内源性大麻素系统在非酒精性脂肪性肝病发生中的作用
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摘要
本文通过用"非酒精性脂肪性肝病(NAFLD)""内源性大麻素受体""粘膜屏障"等中英文关键词对CNKI、Pubmed数据库进行文献检索,综述内源性大麻素系统(ECS)的受体、配体及其介导的肠粘膜屏障功能在NAFLD发生中的作用及机制,为NAFLD防治提供新的干预靶点。
This paper,by using "nonalcoholic fatty liver disease(NAFLD)" "endogenous cannabinoid receptors" "mucous membrane barrier" and other key words in both English and Chinese on CNKI,Pubmed database literature retrieval,reviews the endogenous cannabinoid system(ECS),ligands and their receptors mediated the intestinal mucosal barrier function in the role and mechanism of NAFLD,and provide new targets for intervention for prevention and control of NAFLD.
This paper,by using "nonalcoholic fatty liver disease(NAFLD)" "endogenous cannabinoid receptors" "mucous membrane barrier" and other key words in both English and Chinese on CNKI,Pubmed database literature retrieval,reviews the endogenous cannabinoid system(ECS),ligands and their receptors mediated the intestinal mucosal barrier function in the role and mechanism of NAFLD,and provide new targets for intervention for prevention and control of NAFLD.
引文
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[23]PACHER P,MECHOULAM R.Is lipid signaling through cannabinoid2 receptors part of a protective system?[J].Prog Lipid Res,2011,50(2):193-211.
[24]POETA M,PIERRI L,VAJRO P.Gut-Liver Axis Derangement in Non-Alcoholic Fatty Liver Disease[J].Children(Basel),2017,4(8):66.
[25]MARRA F,SVEGLIATI-BARONI G.Lipotoxicity and the gut-liver axis in NASH pathogenesis[J].J Hepatol,2018,68(2):280-295.
[26]SHEN F,ZHENG RD,SUN XQ,et al.Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease[J].Hepatobiliary Pancreat Dis Int,2017,16(4):375-381.
[27]QIN J,LI R,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[28]WRIGHT KL,DUNCAN M,SHARKEY KA.Cannabinoid CB2 receptors in the gastrointestinal tract:a regulatory system in states of inflammation[J].Br J Pharmacol,2008,153(2):263-270.
[29]MUCCIOLI GG,NASLAIN D,BACKHED F,et al.The endocannabinoid system links gut microbiota to adipogensis[J/OL].Mol Syst Biol,2010,6:392.[2018-11-01].http://msb.embopress.org/content/6/1/392.long.DOI:10.1038/msb.2010.46.
[30]EVERARD A,LAZAREVIC V,DERRIEN M et al.Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice[J].Diabetes,2011,60(11):2775-2786.
[2]DAY CP,JAMES OF.Steatohepatitis:a tale of two“hits”?[J].Gastoenterology,1998,114(4):842-845.
[3]TILG H,MOSCHEN AR.Evolution of inflammation in nonalcoholic fatty liver disease:the multiple parallel hits hypothesis[J].Hepatology,2010,52(5):1836-1846.
[4]CANI PD,PLOVIER H,VAN HUL M,et al.Endocannabinoids-at the crossroads between the gut microbiota and host metabolism[J].Nat Rev Endocrinol,2016,12(3):133-143.
[5]MACCARRONE M,BAB R,BIRO T,et al.Endocannabinoid signaling at the periphery:50 years after THC[J].Trends Pharmacol Sci,2015,36(5):277-296.
[6]CARR RL,BORAZJANI A,ROSS MK.Effect of developmental chlorpyrifos exposure,on endocannabinoid metabolizing enzymes,in the brain of juvenile rats[J].Toxicol Sci,2011,122(1):112-120.
[7]BLANKMAN JL,CRAVATT BF.Chemical probes of endocannabinoid metabolism[J].Pharmacol Rev,2013,65(2):849-871.
[8]S魣NCHEZ AJ,GARC魱A-MERINO A.Neuroprotective agents:cannabinoids[J].Clin Immunol,2012,142(1):57-67.
[9]CARDINAL P1,BELLOCCHIO L,CLARK S,et al.Hypothalamic CB1cannabinoid receptors regulate energy balance in mice[J].Endocrinology,2012,153(9):4136-4143.
