中青年高血压患者血压水平与Hcy、UA、hsCRP的相关性分析
|
摘要
[目的]探讨中青年高血压患者血压水平与同型半胱氨酸(Hcy)、血尿酸(UA)、超敏C反应蛋白(hsCRP)的相关性。[方法]选取2017年8月至2018年11月就诊的中青年高血压患者68例,以血压水平分为高血压病1级组(23例),高血压病2级组(25例),高血压病3级组(20例),比较3组患者的一般资料,检测并比较3组Hcy、UA、hsCRP水平,分析其与血压水平的相关性。[结果]3组患者Hcy、UA、hsCRP的水平随着血压分级的升高而升高,3组间有统计学差异(P<0.01);进行两两比较,发现高血压病1级组与高血压病2级组,以及高血压病1级组与高血压病3级组Hcy、UA、hsCRP水平有统计学差异(P<0.05);经Pearson相关分析,血清Hcy、UA、hsCRP与收缩压水平呈正相关(r_1=0.573、r_2=0.706、r_3=0.711,P<0.01),Hcy、hsCRP与舒张压水平呈正相关(r_4=0.421、r_5=0.566,P<0.01)。[结论]中青年高血压患者中,Hcy、UA、hsCRP与血压水平相关,监测其水平并设法干预对高血压病的防治提供了思路及依据。
[Objective]To explore the correlation between blood pressure level and homocysteine(Hcy), serum uric acid(UA) and hypersensitive C-reactive protein(hsCRP) in young and middle-aged patients with hypertension. [Methods]Sixty-eight young and middle-aged hypertension patients treated from August 2017 to November 2018 were selected. According to the blood pressure level, they were divided into hypertension grade 1 group(23 cases), hypertension grade 2 group(25 cases) and hypertension grade 3 group(20 cases). The general data of three groups were compared. Hcy and UA and hsCRP level of three groups were detected and compared, and the relationship between these and blood pressure level was analyzed.[Results]With the increasing of blood pressure grade, Hcy and UA and hsCRP level in the three groups increased, and the difference of groups was statistically significant(P<0.01); Comparing any two groups, the Hcy and UA and hsCRP difference of grade 1 group and grade 2 group, and grade 1 group and grade 3 group were statistically significant(P<0.05). Using Pearson correlation analysis, we found that serum Hcy and UA and hsCRP were positively correlated with systolic blood pressure(r_1=0.573,r_2=0.706,r_3=0.711,P<0.01),and Hcy and hsCRP were positively correlated with diastolic blood pressure(r_4=0.421,r_5=0.566,P<0.01).[Conclusion]In young and middle-aged patients with hypertension, Hcy and UA and hs CRP are related to blood pressure level. Monitoring their level and trying to intervene these indicators provide ideas and basis for the prevention and treatment of hypertension.
[Objective]To explore the correlation between blood pressure level and homocysteine(Hcy), serum uric acid(UA) and hypersensitive C-reactive protein(hsCRP) in young and middle-aged patients with hypertension. [Methods]Sixty-eight young and middle-aged hypertension patients treated from August 2017 to November 2018 were selected. According to the blood pressure level, they were divided into hypertension grade 1 group(23 cases), hypertension grade 2 group(25 cases) and hypertension grade 3 group(20 cases). The general data of three groups were compared. Hcy and UA and hsCRP level of three groups were detected and compared, and the relationship between these and blood pressure level was analyzed.[Results]With the increasing of blood pressure grade, Hcy and UA and hsCRP level in the three groups increased, and the difference of groups was statistically significant(P<0.01); Comparing any two groups, the Hcy and UA and hsCRP difference of grade 1 group and grade 2 group, and grade 1 group and grade 3 group were statistically significant(P<0.05). Using Pearson correlation analysis, we found that serum Hcy and UA and hsCRP were positively correlated with systolic blood pressure(r_1=0.573,r_2=0.706,r_3=0.711,P<0.01),and Hcy and hsCRP were positively correlated with diastolic blood pressure(r_4=0.421,r_5=0.566,P<0.01).[Conclusion]In young and middle-aged patients with hypertension, Hcy and UA and hs CRP are related to blood pressure level. Monitoring their level and trying to intervene these indicators provide ideas and basis for the prevention and treatment of hypertension.
引文
[1] ROOZBEH J,SAGHEB M M,VAFAIE E.The association between blood pressure level and serum uric acid concentration in hemodialysis patients[J].Journal of Nephropathology,2015,4(3):85-90.
[2] 刘丹,敖卫,徐敏,等.H型高血压冠心病患者血清Hcy、β-2MG及hs-CRP检测的意义[J].中国循证心血管医学杂志,2016,8(6):687-690.
[3] MOZAFFARAN D,BENJAMIN E J,GO A S,et al.Heart disease and stroke statistics-2015 update:a report from the American Heart Association[J].Circulation,2015,131(4):299-322.
[4] LIBBY P.Changing concepts of atherogenesis[J].Journal of Internal Medicine,2000,247(3):349-358.
[5] 李倩,李东霞.高血压合并高同型半胱氨酸血症的研究进展[J].心血管病学进展,2018,39(2):187-190.
[6] MEURS J B,PARE G,SCHWARTZ S M,et al.Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease[J].American Journal of Clinical Nutrition,2013,98(3):668-676.
