miR-214与肿瘤的关系研究进展
摘要
微小RNA(microRNA,miRNA)是一类22～24nt的非编码小分子RNA,可通过miRNA的种子序列(5’端的核苷酸2-8)与其互补的种子匹配序列(存在于目标mRNA的3’端非翻译区中)之间的规范碱基配对来调节基因的表达。通过特异性的靶向相应的功能性癌基因,miRNA在肿瘤的发生发展过程中起到促进或抑制肿瘤细胞增殖、侵袭、转移等生物学功能。miR-214作为miRNA家族中的重要一员,在结直肠癌、胃癌、乳腺癌、肝癌、肺癌、胰腺癌、卵巢癌、宫颈癌等肿瘤中起到促癌或抑癌的作用。本文就miR-214在不同肿瘤中的生理作用及相应靶点的研究现状作一综述。
引文
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[10]Bar-Eli M.Searching for the'melano-miRs':miR-214 drives melanoma metastasis[J].EMBO J,2011,30(10):1880-1881.
[11]Baumgartner U,Berger F,Hashemi Gheinani A,et al.miR-19b enhances proliferation and apoptosis resistance via the EGFRsignaling pathway by targeting PP2A and BIM in non-small cell lung cancer[J].Mol Cancer,2018,17(1):44.
[12]Huang G,Nishimoto K,Zhou Z,et al.miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression[J].Cancer Res,2012,72(4):908-916.
[13]Lin HY,Chiang CH,Hung WC.STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells[J].Br J Cancer,2013,109(3):731-738.
[14]Zaravinos A.The regulatory role of microRNAs in EMT and cancer[J].J Oncol,2015,2015:865816.
[15]Zhu S,Wu H,Wu F,et al.MicroRNA-21 targets tumor suppressor genes in invasion and metastasis[J].Cell Res,2008,18(3):350-359.
[16]Cai J,Fang L,Huang Y,et al.miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in nonsmall cell lung cancer[J].Cancer Res,2013,73(17):5402-5415.
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[18]Xiao C,Calado DP,Galler G,et al.MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb[J].Cell,2007,131(1):146-159.
[19]Huang Q,Gumireddy K,Schrier M,et al.The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis[J].Nat Cell Biol,2008,10(2):202-210.
[20]No authors listed.The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60,HSP70 and caspase-9 in cardiomyocytes[J].J Cell Sci,2011,124(Pt 18):3187.
[21]Cheng AM,Byrom MW,Shelton J,et al.Antisense inhibition of human miRNA and indications for an involvement of miRNA in cell growth and apoptosis[J].Nucleic Acids Res,2005,33(4):1290-1297.
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[26]Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
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[28]Phatak P,Byrnes KA,Mansour D,et al.Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1[J].Oncogene,2016,35(16):2087-2097.
[29]Xu Y,Lu S.Regulation of beta-catenin-mediated esophageal cancer growth and invasion by miR-214[J].Am J Transl Res,2015,7(11):2316-2325.
[30]Herbst RS,Morgensztern D,Boshoff C.The biology and management of non-small cell lung cancer[J].Nature,2018,553(7689):446-454.
[31]Hirsch FR,Scagliotti GV,Mulshine JL,et al.Lung cancer:current therapies and new targeted treatments[J].Lancet,2017,389(10066):299-311.
[32]Zhang K,Zhang M,Jiang H,et al.Down-regulation of miR-214inhibits proliferation and glycolysis in non-small-cell lung cancer cells via down-regulating the expression of hexokinase 2 and pyruvate kinase isozyme M2[J].Biomed Pharmacother,2018,105:545-552.
[33]Liao J,Lin J,Lin D,et al.Down-regulation of miR-214 reverses erlotinib resistance in non-small-cell lung cancer through upregulating LHX6 expression[J].Sci Rep,2017,7(1):781.
[34]Fan L,Strasser-Weippl K,Li JJ,et al.Breast cancer in China[J].Lancet Oncol,2014,15(7):e279-e289.
[35]Orso F,Quirico L,Virga F,et al.miR-214 and miR-148b targeting inhibits dissemination of melanoma and breast cancer[J].Cancer Res,2016,76(17):5151-5162.
