双硫仑抗肿瘤作用研究进展
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摘要
目的探讨双硫仑在肿瘤治疗研究的作用机制和临床应用情况。方法通过查阅Pubmed数据库、万方数据库、中国知网(CNKI)、维普期刊全文数据库,检索2000年1月至2018年4月有关研究双硫仑在肿瘤治疗方面的相关文献,归纳、分析并总结。结果与结论双硫仑可通过多种途径抑制肿瘤细胞生长或诱导肿瘤细胞凋亡,具有低价、安全的特点,在抗肿瘤领域具有广阔的研究前景。
Objective To investigate the mechanism and clinical application of disulfiram in the treatment of tumors.Methods The relevant literature on disulfiram in the treatment of cancer from January 2000 to April 2018 were retrieved from Pubmed database,Wanfang database, CNKI and VIP database, and then the literature was analyzed and summarized.Results and Conclusion Disulfiram can inhibit the growth of tumor cell or induce the apoptosis of tumor cell through various pathways, and it has the characteristics of low cost and high safety,which has broad research prospects in the field of anti-tumor.
Objective To investigate the mechanism and clinical application of disulfiram in the treatment of tumors.Methods The relevant literature on disulfiram in the treatment of cancer from January 2000 to April 2018 were retrieved from Pubmed database,Wanfang database, CNKI and VIP database, and then the literature was analyzed and summarized.Results and Conclusion Disulfiram can inhibit the growth of tumor cell or induce the apoptosis of tumor cell through various pathways, and it has the characteristics of low cost and high safety,which has broad research prospects in the field of anti-tumor.
引文
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[7]BURKITT MJ,BISHOP HS,MILNE L,et al.Dithiocarbamate Toxicity toward Thymocytes Involves Their Copper-Catalyzed Conversion to Thiuram Disulfides,Which Oxidize Glutathione in a Redox Cycle without the Release of Reactive Oxygen Species[J].Arch Biochem Biophys,1998,353(1):73-84.
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[11]TOMITA H,TANAKA K,TANAKA T,et al.Aldehyde dehydrogenase 1 A1 in stem cells and cancer[J].Oncotarget,2016,7(10):11018-11032.
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[14]史鹏程,张妍琰,查洁,等.双硫仑/铜通过MAPK通络诱导凋亡逆转白血病细胞多柔吡星耐药的研究[J].中华肿瘤防治杂志,2012,19(8):566-569.
[15]杨亚萍,汪亚帷,李梦佳,等.DSF-Cu通过影响线粒体功能和细胞骨架诱导鼻咽癌CNE-2Z细胞凋亡[J].中国药理学通报,2016,32(9):1208-1217.
[16]YIP NC,FOMBON IS,LIU P,et al.Disulfiram modulated ROS-MAPK and NFkB pathways and targeted breast cancer cells with cancer stem cell-like properties[J].Br J Cancer,2011,104(10):1564-1574.
[17]殷文静,易菁,赵君,等.双硫仑和顺铂通过内质网应激途径协同抗宫颈癌的实验研究[J].中国妇幼保健,2014,29(12):1908-1911.
[18]TRISCOTT J,LEE C,HU K,et al.Disulfiram,a drug widely used to control alcoholism,suppresses self-renewal of glioblastoma and overrides resistance to temozolomide[J].Oncotarget,2012,3(10):1112-1123.
[19]LIU P,BROWN S,GOKTUG T,et al.Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells[J].Br J Cancer,2012,107(9):1488-1497.
[20]查洁,周勇,邓漫漫,等.双硫仑联合Cu抑制伯基特淋巴瘤Raji细胞移植瘤生长的动物实验[J].肿瘤研究与临床,2016,28(8):505-508.
[21]JIN N,ZHU X,CHENG F,et al.Disulfiram/copper targets stem cell-like ALDH+population of multiple myeloma by inhibition of ALDH1A1 and Hedgehog pathwayem[J].J Cell Biochem,2018,119(8):6882-6893.
[22]MORRISON BW,DOUDICAN NA,PATEL KR,et al.Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma[J].Melanoma Res,2010,20(1):11-20.
[23]SHARMA V,VERMA V,LAL N,et al.Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptorβ[J].Mol Carcinog,2016,55(11):1843-1857.
[24]SCHWEIZER MT,LIN J,BLACKFORD A,et al.Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer[J].Prostate Cancer Prostatic Dis,2013,16(4):357-361.
[25]LIN J,HAFFNER MC,ZHANG Y,et al.Disulfiram is a DNAdemethylating agent and inhibits prostate cancer cell growth[J].Prostate,2011,71(4):333-343.
[2]王诗韵,查洁,董慧娟,等.DS/Cu对急性髓系白血病干细胞增殖与凋亡影响及其机制的探讨[J].中华肿瘤防治杂志,2013,20(6):411-415.
