miRNAs在肝细胞癌中的研究进展
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摘要
肝细胞癌(HCC)是最常见的恶性肿瘤,死亡率居高不下,严重影响人类健康。由于其病因复杂,诊断治疗方法有限,给患者及医师带来很大困惑。miRNAs的发现为HCC预后和治疗中的作用进行综述。
Hepatocellular carcinoma(HCC)is the most common malignant tumor,and the mortality rate remains high,which seriously affects human health. Due to its complicated etiology,the diagnosis and treatment methods are limited,which brings great confusion to patients and physicians. The discovery of miRNAs has helped diagnose,treat,and prognose HCC. This article reviews the role of miRNAs in the diagnosis,prognosis and treatment of HCC.
Hepatocellular carcinoma(HCC)is the most common malignant tumor,and the mortality rate remains high,which seriously affects human health. Due to its complicated etiology,the diagnosis and treatment methods are limited,which brings great confusion to patients and physicians. The discovery of miRNAs has helped diagnose,treat,and prognose HCC. This article reviews the role of miRNAs in the diagnosis,prognosis and treatment of HCC.
引文
[1]Liu D,Liu A,Peng J,et al.Case analysis of complete remission of advanced hepatocellular carcinoma achieved with sorafenib[J].Eur J Med Res,2015,20(1):1-6.
[2]Wilson CL,Mann DA,Borthwick LA.Epigenetic reprogramming in liver fibrosis and cancer[J].Adv Drug Deliv Rev,2017,1(121):124-132.
[3]Song Y,Wang F,Huang Q,et al.MicroRNAs Contribute to Hepatocellular Carcinoma[J].Mini Rev Med Chem,2015,15(6):459-466.
[4]Ji J,Shi J,Budhu A,et al.MicroRNA expression,survival,and response to interferon in liver cancer[J].N Engl J Med,2009,361(15):1437-1447.
[5]Wei R,Huang GL,Zhang MY,et al.Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma[J].Clin Cancer Res,2013,19(17):4780-4791.
[6]Jiang J,Gusev Y,Aderca I,et al.Association of microRNA expression in hepatocellular carcinomas with hepatitis infection,cirrhosis,and patient survival[J].Clin Cancer Res,2008,14(2):419-427.
[7]史炯.循环miRNA在肝癌诊断及预后预测中的研究进展[J].中国肿瘤临床,2011,38(17):1048-1051.
[8]Ghosh A,Ghosh A,Datta S,et al..Hepatic miR-126 is a potential plasma biomarker for detection of hepatitis B virus infected hepatocellular carcinoma[J].Int J Cancer,2016,138(11):2732-2744.
[9]Liu AM,Yao T,Wang W,et al.Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma:a retrospective cohort study[J].BMJ Open,2012,2(2):1-10.
[10]Thakral S,Ghoshal K.miR-122 is a unique molecule with great potential in diagnosis,prognosis of liver disease,and therapy both as miRNA mimic and antimir[J].Curr Gene Ther,2015,15(2):142-150.
[11]Pomakov A,Toshkov I,Buitrago S,et al.Developing anti-angiogenic therapies for human hepatocellular cancer(HCC)-studies of suntinib in the woodchuck model of hepatitis B related HCC[J].Cancer Res,2014,74(19):4946.
[12]Laudadio I,Manfroid I,Achouri Y,et al.A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation[J].Gastroenterology,2012,142(1):119-129.
[13]Yahya SMM,Fathy SA,El-Khayat ZA,et al,Possible Role of microRNA-122 in Modulating Multidrug Resistance of Hepatocellular Carcinoma[J].Indian J Clin Biochem,2018,33(1):21-30.
[14]Gramantieri L,Ferracin M,Fornari F,et al.Cyclin G1 is a target of miR-122a,a microRNA frequently down-regulated in human hepatocellular carcinoma[J].Cancer Res,2007,67(1):6092-6099.
[15]Fiorino S,Bacchi-Reggiani ML,Visani M,et al.MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B-and C-related-hepatocellular carcinoma[J].World J Gastroenterol,2016,22(15):3907-3936.
