强迫症患者认知电位P300研究的Meta分析
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摘要
目的:评价中国强迫症患者的认知相关电位P300波幅和潜伏期是否存在异常。方法:检索Pub Med、Web of knowledge、Cochrane Library、中国知网全文数据库、万方数据库、维普中文科技期刊数据库及中国生物医学文献光盘数据库等电子数据库中关于强迫症中国患者与正常对照P300相比较的文献,检索时间为1978年-2014年5月。采用Stata软件对P300波幅和潜伏期进行Meta分析。结果:共有8项研究符合入组标准进行Meta分析。随机效应模型合并分析,结果显示,强迫症患者组的P300波幅低于正常对照组[总效应Z=6.64,合并SMD=-0.970,95%CI(-1.264,0.676),P<0.00001],而潜伏期大于正常对照组[总效应Z=2.32,合并SMD=0.467,95%CI(0.071,0.863),P=0.021]。结论:P300能够反映强迫症患者事件相关电位的损害,可以作为综合评估强迫症患者认知功能损害的客观指标。
Objective: To evaluate the abnormality of cognitive event- related potential P300 amplitude and latency in Chinese patients with obsessive- compulsive disorder. Methods: All searches were made in Pub Med,EMBase,Web of knowledge,Cochrane Library,Psyc INFO,National Knowledge Infrastructure( CNKI),Wanfang Data,VIP Database for Chinese Technical Periodicals and Chinese Biomedicine( CBM) Disc databases. All of the literatures related to P300 studies in obsessive- compulsive disorder were searched form 1979 to 2014. Stata 11. 0 was used for Meta analysis. Results: Eight studies that met the inclusion and exclusion criteria were included in the Meta analysis. Random effects meta- analysis showed that P300 amplitude was lower in the patient group compared with the control group[overall effect Z = 6. 64,SMD =-0. 970,95% CI(-1. 264,0. 676),P < 0. 00001]. P300 latency was longer in patients than that in controls[overall effect Z = 2. 32,SMD = 0. 467,95% CI( 0. 071,0. 863),P = 0. 021].Conclusion: These results suggest that P300 can reflect cognitive function in patients with obsessive-compulsive disorder. The amplitude and latency can be objective indicators to assess the cognitive impairment in patients with obsessive- compulsive disorder.
Objective: To evaluate the abnormality of cognitive event- related potential P300 amplitude and latency in Chinese patients with obsessive- compulsive disorder. Methods: All searches were made in Pub Med,EMBase,Web of knowledge,Cochrane Library,Psyc INFO,National Knowledge Infrastructure( CNKI),Wanfang Data,VIP Database for Chinese Technical Periodicals and Chinese Biomedicine( CBM) Disc databases. All of the literatures related to P300 studies in obsessive- compulsive disorder were searched form 1979 to 2014. Stata 11. 0 was used for Meta analysis. Results: Eight studies that met the inclusion and exclusion criteria were included in the Meta analysis. Random effects meta- analysis showed that P300 amplitude was lower in the patient group compared with the control group[overall effect Z = 6. 64,SMD =-0. 970,95% CI(-1. 264,0. 676),P < 0. 00001]. P300 latency was longer in patients than that in controls[overall effect Z = 2. 32,SMD = 0. 467,95% CI( 0. 071,0. 863),P = 0. 021].Conclusion: These results suggest that P300 can reflect cognitive function in patients with obsessive-compulsive disorder. The amplitude and latency can be objective indicators to assess the cognitive impairment in patients with obsessive- compulsive disorder.
引文
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[15]王晓燕,陈斌,朱熊兆,等.强迫症患者GO/NOGO任务的事件相关电位研究[J].中国心理卫生杂志,2008,22(4):276-280
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[18]乔娟,龚广厚,赵厚锋,等.强迫症患者听觉事件相关电位P300的研究[J].神经疾病与精神卫生,2014,14(1):58-60
[19]刘青蕊.实用临床电生理学[M].北京:中国科学技术出版社,2006:108-109
[20]Kim Ms,Kang SS,Youn T,et al.Neuropsychological correlates of P300 abnomalities in patients with schizophrenia and obsessive compulsive disorder[J].Psychiatry Res,2003,123(2):109-123
