款冬酮研究进展
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摘要
款冬酮是从中药款冬花中分离得到的一种倍半萜类成分,中国药典2015年版收载的款冬花的含量测定指标成分即为款冬酮。本文对款冬酮的提取工艺、分离方法、结构鉴定、含量检测、药理活性进行综述,为款冬酮的深入研究及开发利用提供参考。
Tussilagone is a kind of sesquiterpene, which is separated from Chinese traditional medicine Tussilago farfara L., the index of the content determination of Tussilago farfara L. in the Chinese Pharmacopoeia 2015 edition is called tussilagone. In this paper, the extraction technology, separation method, structure identification, content detection and pharmacological activity of tussilagone are reviewed in order to provide a reference for the further research and development of the tussilagone.
Tussilagone is a kind of sesquiterpene, which is separated from Chinese traditional medicine Tussilago farfara L., the index of the content determination of Tussilago farfara L. in the Chinese Pharmacopoeia 2015 edition is called tussilagone. In this paper, the extraction technology, separation method, structure identification, content detection and pharmacological activity of tussilagone are reviewed in order to provide a reference for the further research and development of the tussilagone.
引文
[1]肖培根.新编中药志[M].第II版.北京:化学工业出版社,2002:802,805.
[2]LIU J,PEI L,SUN G Q,et al.Herbal authentication on Farfarae Flos[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(2):204-208.
[3]WU Q Z,ZHANG C F,XU X H,et al.Advances in the chemical constituents and biological activities of the flower buds of Tussilago farfara[J].Chin Wild Plant Res(中国野生植物资源),2015,34(2):33-36.
[4]YING B P,YANG P M,ZHU R H,et al.Studies on the constituents of Tussilago farfara L.I.Structure of tussilagone[J].J Chin Chem Soc(化学学报),1987,45(5):450-455.
[5]LIU Y F,YANG X W.RP-HPLC determination of tussilagone in Flos Farfarae[J].Chin J Pharm Anal(药物分析杂志),2009,29(1):31-34.
[6]郑兴宇,马致洁,董红红,等.款冬花中款冬酮超临界CO2萃取研究[C].全国中药和天然药物学术研讨会,2009:906-908.
[7]曹坤,徐溢.款冬花活性化学成分分离及款冬酮提取工艺研究[C].2013年中国化学会产学研合作研讨会会议,2013:59-60.
[8]LU X Y,CAO J.Studies on the quality standards of Kuandonghua in pharmacopoeia[J].West J Chin Med(西部中医药),2015,28(2):30-33.
[9]WANG,FANG D J,WANG L,et al.Preparative separation and purification of sesquiterpenoids from Tussilago farfara L.by high-speed counter-current chromatography[J].Química Nova,2011,34(5):804-807.
[10]韩聪聪.款冬花中萜类和黄酮类化合物分离技术研究[D].重庆:重庆大学,2015.
[11]张志伟,马致洁,董红红,等.不同产地款冬花中款冬酮的测定[J].中草药,2009,40(s1):284-286.
[12]王国艳.毛细管电泳技术在款冬花质量控制中的分析应用[D].太原:山西医科大学,2013.
[13]曹坤.款冬花化学成分分离分析和质量控制指标研究[D].重庆:重庆大学,2016.
[14]WU D,ZHANG C F,ZHANG M,et al.Study on chemical constituents of the flower buds of Tussilago farfara[J].Chin Pharm J(中国药学杂志),2008,43(4):260-263.
[15]LI Y P,WANG Y M.Evaluation of tussilagone:a cardiovascular-respiratory stimulant isolated from Chinese herbal medicine[J].General Pharmacol,1988,19(2):261.
[16]李一平,王筠默.款冬酮的升压机制[J].中国药理学报,1986,7(4):333-336.
[17]李一平,王筠默.款冬酮对清醒狗和失血性休克狗血流动力学的影响[J].药学学报,1987(7):486-490.
[18]HAN G Q,YANG Y J,LI C L.the investigation of principles against platelet activating factor(PAF)from Tussilago farfara L.[J].J Beijing Med Univ(北京医科大学学报),1987,19(1):33-35.
[19]LIM H J,DONG G Z,LEE H J,et al.In vitro neuroprotective activity of sesquiterpenoids from the flower buds of Tussilago farfara[J].J Enzyme Inhib Med Chem,2014,30(5):1-5.
[20]LIM H J,LEE H S,RYU J H.Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression by tussilagone from farfarae flos in BV-2 microglial cells[J].Arch Pharm Res,2008,31(5):645-652.
[21]HWANGBO C,LEE H S,PARK J,et al.The anti-inflammatory effect of tussilagone,from Tussilago farfara,is mediated by the induction of heme oxygenase-1 in murine macrophages.[J].Int Immunopharmacol,2009,9(13-14):1578-1584.