[16]Girard M,Jacquemin E,Munnich A.miR-122,a paradigm for the role of microRNAs in the liver[J].J Hepatol,2008,48(4):648-656.
[17]Jiang J,Gusev Y,Aderca I,et al.Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection,cirrhosis,and patient survival[J].Clin Cancer Res,2008,14(1):419-427.
[18]Braconi C,Henry JC,Kogure T,et al.The Role of MicroRNAs in Human Liver Cancers[J].Semin Oncol,2011,38(6):752-763.
[19]Morgan TR,Mandayam S,Jamal MM.Alcohol and hepatocellular carcinoma[J].Gastroenterology,2004,127(1):87-96.
[20]Kim S,Lee UJ,Kim MN,et al.MicroRNA miR-199a*regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2(ERK2)[J].J Biol Chem,2008,283(26):18158-18166.
[21]Fornari F,Milazzo M,Chieco P,et al.MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells[J].Cancer Res,2010,70(12):5184-5193.
[22]Okajima W,Komatsu S,Ichikawa D,et al.Circulating microR-NA profiles in plasma:identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function[J].Oncotarget,2016,7(33):53820-53836.
[23]Scisciani C,Vossio S,Guerrieri F,et al.Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways[J].J Hepatol,2012,56(4):855-861.
[24]Yang Z,Zhang Y,Wang L.A feedback inhibition between miR-NA-127 and TGFβ/c-Jun cascade in HCC cell migration via MMP13[J].PLoS One,2013,8(6):1-9.
[25]Tryndyak VP,Ross SA,Beland FA,et al.Down-regulation of the microRNAs miR-34a,miR-127,and miR-200b in rat liver during hepatocar-cinogenesis induced by a methyl-deficient diet[J].Mol Carcinog,2009,48(3):479-487.
[26]Gailhouste L,Gomez-Santos L,Hagiwara K,et al.miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells[J].Hepatology,2013,58(3):1153-1165.
[27]Yuan K,Lian Z,Sun B,et al.Role of miR-148a in Hepatitis BAssociated Hepatocellular Carcinoma[J].PLoS One,2012,7(4):1-12.
[28]Cheng L,Zhu Y,Han H,et al.MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice[J].Cell Death Dis,2017,8(7):1-6.
[29]Bandiera S,Pfeffer S,Baumert TF,et al.miR-122--a key factor and therapeutic target in liver disease[J].J Hepatol,2015,62(2):448-457.
[30]Zhang H,Sun Z,Yu L,et al.MiR-139-5p inhibits proliferation and promoted apoptosis of human airway smooth muscle cells by downregulating the Brg1 gene[J].Respir Physiol Neurobiol,2017,246(1):9-16.
[31]Wang F,Ying H,He B,et al.Circulating miR-148/152 family as potential biomarkers in hepatocellular carcinoma[J].Tumour Biol,2016,37(4):4945-4953.
[32]Zhang Y,Wei C,Guo CC,Bi RX,et al.Prognostic value of microRNAs in hepatocellular carcinoma:a meta-analysis[J].Oncotarget,2017,8(63):107237-107257
[33]Pan L,Huang S,He R,et al.Decreased expression and clinical significance of miR-148a in hepatocellular carcinoma tissues[J].Eur J Med Res,2014,19(1):68-73.
[34]Tang Y,Cui Y,Li Z,et al.Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells[J].J Exp Clin Cancer Res,2016,35(1):7-21.
[35]Pan JH,Zhou H,Zhao XX,et al.Role of exosomes and exosomal microRNAs in hepatocellular carcinoma:Potential in diagnosis and antitumour treatments(Review)[J].Int J Mol Med,2018,41(4):1809-1816.
[36]Yang S,Liu W,Li M,et al.Insulin-Like Growth Factor-1 Modulates Polycomb Cbx8 Expression and Inhibits Colon Cancer Cell Apoptosis[J].Cell Biochem Biophys,2015,71(3):1503-1507.
[37]Sugimachi K,Matsumura T,Hirata H,et al.Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation[J].Br J Cancer,2015,112(3):532-538.