[3]CVEK B,MILACIC V,TARABA J,et al.Ni(Ⅱ),Cu(Ⅱ),and Zn(Ⅱ)Diethyldithiocarbamate Complexes Show Various Activities Against the Proteasome in Breast Cancer Cells[J].J Med Chem,2008,51(20):6256-6258.
[4]LI LH,JY H,CHEN D,et al.Disulfiram promotes the conversion of carcinogenic cadmium to a proteasome inhibitor with proapoptotic activity in human cancer cells[J].Toxicol Appl Pharmacol,2008,229(2):206-214.
[5]CHEN D,CUI QC,YANG H,et al.Disulfiram,a clinically used anti-alcoholism drug and copper-binding agent,induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity[J].Cancer Res,2006,66(21):10425-10433.
[6]YU Z,WANG F,MILACIC V,et al.Evaluation of copper-dependent proteasome-inhibitory and apoptosis-inducing activities of novel pyrrolidine dithiocarbamate analogues[J].Int J Mol Med,2007,20(6):919-925.
[7]BURKITT MJ,BISHOP HS,MILNE L,et al.Dithiocarbamate Toxicity toward Thymocytes Involves Their Copper-Catalyzed Conversion to Thiuram Disulfides,Which Oxidize Glutathione in a Redox Cycle without the Release of Reactive Oxygen Species[J].Arch Biochem Biophys,1998,353(1):73-84.
[8]ALISON MR,LIN WR,LIM SM,et al.Cancer stem cells:in the line of fire[J].Cancer Treat Rev,2012,38(6):589-598.
[9]KOPPAKA V,THOMPSON DC,CHEN Y,et al.Aldehyde Dehydrogenase Inhibitors:a Comprehensive Review of the Pharmacology,Mechanism of Action,Substrate Specificity,and Clinical Application[J].Pharmacol Rev,2012,64(3):520-539.
[10]SHEN ML,LIPSKY JJ,NAYLOR S.Role of Disulfiram in the In Vitro Inhibition of Rat Liver Mitochondrial Aldehyde Dehydrogenase[J].Biochem Pharmacol,2000,60(7):947-953.
[11]TOMITA H,TANAKA K,TANAKA T,et al.Aldehyde dehydrogenase 1 A1 in stem cells and cancer[J].Oncotarget,2016,7(10):11018-11032.
[12]D'ARCY P,LINDER S.Proteasome deubiquitinases as novel targets for cancer therapy[J].Int J Biochem Cell Biol,2012,44(11):1729-1738.
[13]SHIAN SG,KAO YR,WU FY,et al.Y Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram[J].Mol Pharmacol,2003,64(5):1076-1084.
[14]史鹏程,张妍琰,查洁,等.双硫仑/铜通过MAPK通络诱导凋亡逆转白血病细胞多柔吡星耐药的研究[J].中华肿瘤防治杂志,2012,19(8):566-569.
[15]杨亚萍,汪亚帷,李梦佳,等.DSF-Cu通过影响线粒体功能和细胞骨架诱导鼻咽癌CNE-2Z细胞凋亡[J].中国药理学通报,2016,32(9):1208-1217.
[16]YIP NC,FOMBON IS,LIU P,et al.Disulfiram modulated ROS-MAPK and NFkB pathways and targeted breast cancer cells with cancer stem cell-like properties[J].Br J Cancer,2011,104(10):1564-1574.
[17]殷文静,易菁,赵君,等.双硫仑和顺铂通过内质网应激途径协同抗宫颈癌的实验研究[J].中国妇幼保健,2014,29(12):1908-1911.
[18]TRISCOTT J,LEE C,HU K,et al.Disulfiram,a drug widely used to control alcoholism,suppresses self-renewal of glioblastoma and overrides resistance to temozolomide[J].Oncotarget,2012,3(10):1112-1123.
[19]LIU P,BROWN S,GOKTUG T,et al.Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells[J].Br J Cancer,2012,107(9):1488-1497.
[20]查洁,周勇,邓漫漫,等.双硫仑联合Cu抑制伯基特淋巴瘤Raji细胞移植瘤生长的动物实验[J].肿瘤研究与临床,2016,28(8):505-508.
[21]JIN N,ZHU X,CHENG F,et al.Disulfiram/copper targets stem cell-like ALDH+population of multiple myeloma by inhibition of ALDH1A1 and Hedgehog pathwayem[J].J Cell Biochem,2018,119(8):6882-6893.
[22]MORRISON BW,DOUDICAN NA,PATEL KR,et al.Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma[J].Melanoma Res,2010,20(1):11-20.
[23]SHARMA V,VERMA V,LAL N,et al.Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptorβ[J].Mol Carcinog,2016,55(11):1843-1857.
[24]SCHWEIZER MT,LIN J,BLACKFORD A,et al.Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer[J].Prostate Cancer Prostatic Dis,2013,16(4):357-361.
[25]LIN J,HAFFNER MC,ZHANG Y,et al.Disulfiram is a DNAdemethylating agent and inhibits prostate cancer cell growth[J].Prostate,2011,71(4):333-343.