,Zhang J,et al.Reduced spontaneous neuronal activity in the insularcortex and thalamus in healthy adultswithinsomnia symptoms[J].Brain Res,2016,1648(A):317-324.
[11]朱雪玲,袁福来.基于区域的抑郁症默认网络内部功能连接研究[J].中国临床心理学杂志,2016,24(2):218-220,212.
[12]聂晓,戴西件,刘雪琴,等.原发性失眠默认网络亚区功能连接的功能磁共振成像研究[J].临床放射学杂志,2015,34(12):1880-1884.
[13]Greicius MD,Krasnow B,Reiss AL,et al.Functional connectivity in the resting brain:a network analysis of the default mode hypothesis[J].Proc Natl Acad Sci USA,2003,100(1):253-258.
[14]Mantini D,Perrucci MG,Del GC,et al.Electrophysiological signatures of resting statenetworks in the human brain[J].Proc Natl Acad Sci USA,2007,104(32):13170-13175.
[15]Zang YF,He Y,Zhu CZ,et al.Altered baseline brain activity in children with ADHDrevealed by restingstate functional MRI[J].Brain Dev,2007,29(2):83-91.
[16]Zang Y1,Jiang T,Lu Y,et al.Regional homogeneity approach to fMRI data analysis[J].Neuroimage,2004,22(1):394-400.
[17]熊燕兵,任燕,崔晓红,等.早发精神分裂症静息态脑功能低频振幅研究[J].中国神经精神疾病杂志,2016,42(5):272-276.
[18]梁敏杰,周全,杨晓玲,等.原发性失眠患者基于局部一致性的静息态脑功能改变研究[J].临床放射学杂志,2014,33(1):10-14.
[19]Smith SM1,Miller KL,Salimi-Khorshidi G,et al.Network modelling methods for FMRI[J].Neuroimage,2011,54(2):875-891.
[20]Hu S,Dai G,Worrell GA,et al.Causality analysis of neural connectivity:critical examin-ation of existing methods and advances of new methods[J].IEEE Trans Neural Netw,2011,22(6):829-844.
[21]Celone KA,Calhoun VD,Dickerson BC,et al.Alterations in memorynetworks in mild cognitive impairment and Alzheimer's disease:an independentcomponent analysis[J].The Journal of neuroscience,2006,26(40):10222-10231.
[22]Gardini S,Venneri A,Sambataro F,et al.Increased functional connectivity in the default mode network in mild cognitive impairment:a maladaptive compensatory mechanism associated with poor semantic memory performance[J].JAlzheimers diseaseJAD,2015,45(2):457-470.
[23]Hoshino M1,Tsujio T,Terai H,et al.Impact of initial conservative treatmentinterventions on the outcomes of patients with osteoporotic vertebral fractures[J].Spine(Phila Pa 1976),2013,38(11):641-648.
[24]赵莹.脊髓型颈椎病认知功能变化及其静息态功能连接的fMRI研究[D].天津:天津医科大学,2015.
[25]黄宏星.中国6城市普通人群失眠状况及京沪穗医师对抑郁伴失眠患者的认知及处理状况调查[J].中国医药导刊,2006,8(2):100.
[26]宋无名,陈南圭.功能MRI:最先进方法的简要回顾和展望[J].磁共振成像,2013,4(5):361-372.
[27]张红菊.原发性失眠患者脑功能连接的磁共振研究[D].河南,郑州大学,2014.
[28]李永丽,王恩锋,张红菊,等.原发性失眠患者默认网络神经功能的静息态MRI研究[J].中国医学影像学杂志,2014,22(7):481-486.
[29]Huang Z,Liang P,Jia X,et al.Abnormal amygdala connectivity inpatients with primary insomnia:evidence from resting state fMRI[J].European Journal of Radiology,2012,81(6):1288-1295.
[30]黄素华.原发性失眠的静息态脑功能磁共振成像研究[D].南昌:南昌大学医学院,2013.
[31]Dai XJ,Peng DC,Gong HH,et al.Altered intrinsic regional brainspontaneous activity and subjective sleep quality in patients with chronic primary insomnia:a resting-state fMRI study[J].Neuropsychiatric Disease and Treatment,2014,14(10):2163-2175.
[32]Dai XJ,Nie X,Liu X,et al.Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia:Evidence from a Resting-State fMRI Study[J].JClinSleepMed,2016,12(3):363-374.