[38]Xie KL,Zhang YG,Liu J,et al.MicroRNAs associated with HBV infection and HBV-related HCC[J].Theranostics,2014,4(12):1176-1192.
[39]项灯,程灏.MicroRNA-21的表达调控在器官纤维化中的作用[J].医学研究生学报,2017,30(12):1326-1331.
[40]施慧,王震凯,汪芳裕,等.早期胃癌的多学科联合诊治[J].医学研究生学报,2016,29(5):529-532.
[41]郭固楠,陈筠,熊彬,等.RNA干扰GCF2基因沉默对人肝癌BEL-7404细胞周期的影响[J].医学研究生学报,2017,30(3):262-265.
[2]Wilson CL,Mann DA,Borthwick LA.Epigenetic reprogramming in liver fibrosis and cancer[J].Adv Drug Deliv Rev,2017,1(121):124-132.
[3]Song Y,Wang F,Huang Q,et al.MicroRNAs Contribute to Hepatocellular Carcinoma[J].Mini Rev Med Chem,2015,15(6):459-466.
[4]Ji J,Shi J,Budhu A,et al.MicroRNA expression,survival,and response to interferon in liver cancer[J].N Engl J Med,2009,361(15):1437-1447.
[5]Wei R,Huang GL,Zhang MY,et al.Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma[J].Clin Cancer Res,2013,19(17):4780-4791.
[6]Jiang J,Gusev Y,Aderca I,et al.Association of microRNA expression in hepatocellular carcinomas with hepatitis infection,cirrhosis,and patient survival[J].Clin Cancer Res,2008,14(2):419-427.
[7]史炯.循环miRNA在肝癌诊断及预后预测中的研究进展[J].中国肿瘤临床,2011,38(17):1048-1051.
[8]Ghosh A,Ghosh A,Datta S,et al..Hepatic miR-126 is a potential plasma biomarker for detection of hepatitis B virus infected hepatocellular carcinoma[J].Int J Cancer,2016,138(11):2732-2744.
[9]Liu AM,Yao T,Wang W,et al.Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma:a retrospective cohort study[J].BMJ Open,2012,2(2):1-10.
[10]Thakral S,Ghoshal K.miR-122 is a unique molecule with great potential in diagnosis,prognosis of liver disease,and therapy both as miRNA mimic and antimir[J].Curr Gene Ther,2015,15(2):142-150.
[11]Pomakov A,Toshkov I,Buitrago S,et al.Developing anti-angiogenic therapies for human hepatocellular cancer(HCC)-studies of suntinib in the woodchuck model of hepatitis B related HCC[J].Cancer Res,2014,74(19):4946.
[12]Laudadio I,Manfroid I,Achouri Y,et al.A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation[J].Gastroenterology,2012,142(1):119-129.
[13]Yahya SMM,Fathy SA,El-Khayat ZA,et al,Possible Role of microRNA-122 in Modulating Multidrug Resistance of Hepatocellular Carcinoma[J].Indian J Clin Biochem,2018,33(1):21-30.
[14]Gramantieri L,Ferracin M,Fornari F,et al.Cyclin G1 is a target of miR-122a,a microRNA frequently down-regulated in human hepatocellular carcinoma[J].Cancer Res,2007,67(1):6092-6099.
[15]Fiorino S,Bacchi-Reggiani ML,Visani M,et al.MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B-and C-related-hepatocellular carcinoma[J].World J Gastroenterol,2016,22(15):3907-3936.
[16]Girard M,Jacquemin E,Munnich A.miR-122,a paradigm for the role of microRNAs in the liver[J].J Hepatol,2008,48(4):648-656.
[17]Jiang J,Gusev Y,Aderca I,et al.Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection,cirrhosis,and patient survival[J].Clin Cancer Res,2008,14(1):419-427.
[18]Braconi C,Henry JC,Kogure T,et al.The Role of MicroRNAs in Human Liver Cancers[J].Semin Oncol,2011,38(6):752-763.
[19]Morgan TR,Mandayam S,Jamal MM.Alcohol and hepatocellular carcinoma[J].Gastroenterology,2004,127(1):87-96.