[7] 侯惠丽,陈瑛,吴萍,等.同型半胱氨酸水平对高血压前期患者进展为高血压的预测价值研究[J].中国全科医学,2018,21(22):2702-2706.
[8] 庄志成.血清同型半胱氨酸、内脂素与高血压分级的相关性[J].中国老年学杂志,2017,37(4):849-851.
[9] 杨琼.血清hs-CRP、Hcy水平与高血压危险分层的关联性及其临床意义[J].临床医学研究与实践,2018,3(30):92-93.
[10] 廖钦晨.血清同型半胱氨酸(Hcy)在高血压患者病情程度及诊断的作用分析[J].心血管病防治知识(学术版),2018,10(15):11-12.
[11] THOM T,HAASE N,ROSAMOND W.Heart disease and stroke statistics -2006 update:a report from the American heart association statistics committee and stroke statistics subcommitte[J].Circulation,2006,113(6):85-151.
[12] PADMA V,PRASAD A,ALAM K C ,et al.Serum uric acid in new and recent onset primary hypertension[J].Journal of Pharmacy and Bioallied Sciences,2015,7(5):4.-14.
[13] FORMAN J P,CHOI H,CURHAN G C.Uric Acid and Insulin Sensitivity and Risk of Incident Hypertension[J].Archives of Internal Medicine,2009,169(2):155.
[14] 李国裕,李文朗,谢治华.外周血及尿液检测指标与女性高血压前期及高血压的相关性研究[J].检验医学与临床,2016,13(20):2904-2906.
[15] JOHNSON W D,KAYSER K L,BRENOWITZ J B ,et al.A randomized controlled trial of allopurinol in coronary bypass surgery.[J].American Heart Journal,1991,15(2):202-204.
[16] 邝健,麦炜颐,黄裕立,等.别嘌醇治疗中青年高血压病合并高尿酸血症[J].中山大学学报(医学科学版),2009,30(6):762-766.
[17] 祁泽明,张晓燕,丁丰熙,等.原发性高血压患者血压分级与血尿酸、胆红素和hs-CRP水平的关系[J].临床心血管病杂志,2012,28(3):234-235.
[18] 唐玉宏.原发性高血压患者血浆hsCRP、Hcy水平与血压变异性的相关性[J].心血管康复医学杂志,2018,27(1):5-9.
[2] 刘丹,敖卫,徐敏,等.H型高血压冠心病患者血清Hcy、β-2MG及hs-CRP检测的意义[J].中国循证心血管医学杂志,2016,8(6):687-690.
[3] MOZAFFARAN D,BENJAMIN E J,GO A S,et al.Heart disease and stroke statistics-2015 update:a report from the American Heart Association[J].Circulation,2015,131(4):299-322.
[4] LIBBY P.Changing concepts of atherogenesis[J].Journal of Internal Medicine,2000,247(3):349-358.
[5] 李倩,李东霞.高血压合并高同型半胱氨酸血症的研究进展[J].心血管病学进展,2018,39(2):187-190.
[6] MEURS J B,PARE G,SCHWARTZ S M,et al.Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease[J].American Journal of Clinical Nutrition,2013,98(3):668-676.
[7] 侯惠丽,陈瑛,吴萍,等.同型半胱氨酸水平对高血压前期患者进展为高血压的预测价值研究[J].中国全科医学,2018,21(22):2702-2706.
[8] 庄志成.血清同型半胱氨酸、内脂素与高血压分级的相关性[J].中国老年学杂志,2017,37(4):849-851.
[9] 杨琼.血清hs-CRP、Hcy水平与高血压危险分层的关联性及其临床意义[J].临床医学研究与实践,2018,3(30):92-93.
[10] 廖钦晨.血清同型半胱氨酸(Hcy)在高血压患者病情程度及诊断的作用分析[J].心血管病防治知识(学术版),2018,10(15):11-12.
[11] THOM T,HAASE N,ROSAMOND W.Heart disease and stroke statistics -2006 update:a report from the American heart association statistics committee and stroke statistics subcommitte[J].Circulation,2006,113(6):85-151.
[12] PADMA V,PRASAD A,ALAM K C ,et al.Serum uric acid in new and recent onset primary hypertension[J].Journal of Pharmacy and Bioallied Sciences,2015,7(5):4.-14.
[13] FORMAN J P,CHOI H,CURHAN G C.Uric Acid and Insulin Sensitivity and Risk of Incident Hypertension[J].Archives of Internal Medicine,2009,169(2):155.
[14] 李国裕,李文朗,谢治华.外周血及尿液检测指标与女性高血压前期及高血压的相关性研究[J].检验医学与临床,2016,13(20):2904-2906.
[15] JOHNSON W D,KAYSER K L,BRENOWITZ J B ,et al.A randomized controlled trial of allopurinol in coronary bypass surgery.[J].American Heart Journal,1991,15(2):202-204.
[16] 邝健,麦炜颐,黄裕立,等.别嘌醇治疗中青年高血压病合并高尿酸血症[J].中山大学学报(医学科学版),2009,30(6):762-766.
[17] 祁泽明,张晓燕,丁丰熙,等.原发性高血压患者血压分级与血尿酸、胆红素和hs-CRP水平的关系[J].临床心血管病杂志,2012,28(3):234-235.
[18] 唐玉宏.原发性高血压患者血浆hsCRP、Hcy水平与血压变异性的相关性[J].心血管康复医学杂志,2018,27(1):5-9.