[33]Li C,Ma X,Dong M,et al.Abnormal spontaneous regional brain activity in primary insomnia:a resting-state functional magnetic resonance imaging study[J].Neuropsychiatr Dis Treat,2016,14(12):1371-1378.
[34]赖明君.伴睡眠障碍的首发单相抑郁症患者静息态脑功能磁共振与睡眠结构的初步研究[D].广东,广州医科大学,2014.
[35]黄素华.原发性失眠的静息态脑功能磁共振成像研究[D].南昌:南昌大学,2013.
[36]魏歆,李传明,周振华,等.原发性失眠伴认知功能障碍患者静息态功能MRI的局部一致性研究[J].中华放射学杂志,2016,50(6):401-405.
[37]Li C,Dong M,Yin Y,et al.Abnormal whole-brain functional connectivity in patients with primary insomnia[J].Neuropsychiatric Dis Treat,2017,13(13):427-435.
[38]Li S,Tian J,Li M,et al.Altered resting state connectivity in right side frontoparietal network in primary insomnia patients[J].European Radiology,2017,8(21):1432-1084.
[39]Pang R,Zhan Y,Zhang Y,et al.Aberrant Functional Connectivity Architecture in Participants with Chronic Insomnia Disorder Accompanying Cognitive Dysfunction:A Whole-Brain,Data-Driven Analysis[J].Front Neurosci,2017,11(259):1-39.
[40]肖佐香,慢性原发性失眠的静息态功能磁共振成像研究[D].南昌:南昌大学,2016.
[2]Wong ET,Tishler R,Barron L,et al.Immunochemotherapy with rituximab and temozolomide for central nervous system lymphomas[J].Cancer,2004,101(1):139-145.
[3]吴宏赘,齐向华.功能磁共振在睡眠障碍中的应用进展[J].中国医药导报,2014,11(6):159-161,166.
[4]Ogawa S,Lee TM,Kay AR,et al.Brain magnetic resonanceimaging with contrast dependent on blood oxygenation[J].PNAS,1990,87(24):9868-9872.
[5]王一托,李功杰,乔鹏刚.BOLD-fMRI在脑卒中患者触觉功能康复过程中的应用现状[J].中国临床影像学杂志,2015,26(9):671-673.
[6]Biswal B,Yetkin FZ,Haughton VM,et al.Functional connectivity in the motor codex of resting human brain using echo-planar MRI[J].Magn Reson Med,1995,34(4):537-541.
[7]Liu Y,Wang K,Yu C,He Y,et al.Regional homogeneity,functional connectivity and imaging markers of Alzheimer's disease:a review of resting-state fMRI studies[J].Neuropsychologia,2008,46(6):1648-1656.
[8]Fox MD,Snyder AZ,Vincent JL,et al.The human brain isintrinsically organized into dynamic,anticorrelated functional networks[J].Proc Natl Acad Sci USA,2005,102(27):9673-9678.
[9]Lanius RA,Bluhm RL,Coupland NJ,et al.Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatizedsubjects[J].Acta Psychiatr Scand,2010,121(1):33-40.
[10]Liu CH,Liu CZ,Zhang J,et al.Reduced spontaneous neuronal activity in the insularcortex and thalamus in healthy adultswithinsomnia symptoms[J].Brain Res,2016,1648(A):317-324.
[11]朱雪玲,袁福来.基于区域的抑郁症默认网络内部功能连接研究[J].中国临床心理学杂志,2016,24(2):218-220,212.
[12]聂晓,戴西件,刘雪琴,等.原发性失眠默认网络亚区功能连接的功能磁共振成像研究[J].临床放射学杂志,2015,34(12):1880-1884.
[13]Greicius MD,Krasnow B,Reiss AL,et al.Functional connectivity in the resting brain:a network analysis of the default mode hypothesis[J].Proc Natl Acad Sci USA,2003,100(1):253-258.
[14]Mantini D,Perrucci MG,Del GC,et al.Electrophysiological signatures of resting statenetworks in the human brain[J].Proc Natl Acad Sci USA,2007,104(32):13170-13175.
[15]Zang YF,He Y,Zhu CZ,et al.Altered baseline brain activity in children with ADHDrevealed by restingstate functional MRI[J].Brain Dev,2007,29(2):83-91.
[16]Zang Y1,Jiang T,Lu Y,et al.Regional homogeneity approach to fMRI data analysis[J].Neuroimage,2004,22(1):394-400.
[17]熊燕兵,任燕,崔晓红,等.早发精神分裂症静息态脑功能低频振幅研究[J].中国神经精神疾病杂志,2016,42(5):272-276.