[21]Mavrogiorgou P,Juckel G,Frodl T,et al.P300 subcomponents in obsessive-compulsive disorder[J].J Psychiatry Res,2002,36(6):399-406
[22]张玉娟,张朝辉,穆俊林.神经心理测定和事件相关电位P300对躯体化障碍认知功能的评价作用研究[J].中国健康心理学杂志,2012,20(3):453-455
[23]Morault P M,Bourgeios M,Laville J,et al.Psychophyiological and cllnical value of event-related potentials in obsessive compulsive disorder[J].Biol Psychiatry,1997,42(1):46-56
[24]蔡亦蕴,苏亮,徐一峰,等.中国广泛性焦虑症患者认知电位P300研究的Meta分析[J].中国神经精神疾病杂志,2013,39(3):174-178
[25]Reese C,Polich J.Alcoholism risk and the P300 event-related brain potential:Modality,task,and gender effects[J].Brain Cogn,2003,53(1):46-57
[26]彭焱,李建明,王健.慢性精神分裂症事件相关电位P300与认知功能成套测验的研究[J].中国健康心理学杂志,2009,17(9):1025-1028
[27]张广亚,张理义,陶凤燕.精神分裂症事件相关电位P300与心理症状的相关性研究[J].中国健康心理学杂志,2010,18(7):775-777
[2]惠存竹,苏旭江.帕利哌酮对强迫症治疗的增效作用研究[J].中国健康心理学杂志,2014,22(1):1-2
[3]易峰,苏旭江,汪艳.躯体形式障碍患者认知功能情况与事件相关电位P300的研究[J].中国健康心理学杂志,2012,20(12):1829-1831
[4]Karl A,Malta L S,Maercker A.Meta-analytic review of event-related potential studies inpost-traumatic stress disorder[J].Biol Psychol,2006,71(2):123-147
[5]The Cochrane Collaboration.Cochrane Handbook for Systematic Reviews of Interventions.[EB/OL]http://www.cochrane.org/training/cochrane-handbook
[6]Lichtenstein M,Mulrow C,Elwood P.Guidelines for reading casecontrol studies[J].JChronic Dis,1987,40(9):893-903
[7]Bramon E,Rabe-Hesketh S,Sham P,et al.Meta-analysis of the P300 and P50 waveforms in schizophrenia[J].Schizophr Res,2004,70(2-3):315-329
[8]Elm E,Altman D,Egger M,et al.加强流行病学中观察性研究报告质量(STROBE)声明:观察性研究报告规范[J].世界临床医学:柳叶刀中文版,2008,2(1):78-82
[9]苏亮,胡华,陈静,等.精神分裂症患者感觉门控P50电位研究的系统评价[J].中华医学杂志,2010,90(29):2020-2025
[10]Rosenberg M.The file-drawer problem revisited:A general weighted method for calculating fail-safe numbers in meta-analysis[J].Evolution,2005,59(2):464-468
[11]庄丽频,冯永铭,陈毓麒等.强迫症患者事件相关电位P300临床纵向研究[J].中国心理卫生杂志,2001,15(4):237-240
[12]肖泽萍,陈兴时,张明岛,等.强迫症,抑郁症及焦虑症患者事件相关电位的比较研究[J].中华精神科杂志,2003,36(2):81-84
[13]肖泽萍,陈兴时,张明岛,等.强迫症患者治疗前后脑诱发电位的比较研究[J].中华精神科杂志,2004,37(2):92-95
[14]马锦堂,王彦芳.精神分裂症抑郁症焦虑症强迫症患者事件相关电位P300的比较分析[J].山西医药杂志,2005,34(5):410-411
[15]王晓燕,陈斌,朱熊兆,等.强迫症患者GO/NOGO任务的事件相关电位研究[J].中国心理卫生杂志,2008,22(4):276-280
[16]Yingzhi Lu,Wenbin Zong,Hanzhen Dong,et al.Characterization of event-related potentials in obsessive compulsive disorder patients[J].Neural Regeneration Research,2010,5(12):938-941
[17]张惠芳,方向明,张凤林,等.广泛性焦虑与强迫症患者事件相关电位P300的比较研究[J].现代实用医学,2011,23(1):41-43
[18]乔娟,龚广厚,赵厚锋,等.强迫症患者听觉事件相关电位P300的研究[J].神经疾病与精神卫生,2014,14(1):58-60
[19]刘青蕊.实用临床电生理学[M].北京:中国科学技术出版社,2006:108-109
[20]Kim Ms,Kang SS,Youn T,et al.Neuropsychological correlates of P300 abnomalities in patients with schizophrenia and obsessive compulsive disorder[J].Psychiatry Res,2003,123(2):109-123
[21]Mavrogiorgou P,Juckel G,Frodl T,et al.P300 subcomponents in obsessive-compulsive disorder[J].J Psychiatry Res,2002,36(6):399-406
[22]张玉娟,张朝辉,穆俊林.神经心理测定和事件相关电位P300对躯体化障碍认知功能的评价作用研究[J].中国健康心理学杂志,2012,20(3):453-455
[23]Morault P M,Bourgeios M,Laville J,et al.Psychophyiological and cllnical value of event-related potentials in obsessive compulsive disorder[J].Biol Psychiatry,1997,42(1):46-56
[24]蔡亦蕴,苏亮,徐一峰,等.中国广泛性焦虑症患者认知电位P300研究的Meta分析[J].中国神经精神疾病杂志,2013,39(3):174-178
[25]Reese C,Polich J.Alcoholism risk and the P300 event-related brain potential:Modality,task,and gender effects[J].Brain Cogn,2003,53(1):46-57
[26]彭焱,李建明,王健.慢性精神分裂症事件相关电位P300与认知功能成套测验的研究[J].中国健康心理学杂志,2009,17(9):1025-1028
[27]张广亚,张理义,陶凤燕.精神分裂症事件相关电位P300与心理症状的相关性研究[J].中国健康心理学杂志,2010,18(7):775-777