(4,4’-二苯醚二甲酸)(诺氟沙星)Cu(Ⅱ)配合物的结构及抑菌活性
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摘要
采用水热法合成了诺氟沙星金属配合物[Cu(C16H18N3FO3)2(C14H8O5)(H2O)3],并应用X-射线单晶衍射技术对其结构进行测定,确定了其几何构型,探讨了金属离子与药物分子的配位方式.采用琼脂扩散法对比4种常见细菌对药物的敏感性,结果表明合成的金属配合物具有一定的抑菌作用.
The metal complex of norfloxacin was synthesized by hydrothermal method,and the synthesis conditions were optimized.The metal complex[Cu(C16 H18 N3 FO3)2(C14 H8 O5)(H2 O)3]was synthesized.The structure of the metal complex was determined by X-ray single crystal diffraction.The geometric configuration of the complex was determined.Agar diffusion method was used to compare the sensitivity of four common bacteria to drugs.The synthesized metal complexes has certain bacteriostatic effect.
The metal complex of norfloxacin was synthesized by hydrothermal method,and the synthesis conditions were optimized.The metal complex[Cu(C16 H18 N3 FO3)2(C14 H8 O5)(H2 O)3]was synthesized.The structure of the metal complex was determined by X-ray single crystal diffraction.The geometric configuration of the complex was determined.Agar diffusion method was used to compare the sensitivity of four common bacteria to drugs.The synthesized metal complexes has certain bacteriostatic effect.
引文
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[2] BALL P.[J].J Antimicrob Chemother,2000,46:17-24.
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[5] GAO F,YANG P,XIE J,et al.[J].J Inorg Bio-chem,1995,60:61-67.
[6] EFTHIMIADOU E K,PSOMAS G,SANAKIS Y,et al.[J].J Inorg Biochem,2007,101:525-535.
[7]倪语星,尚红.临床微生物学检验[M].第5版.北京:人民卫生出版社,2012:58.
[8]邵莉萍,张继瑜.[J].中国畜牧兽医,2017,44(9):2773-2782.
[9]贺全山,杨昌云,陈维中,等.[J].药学实践杂志,2007(5):303-306.
[10]王锡森,宋玉梅,熊仁根.[J].无机化学学报,2005,21(8):1270-1274.
[11]王国平.喹诺酮金属配合物的合成、结构与生物活性[D].杭州:浙江大学,2002.
[12]陈威,雷群芳,王国平.[J].浙江大学学报(理学版),2008(5):533-556.
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[14]钟文英,黄琦,王丹丹,等.[J].药学学报,2005(7):663-667.
[15]林赴田,刘尚俗,宋坤改,等.[J].国外医药(抗生素分册),2005(4):166-169.