[18]梁敏杰,周全,杨晓玲,等.原发性失眠患者基于局部一致性的静息态脑功能改变研究[J].临床放射学杂志,2014,33(1):10-14.
[19]Smith SM1,Miller KL,Salimi-Khorshidi G,et al.Network modelling methods for FMRI[J].Neuroimage,2011,54(2):875-891.
[20]Hu S,Dai G,Worrell GA,et al.Causality analysis of neural connectivity:critical examin-ation of existing methods and advances of new methods[J].IEEE Trans Neural Netw,2011,22(6):829-844.
[21]Celone KA,Calhoun VD,Dickerson BC,et al.Alterations in memorynetworks in mild cognitive impairment and Alzheimer's disease:an independentcomponent analysis[J].The Journal of neuroscience,2006,26(40):10222-10231.
[22]Gardini S,Venneri A,Sambataro F,et al.Increased functional connectivity in the default mode network in mild cognitive impairment:a maladaptive compensatory mechanism associated with poor semantic memory performance[J].JAlzheimers diseaseJAD,2015,45(2):457-470.
[23]Hoshino M1,Tsujio T,Terai H,et al.Impact of initial conservative treatmentinterventions on the outcomes of patients with osteoporotic vertebral fractures[J].Spine(Phila Pa 1976),2013,38(11):641-648.
[24]赵莹.脊髓型颈椎病认知功能变化及其静息态功能连接的fMRI研究[D].天津:天津医科大学,2015.
[25]黄宏星.中国6城市普通人群失眠状况及京沪穗医师对抑郁伴失眠患者的认知及处理状况调查[J].中国医药导刊,2006,8(2):100.
[26]宋无名,陈南圭.功能MRI:最先进方法的简要回顾和展望[J].磁共振成像,2013,4(5):361-372.
[27]张红菊.原发性失眠患者脑功能连接的磁共振研究[D].河南,郑州大学,2014.
[28]李永丽,王恩锋,张红菊,等.原发性失眠患者默认网络神经功能的静息态MRI研究[J].中国医学影像学杂志,2014,22(7):481-486.
[29]Huang Z,Liang P,Jia X,et al.Abnormal amygdala connectivity inpatients with primary insomnia:evidence from resting state fMRI[J].European Journal of Radiology,2012,81(6):1288-1295.
[30]黄素华.原发性失眠的静息态脑功能磁共振成像研究[D].南昌:南昌大学医学院,2013.
[31]Dai XJ,Peng DC,Gong HH,et al.Altered intrinsic regional brainspontaneous activity and subjective sleep quality in patients with chronic primary insomnia:a resting-state fMRI study[J].Neuropsychiatric Disease and Treatment,2014,14(10):2163-2175.
[32]Dai XJ,Nie X,Liu X,et al.Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia:Evidence from a Resting-State fMRI Study[J].JClinSleepMed,2016,12(3):363-374.
[33]Li C,Ma X,Dong M,et al.Abnormal spontaneous regional brain activity in primary insomnia:a resting-state functional magnetic resonance imaging study[J].Neuropsychiatr Dis Treat,2016,14(12):1371-1378.
[34]赖明君.伴睡眠障碍的首发单相抑郁症患者静息态脑功能磁共振与睡眠结构的初步研究[D].广东,广州医科大学,2014.
[35]黄素华.原发性失眠的静息态脑功能磁共振成像研究[D].南昌:南昌大学,2013.
[36]魏歆,李传明,周振华,等.原发性失眠伴认知功能障碍患者静息态功能MRI的局部一致性研究[J].中华放射学杂志,2016,50(6):401-405.
[37]Li C,Dong M,Yin Y,et al.Abnormal whole-brain functional connectivity in patients with primary insomnia[J].Neuropsychiatric Dis Treat,2017,13(13):427-435.
[38]Li S,Tian J,Li M,et al.Altered resting state connectivity in right side frontoparietal network in primary insomnia patients[J].European Radiology,2017,8(21):1432-1084.
[39]Pang R,Zhan Y,Zhang Y,et al.Aberrant Functional Connectivity Architecture in Participants with Chronic Insomnia Disorder Accompanying Cognitive Dysfunction:A Whole-Brain,Data-Driven Analysis[J].Front Neurosci,2017,11(259):1-39.
[40]肖佐香,慢性原发性失眠的静息态功能磁共振成像研究[D].南昌:南昌大学,2016.