[10]TURCOTTE C,BLANCHET MR,LAVIOLETTE M,et al.The CB2 receptor and its role as a regulator of inflammation[J].Cell Mol Life Sci,2016,73(23):4449-4470.
[11]MALLAT A,TEIXEIRA-CLERC F,LOTERSZTAJN S.Cannabinoid signaling and liver therapeutics[J].J Hepatol,2013,59(4):891-896.
[12]TEIXEIRA-CLERC F,BELOT MP,MANIN S,et al.Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration[J].Hepatology,2010,52(3):1046-1059.
[13]JOURDAN T,DEMIZIEUX L,GRESTI J,et al.Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice:Evidence from cultured explants[J].Hepatology,2012,55(3):790-799.
[14]TAM J,VEMURI VK,LIU J,et al.Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity[J].J Clin Invest,2010,120(8):2953-2966.
[15]LIU J,ZHOU L,XIONG K,et al.Hepatic cannabinoid receptor-1 mediates dietinduced insulin resistance via inhibition of insulin signaling and clearance in mice[J].Gastroenterology,2012,142(5):1218-1228.
[16]CHANDA D,KIM YH,KIM DK,et al.Activation of cannabinoid receptor type 1(Cb1r)disrupts hepatic insulin receptor signaling via cyclic AMPresponse element-binding protein H(Crebh)-mediated induction of Lipin1 gene.J Biol Chem[J].J Biol Chem,2012,287(45):38041-38049.
[17]JOURDAN T,DJAOUTI L,DEMIZIEUX L et al.CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice[J].Diabetes,2010,59(4):926-934.
[18]CINAR R1,GODLEWSKI G,LIU J,et at.Hepatic cannabinoid-1receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides[J].Hepatology,2014,59(1):143-153.
[19]DAI E,ZHANG L,YE L,et at.Hepatic expression of cannabinoid receptors CB1 and CB2 correlate with fibrogenesis in patients with chronic hepatitis B[J/OL].Int J Infect Dis,2017,59:124-130.[2018-09-29].https://www.ijidonline.com/article/S1201-9712(17)30091-7/fulltext.DOI:10.1016/j.ijid.2017.03.008.
[20]JULIEN B,GRENARD P,TEIXEIRA-CLERC F et al.Antifibrogenic role of the cannabinoid receptor CB2 in the liver[J].Gastroenterology,2005,128(3):742-755.
[21]GUILLOT A,HAMDAOUI N,BIZY A,et al.Cannabinoid receptor 2counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver[J].Hepatology,2014,59(1):296-306.
[22]LOUVET A,TEIXEIRA-CLERC F,CHOBERT MN,et al.Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice[J].Hepatology,2011,54(4):1217-1226.
[23]PACHER P,MECHOULAM R.Is lipid signaling through cannabinoid2 receptors part of a protective system?[J].Prog Lipid Res,2011,50(2):193-211.
[24]POETA M,PIERRI L,VAJRO P.Gut-Liver Axis Derangement in Non-Alcoholic Fatty Liver Disease[J].Children(Basel),2017,4(8):66.
[25]MARRA F,SVEGLIATI-BARONI G.Lipotoxicity and the gut-liver axis in NASH pathogenesis[J].J Hepatol,2018,68(2):280-295.
[26]SHEN F,ZHENG RD,SUN XQ,et al.Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease[J].Hepatobiliary Pancreat Dis Int,2017,16(4):375-381.
[27]QIN J,LI R,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[28]WRIGHT KL,DUNCAN M,SHARKEY KA.Cannabinoid CB2 receptors in the gastrointestinal tract:a regulatory system in states of inflammation[J].Br J Pharmacol,2008,153(2):263-270.
[29]MUCCIOLI GG,NASLAIN D,BACKHED F,et al.The endocannabinoid system links gut microbiota to adipogensis[J/OL].Mol Syst Biol,2010,6:392.[2018-11-01].http://msb.embopress.org/content/6/1/392.long.DOI:10.1038/msb.2010.46.
[30]EVERARD A,LAZAREVIC V,DERRIEN M et al.Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice[J].Diabetes,2011,60(11):2775-2786.