左西孟旦治疗急性心力衰竭的临床效果及其对血清脑钠肽的影响
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摘要
目的观察左西孟旦在急性心力衰竭患者中的应用效果,及其对患者血清脑钠肽的影响。方法选取2017年10月—2018年10月收治的急性心力衰竭患者74例,根据治疗方法的差异设置观察组和对照组,对照组实施盐酸多巴酚丁胺注射液治疗,观察组实施左西孟旦治疗。结果治疗后,两组血清脑钠肽比较有显著统计学差异(P <0. 05);两组不良反应的比较有显著统计学差异(P <0. 05);两组疗效的比较有显著统计学差异(P <0. 05)。结论左西孟旦能够改善急性心力衰竭患者的血清脑钠肽,减少患者治疗后的心悸、胸痛等不良反应,从整体上提高疾病的临床治疗效果。
Objective To observe the effect of levosimendan in patients with acute heart failure and its effect on serum brain natriuretic peptide( BNP). Methods 74 patients with acute heart failure received in our hospital from October2017 to October 2018 were selected. According to the difference of treatment methods,observation group and control group were set up. The control group was treated with dobutamine hydrochloride injection,while the observation group was treated with levosimendan. Results There was no statistical significance of serum brain natriuretic peptide between the observation group and the control group before treatment( P > 0. 05),and there was significant difference between the two groups after treatment( P < 0. 05). There was a significant difference in adverse reactions between the two groups after treatment( P <0. 05). There was a significant difference in the therapeutic effect between the two groups( P < 0. 05). Conclusion Levosimendan can improve the serum brain natriuretic peptide in patients with acute heart failure,reduce the adverse reactions such as palpitation and chest pain after treatment,and improve the clinical therapeutic effect of the disease as a whole.
Objective To observe the effect of levosimendan in patients with acute heart failure and its effect on serum brain natriuretic peptide( BNP). Methods 74 patients with acute heart failure received in our hospital from October2017 to October 2018 were selected. According to the difference of treatment methods,observation group and control group were set up. The control group was treated with dobutamine hydrochloride injection,while the observation group was treated with levosimendan. Results There was no statistical significance of serum brain natriuretic peptide between the observation group and the control group before treatment( P > 0. 05),and there was significant difference between the two groups after treatment( P < 0. 05). There was a significant difference in adverse reactions between the two groups after treatment( P <0. 05). There was a significant difference in the therapeutic effect between the two groups( P < 0. 05). Conclusion Levosimendan can improve the serum brain natriuretic peptide in patients with acute heart failure,reduce the adverse reactions such as palpitation and chest pain after treatment,and improve the clinical therapeutic effect of the disease as a whole.
引文
[1]武星君,官庆妮,杨红萍,等.左西孟旦对急性心力衰竭病人心功能及血清BNP,IL-6,TNF-α,hs-CRP水平的影响[J].中西医结合心脑血管病杂志,2018,22(3):326-329.
[2]王保才,葛振伟,程兆云,等.左西孟旦治疗急性失代偿心力衰竭疗效及对患者BNP、CRP、IL-6水平的影响[J].中国医院药学杂志,2017,37(20):2081-2084.
[3]急性心力衰竭诊断和治疗指南专家组.急性心力衰竭诊断和治疗指南[J].中国心血管病研究,2011,9(2):81-97.
[4]贺利平,郭媛博,包龙棠,等.心力衰竭患者应用左西孟旦治疗对心功能及BNP、hs-CRP的影响[J].检验医学与临床,2016,13(24):3563-3565.
[5]俞瑞群,王丹,吴晓蓉,等.左西孟旦治疗老年慢性心力衰竭急性加重患者的临床疗效[J].实用心脑肺血管病杂志,2018,22(5):88-90.
[6]王晓芳.左西孟旦对老年扩张型心肌病急性心力衰竭患者心肌功能与相关免疫指标的影响[J].实用老年医学,2016,21(8):668-671.
[7]刘睿,邢玉,李荣,等.左西孟旦联合托伐普坦在急性失代偿性心力衰竭中的应用[J].实用医学杂志,2017,33(18):3107-3109.
[8]罗刚,袁文金.重组人脑利钠肽治疗难治性心力衰竭的疗效观察[J].现代医院,2017,17(9):1349-1351.
[9]钟敬琼,李少霞,许珍娥.麝香通心滴丸联合左卡尼汀治疗慢性心力衰竭的临床疗效观察[J].现代医院,2017,17(1):101-102.
[10]曹军.急性心力衰竭45例应用左西孟旦进行治疗的效果观察[J].中国现代药物应用,2016,10(15):11-12.
[2]王保才,葛振伟,程兆云,等.左西孟旦治疗急性失代偿心力衰竭疗效及对患者BNP、CRP、IL-6水平的影响[J].中国医院药学杂志,2017,37(20):2081-2084.
[3]急性心力衰竭诊断和治疗指南专家组.急性心力衰竭诊断和治疗指南[J].中国心血管病研究,2011,9(2):81-97.
[4]贺利平,郭媛博,包龙棠,等.心力衰竭患者应用左西孟旦治疗对心功能及BNP、hs-CRP的影响[J].检验医学与临床,2016,13(24):3563-3565.
[5]俞瑞群,王丹,吴晓蓉,等.左西孟旦治疗老年慢性心力衰竭急性加重患者的临床疗效[J].实用心脑肺血管病杂志,2018,22(5):88-90.
[6]王晓芳.左西孟旦对老年扩张型心肌病急性心力衰竭患者心肌功能与相关免疫指标的影响[J].实用老年医学,2016,21(8):668-671.
[7]刘睿,邢玉,李荣,等.左西孟旦联合托伐普坦在急性失代偿性心力衰竭中的应用[J].实用医学杂志,2017,33(18):3107-3109.
[8]罗刚,袁文金.重组人脑利钠肽治疗难治性心力衰竭的疗效观察[J].现代医院,2017,17(9):1349-1351.
[9]钟敬琼,李少霞,许珍娥.麝香通心滴丸联合左卡尼汀治疗慢性心力衰竭的临床疗效观察[J].现代医院,2017,17(1):101-102.
[10]曹军.急性心力衰竭45例应用左西孟旦进行治疗的效果观察[J].中国现代药物应用,2016,10(15):11-12.