从痰和郁论治乳腺多发结节260例
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摘要
目的观察从痰、郁论治乳腺多发结节的临床疗效及安全性。方法将260例乳腺多发结节患者,按随机数值表法分为治疗组138例和对照组122例。治疗组给予口服化痰散结、疏肝解郁的汤剂,对照组给予口服小金胶囊,观察2组患者服药后的临床疗效、结节大小变化、疼痛变化、性激素水平变化、月经、情志、失眠变化及不良反应等。结果治疗组的临床痊愈率、总有效率均明显高于对照组(P<0.05);与治疗前比较,治疗后2组的结节大小评分、疼痛变化评分、雌二醇(E2)、孕酮(PROG)、E2/PROG水平均明显下降(P<0.05~0.01);治疗组情志、月经、失眠变化积分与治疗前相比明显下降(P<0.05~0.01)。与对照组比较,治疗组的结节大小评分、疼痛变化评分、E2、PROG、E2/PROG、月经、情绪、失眠变化积分均明显下降(P<0.05)。2组患者的不良反应情况无统计学差异。结论从痰、郁论治乳腺多发结节,安全有效,可作为其重要治则。
OBJECTIVE To observe the clinical efficacy and safety of treating multiple breast nodules from phlegm and depression.METHODS 260 cases with multiple nodules patients were divided into treatment group(138 cases)and control group(122 cases)according to the random number table method.The treatment group was given the oral decoction of reducing phlegm and resolving masses,reliving liver qi stagnation.The control group was given oral Xiaojin capsules.The clinical efficacy and the change of nodules size,pain,sex hormone level,menstruation,emotions,insomnia and adverse reactions of the two groups were observed after treatment.RESULTS The clinical cure rate and total effective rate of the treatment group were significantly higher than that of control group(P<0.05).The score of nodule size,pain change,estradiol(E2),progesterone(PROG)and E2/PROG levels of two groups were significantly decreased after the treatment(P<0.05,P<0.01).The score of emotional,menstrual and insomnia changes of the treatment group were significantly decreased than that of berofre treatement(P<0.05,P<0.01).Compared with the control group,the score of nodule size,pain changes,E2,PROG,E2/PROG,menstrual,emotional and insomnia changes of the treatment group were significantly decreased(P<0.05).There was no significant difference between the two groups of the adverse reactions.CONCLUSION Treating multiple breast nodules from phlegm and depression is safe and effective and can be used as an important therapeutic principle.
OBJECTIVE To observe the clinical efficacy and safety of treating multiple breast nodules from phlegm and depression.METHODS 260 cases with multiple nodules patients were divided into treatment group(138 cases)and control group(122 cases)according to the random number table method.The treatment group was given the oral decoction of reducing phlegm and resolving masses,reliving liver qi stagnation.The control group was given oral Xiaojin capsules.The clinical efficacy and the change of nodules size,pain,sex hormone level,menstruation,emotions,insomnia and adverse reactions of the two groups were observed after treatment.RESULTS The clinical cure rate and total effective rate of the treatment group were significantly higher than that of control group(P<0.05).The score of nodule size,pain change,estradiol(E2),progesterone(PROG)and E2/PROG levels of two groups were significantly decreased after the treatment(P<0.05,P<0.01).The score of emotional,menstrual and insomnia changes of the treatment group were significantly decreased than that of berofre treatement(P<0.05,P<0.01).Compared with the control group,the score of nodule size,pain changes,E2,PROG,E2/PROG,menstrual,emotional and insomnia changes of the treatment group were significantly decreased(P<0.05).There was no significant difference between the two groups of the adverse reactions.CONCLUSION Treating multiple breast nodules from phlegm and depression is safe and effective and can be used as an important therapeutic principle.
引文
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[8]张笑兴,罗志莲,邓翀.刮痧拔罐法治疗乳腺增生的临床疗效观察[J].广州中医药大学学报,2016,33(1):42-45.
[9]陈实功.外科正宗[M].上海:上海科学技术出版社,1989:1973.
[2]林毅,唐汉钧.现代中医乳房病学[M].北京:人民卫生出版社,2003:101-108.
[3]国家中医药管理局医政司.中医病证诊断疗效标准[S].北京:中国中医药出版社,2017:131-134.
[4]中华预防医学会妇女保健分会乳腺保健与乳腺疾病防治学组.乳腺增生症专家共识[J].中国实用外科杂志,2016,36(7):759.
[5]谢新华,何清湖.中医外科学[M].北京:人民卫生出版社,2011:248.
[6]赵海军,王娟,王全乐,等.对乳腺增生患者直径较小乳腺结节的定期随访结果的回顾性分析[J].中华妇幼临床医学杂志(电子版),2016,12(5):608-612.
[7]徐林语,王晓霞,司徒小新,等.乳腺微创旋切系统治疗多发乳腺小结节的效果及优势分析[J].中国普通外科杂志,2016,5(25):777-778.
[8]张笑兴,罗志莲,邓翀.刮痧拔罐法治疗乳腺增生的临床疗效观察[J].广州中医药大学学报,2016,33(1):42-45.
[9]陈实功.外科正宗[M].上海:上海科学技术出版社,1989:1973.