[22]LI Y F,CHEN X Y,XIONG W Y,et al.Antiallergic effect of tussilagone from Tussilago farfara L.[J].Chin J New Drugs(中国新药杂志),2015,24(13):1517-1522.
[23]HYE R P,MI Y Y,JEE,H S,et al.Sesquiterpenoids isolated from the flower buds of Tussilago farfara L.inhibit diacylglycerol acyltransferase[J].J Agric Food Chem,2008,56(22):10493-10497.
[24]LI H,LEE H J,AHN Y H,et al.Tussilagone suppresses colon cancer cell proliferation by promoting the degradation of β-catenin.[J].Biochem Biophys Res Commun,2014,443(1):132-137.
[2]LIU J,PEI L,SUN G Q,et al.Herbal authentication on Farfarae Flos[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(2):204-208.
[3]WU Q Z,ZHANG C F,XU X H,et al.Advances in the chemical constituents and biological activities of the flower buds of Tussilago farfara[J].Chin Wild Plant Res(中国野生植物资源),2015,34(2):33-36.
[4]YING B P,YANG P M,ZHU R H,et al.Studies on the constituents of Tussilago farfara L.I.Structure of tussilagone[J].J Chin Chem Soc(化学学报),1987,45(5):450-455.
[5]LIU Y F,YANG X W.RP-HPLC determination of tussilagone in Flos Farfarae[J].Chin J Pharm Anal(药物分析杂志),2009,29(1):31-34.
[6]郑兴宇,马致洁,董红红,等.款冬花中款冬酮超临界CO2萃取研究[C].全国中药和天然药物学术研讨会,2009:906-908.
[7]曹坤,徐溢.款冬花活性化学成分分离及款冬酮提取工艺研究[C].2013年中国化学会产学研合作研讨会会议,2013:59-60.
[8]LU X Y,CAO J.Studies on the quality standards of Kuandonghua in pharmacopoeia[J].West J Chin Med(西部中医药),2015,28(2):30-33.
[9]WANG,FANG D J,WANG L,et al.Preparative separation and purification of sesquiterpenoids from Tussilago farfara L.by high-speed counter-current chromatography[J].Química Nova,2011,34(5):804-807.
[10]韩聪聪.款冬花中萜类和黄酮类化合物分离技术研究[D].重庆:重庆大学,2015.
[11]张志伟,马致洁,董红红,等.不同产地款冬花中款冬酮的测定[J].中草药,2009,40(s1):284-286.
[12]王国艳.毛细管电泳技术在款冬花质量控制中的分析应用[D].太原:山西医科大学,2013.
[13]曹坤.款冬花化学成分分离分析和质量控制指标研究[D].重庆:重庆大学,2016.
[14]WU D,ZHANG C F,ZHANG M,et al.Study on chemical constituents of the flower buds of Tussilago farfara[J].Chin Pharm J(中国药学杂志),2008,43(4):260-263.
[15]LI Y P,WANG Y M.Evaluation of tussilagone:a cardiovascular-respiratory stimulant isolated from Chinese herbal medicine[J].General Pharmacol,1988,19(2):261.
[16]李一平,王筠默.款冬酮的升压机制[J].中国药理学报,1986,7(4):333-336.
[17]李一平,王筠默.款冬酮对清醒狗和失血性休克狗血流动力学的影响[J].药学学报,1987(7):486-490.
[18]HAN G Q,YANG Y J,LI C L.the investigation of principles against platelet activating factor(PAF)from Tussilago farfara L.[J].J Beijing Med Univ(北京医科大学学报),1987,19(1):33-35.
[19]LIM H J,DONG G Z,LEE H J,et al.In vitro neuroprotective activity of sesquiterpenoids from the flower buds of Tussilago farfara[J].J Enzyme Inhib Med Chem,2014,30(5):1-5.
[20]LIM H J,LEE H S,RYU J H.Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression by tussilagone from farfarae flos in BV-2 microglial cells[J].Arch Pharm Res,2008,31(5):645-652.
[21]HWANGBO C,LEE H S,PARK J,et al.The anti-inflammatory effect of tussilagone,from Tussilago farfara,is mediated by the induction of heme oxygenase-1 in murine macrophages.[J].Int Immunopharmacol,2009,9(13-14):1578-1584.
[22]LI Y F,CHEN X Y,XIONG W Y,et al.Antiallergic effect of tussilagone from Tussilago farfara L.[J].Chin J New Drugs(中国新药杂志),2015,24(13):1517-1522.
[23]HYE R P,MI Y Y,JEE,H S,et al.Sesquiterpenoids isolated from the flower buds of Tussilago farfara L.inhibit diacylglycerol acyltransferase[J].J Agric Food Chem,2008,56(22):10493-10497.
[24]LI H,LEE H J,AHN Y H,et al.Tussilagone suppresses colon cancer cell proliferation by promoting the degradation of β-catenin.[J].Biochem Biophys Res Commun,2014,443(1):132-137.