[20]Kim S,Lee UJ,Kim MN,et al.MicroRNA miR-199a*regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2(ERK2)[J].J Biol Chem,2008,283(26):18158-18166.
[21]Fornari F,Milazzo M,Chieco P,et al.MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells[J].Cancer Res,2010,70(12):5184-5193.
[22]Okajima W,Komatsu S,Ichikawa D,et al.Circulating microR-NA profiles in plasma:identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function[J].Oncotarget,2016,7(33):53820-53836.
[23]Scisciani C,Vossio S,Guerrieri F,et al.Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways[J].J Hepatol,2012,56(4):855-861.
[24]Yang Z,Zhang Y,Wang L.A feedback inhibition between miR-NA-127 and TGFβ/c-Jun cascade in HCC cell migration via MMP13[J].PLoS One,2013,8(6):1-9.
[25]Tryndyak VP,Ross SA,Beland FA,et al.Down-regulation of the microRNAs miR-34a,miR-127,and miR-200b in rat liver during hepatocar-cinogenesis induced by a methyl-deficient diet[J].Mol Carcinog,2009,48(3):479-487.
[26]Gailhouste L,Gomez-Santos L,Hagiwara K,et al.miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells[J].Hepatology,2013,58(3):1153-1165.
[27]Yuan K,Lian Z,Sun B,et al.Role of miR-148a in Hepatitis BAssociated Hepatocellular Carcinoma[J].PLoS One,2012,7(4):1-12.
[28]Cheng L,Zhu Y,Han H,et al.MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice[J].Cell Death Dis,2017,8(7):1-6.
[29]Bandiera S,Pfeffer S,Baumert TF,et al.miR-122--a key factor and therapeutic target in liver disease[J].J Hepatol,2015,62(2):448-457.
[30]Zhang H,Sun Z,Yu L,et al.MiR-139-5p inhibits proliferation and promoted apoptosis of human airway smooth muscle cells by downregulating the Brg1 gene[J].Respir Physiol Neurobiol,2017,246(1):9-16.
[31]Wang F,Ying H,He B,et al.Circulating miR-148/152 family as potential biomarkers in hepatocellular carcinoma[J].Tumour Biol,2016,37(4):4945-4953.
[32]Zhang Y,Wei C,Guo CC,Bi RX,et al.Prognostic value of microRNAs in hepatocellular carcinoma:a meta-analysis[J].Oncotarget,2017,8(63):107237-107257
[33]Pan L,Huang S,He R,et al.Decreased expression and clinical significance of miR-148a in hepatocellular carcinoma tissues[J].Eur J Med Res,2014,19(1):68-73.
[34]Tang Y,Cui Y,Li Z,et al.Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells[J].J Exp Clin Cancer Res,2016,35(1):7-21.
[35]Pan JH,Zhou H,Zhao XX,et al.Role of exosomes and exosomal microRNAs in hepatocellular carcinoma:Potential in diagnosis and antitumour treatments(Review)[J].Int J Mol Med,2018,41(4):1809-1816.
[36]Yang S,Liu W,Li M,et al.Insulin-Like Growth Factor-1 Modulates Polycomb Cbx8 Expression and Inhibits Colon Cancer Cell Apoptosis[J].Cell Biochem Biophys,2015,71(3):1503-1507.
[37]Sugimachi K,Matsumura T,Hirata H,et al.Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation[J].Br J Cancer,2015,112(3):532-538.
[38]Xie KL,Zhang YG,Liu J,et al.MicroRNAs associated with HBV infection and HBV-related HCC[J].Theranostics,2014,4(12):1176-1192.
[39]项灯,程灏.MicroRNA-21的表达调控在器官纤维化中的作用[J].医学研究生学报,2017,30(12):1326-1331.
[40]施慧,王震凯,汪芳裕,等.早期胃癌的多学科联合诊治[J].医学研究生学报,2016,29(5):529-532.
[41]郭固楠,陈筠,熊彬,等.RNA干扰GCF2基因沉默对人肝癌BEL-7404细胞周期的影响[J].医学研究生学报,2017,30(3):262-265.