血浆髓过氧化物酶水平与冠状动脉狭窄程度的相关性分析
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摘要
目的探究血浆髓过氧化物酶(myeloperoxidase,MPO)水平与冠状动脉狭窄程度的相关性。方法选取2013年7月至2015年12月在云南省楚雄彝族自治州人民医院心内科住院接受冠状动脉造影(coronary angiogram,CAG)的710例患者作为研究对象,分为冠状动脉综合症(arteria coronaria,ACS)组,稳定型心绞痛(stable Angina,SAP)组,冠状动脉造影结果正常人员作为对照组,观察血浆髄过氧化物酶水平与冠状动脉狭窄程度相关性。结果三组入选对象在高血压患者所占比重、血糖水平、尿素氮、肌酐等指标上进行对比差异均无统计学意义(P> 0. 05); ACS组与其他两组MPO水平对比差异较为明显,具有统计学意义(P<0.05);SAP与对照组在MPO水平上进行对比,差异无统计学意义(P>0.05);无狭窄者MPO水平为14.25±3.26μg/L,明显低于其他组患者,差异具有统计学意义(P <0.05);重度狭窄患者MPO水平为41.58±10. 64μg/L,明显高于其他组患者,差异具有统计学意义(P <0.05);血浆MPO水平与冠状动脉狭窄程度呈正相关关系(r=0.534,P=0.235)。结论冠状动脉狭窄程度越高则相应的血浆MPO水平越高,可将血浆髓过氧化物酶作为冠状动脉病变的辅助诊断指标。
Objective To investigate the relationship between plasma myeloperoxidase(MPO) and coronary artery stenosis. Methods From July,2013 to December,2015,710 patients who received coronary angiography(coronary angiogram, CAG) in Department of Cardiology, Chuxiong Yi Autonomous Hospital, Yunnan Province, were divided into the coronary artery syndrome(arteria coronaria, ACS) group and the stable angina pectoris(Stable Angina,SAP) group. The plasma myeloperoxidase level and the degree of coronary artery stenosis were observed in both groups,as well in selected normal subjects as the control group. Results We selected portions of patients based on parameters,including hypertension,blood sugar level and urea in the three groups. There were no significant differences in nitrogen,creatinine and other indexes(all P >0.05).There was significant difference in MPO level between the ACS group and the other two groups(P <0.05),but no difference between the SAP group and the control group(P >0. 05). The level of MPO in patients without stenosis was 14. 25 ±3. 26μg/L,which was significantly lower than that other groups(P <0.05),and the level of MPO in patients with severe stenosis was 41.58 ± 10.64μg/L,which was significantly lower than that in other groups(P < 0. 05). The plasma MPO concentration was positively correlated with the degree of coronary artery stenosis. Conclusion The higher the degrees of coronary artery stenosis are, the higher the corresponding plasma MPO levels are, which could serve as an diagnostic marker for coronary artery stenosis.
Objective To investigate the relationship between plasma myeloperoxidase(MPO) and coronary artery stenosis. Methods From July,2013 to December,2015,710 patients who received coronary angiography(coronary angiogram, CAG) in Department of Cardiology, Chuxiong Yi Autonomous Hospital, Yunnan Province, were divided into the coronary artery syndrome(arteria coronaria, ACS) group and the stable angina pectoris(Stable Angina,SAP) group. The plasma myeloperoxidase level and the degree of coronary artery stenosis were observed in both groups,as well in selected normal subjects as the control group. Results We selected portions of patients based on parameters,including hypertension,blood sugar level and urea in the three groups. There were no significant differences in nitrogen,creatinine and other indexes(all P >0.05).There was significant difference in MPO level between the ACS group and the other two groups(P <0.05),but no difference between the SAP group and the control group(P >0. 05). The level of MPO in patients without stenosis was 14. 25 ±3. 26μg/L,which was significantly lower than that other groups(P <0.05),and the level of MPO in patients with severe stenosis was 41.58 ± 10.64μg/L,which was significantly lower than that in other groups(P < 0. 05). The plasma MPO concentration was positively correlated with the degree of coronary artery stenosis. Conclusion The higher the degrees of coronary artery stenosis are, the higher the corresponding plasma MPO levels are, which could serve as an diagnostic marker for coronary artery stenosis.
引文
[1]程敏菊,程敏静,魏庆民,等. MPO联合Hey评估急性冠脉综合征患者病变程度的临床价值[J].中国地方病防治杂志,2017,32(8):904-905.
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[6]乔雁翔,陈巍,卢星文,等.急性冠状动脉综合征患者血浆髄过氧化物酶水平与病变程度的相关性[J].贵阳医学院学报,2013,38(4):382-384.
[7]李静,张瑞,尉俊生,等.冠心病患者PCI手术前后血清髓过氧化物酶水平变化及临床意义[J].疑难病杂志,2015,14(7):664-667.
[8]振宇李,猛杨,传昶李,等.稳定性心绞痛患者血浆髓过氧化物酶水平与冠脉病变严重程度及侧枝循环的关系研究[J].临床与病理杂志,2014,34(1):66.
[2]吴娜琼,李莎,郭远林,等.血浆PCSK9水平与冠状动脉狭窄程度的相关性研究[J].临床心血管病杂志,2016,32(3):260-264.
[3] JOO H J, CHO S A, CHO J Y, et al. The relationship between pulse wave velocity and coronary artery stenosis and percutaneous coronary intervention:a retrospective observational study[J]. BMC Cardiovasc Disord,2017,17(1):45.
[4]胡玉英,刘泰,胡跃强,等.中青年颈动脉粥样硬化斑块形成患者中医证型与血浆髓过氧化物酶、颈动脉斑块类型的关系[J].重庆医学,2014,43(1):33-34.
[5]凌娟,向羿,易军,等.血浆髓过氧化物酶水平与冠状动脉病变严重程度及侧支循环的关系[J].临床与病理杂志,2014,34(3):238-243.
[6]乔雁翔,陈巍,卢星文,等.急性冠状动脉综合征患者血浆髄过氧化物酶水平与病变程度的相关性[J].贵阳医学院学报,2013,38(4):382-384.
[7]李静,张瑞,尉俊生,等.冠心病患者PCI手术前后血清髓过氧化物酶水平变化及临床意义[J].疑难病杂志,2015,14(7):664-667.
[8]振宇李,猛杨,传昶李,等.稳定性心绞痛患者血浆髓过氧化物酶水平与冠脉病变严重程度及侧枝循环的关系研究[J].临床与病理杂志,2014,34(1):66.