[36]Yi SJ,Li LL,Tu WB.MiR-214 negatively regulates proliferation and WNT/beta-catenin signaling in breast cancer[J].Eur Rev Med Pharmacol Sci,2016,20(24):5148-5154.
[37]Derfoul A,Juan AH,Difilippantonio MJ,et al.Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation,invasion and accumulation of the Polycomb Ezh2 methyltransferase[J].Carcinogenesis,2011,32(11):1607-1614.
[38]Yu X,Luo A,Liu Y,et al.MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy[J].Mol Cancer,2015,14:208.
[39]Hu JL,He GY,Lan XL,et al.Inhibition of ATG12-mediated autophagy by miR-214 enhances radiosensitivity in colorectal cancer[J].Oncogenesis,2018,7(2):16.
[40]Chen D L,Wang ZQ,Zeng ZL,et al.Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor1 expression[J].Hepatology,2014,60(2):598-609.
[41]Chandrasekaran KS,Sathyanarayanan A,Karunagaran D.Micro RNA-214 suppresses growth,migration and invasion through a novel target,high mobility group AT-hook 1,in human cervical and colorectal cancer cells[J].Br J Cancer,2016,115(6):741-751.
[42]He GY,Hu JL,Zhou L,et al.The FOXD3/miR-214/MED19 axis suppresses tumour growth and metastasis in human colorectal cancer[J].Br J Cancer,2016,115(11):1367-1378.
[43]Alexandrov LB,Nik-Zainal S,Wedge DC,et al.Signatures of mutational processes in human cancer[J].Nature,2013,500(7463):415-421.
[44]Yang H,Kong W,He L,et al.MicroRNA expression profiling in human ovarian cancer:miR-214 induces cell survival and cisplatin resistance by targeting PTEN[J].Cancer Res,2008,68(2):425-433.
[45]Yin G,Chen R,Alvero AB,et al.TWISTing stemness,inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214[J].Oncogene,2010,29(24):3545-3553.
[46]Shih TC,Tien YJ,Wen CJ,et al.MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma[J].J Hepatol,2012,57(3):584-591.
[47]Wang J,Li J,Wang X,et al.Downregulation of microRNA-214and overexpression of FGFR-1 contribute to hepatocellular carcinoma metastasis[J].Biochem Biophys Res Commun,2013,439(1):47-53.
[48]Wang X,Chen J,Li F,et al.MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of beta-catenin[J].Biochem Biophys Res Commun,2012,428(4):525-531.
[49]Wang F,Liu M,Li X,et al.MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2L2 in cervical cancer cells[J].FEBS Lett,2013,587(5):488-495.
[50]Dettori D,Orso F,Penna E,et al.Therapeutic silencing of miR-214inhibits tumor progression in multiple mouse models[J].Mol Ther,2018,26(8):2008-2018.
[51]Andersson R,Aho U,Nilsson B I,et al.Gemcitabine chemoresistance in pancreatic cancer:molecular mechanisms and potential solutions[J].Scand J Gastroenterol,2009,44(7):782-786.
[52]Zhang XJ,Ye H,Zeng CW,et al.Dysregulation of miR-15a and miR-214 in human pancreatic cancer[J].J Hematol Oncol,2010,3:46.
[53]Xu C,He T,Li Z,et al.Regulation of HOXA11-AS/miR-214-3p/EZH2 axis on the growth,migration and invasion of glioma cells[J].Biomed Pharmacother,2017,95:1504-1513.
[54]Wang J,Zhang X,Wang L,et al.MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1in bladder cancer[J].PLoS One,2015,10(2):e0118086.
[55]Yang L,Zhang W,Wang Y,et al.Hypoxia-induced miR-214expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells[J].Cancer Lett,2018,414:44-56.
[56]Yang TS,Yang XH,Wang XD,et al.MiR-214 regulate gastric cancer cell proliferation,migration and invasion by targeting PTEN[J].Cancer Cell Int,2013,13(1):68.
[57]Yin Y,Cai X,Chen X,et al.Tumor-secreted miR-214 induces regulatory T cells:a major link between immune evasion and tumor growth[J].Cell Res,2014,24(10):1164-1180.
[2]Lin S,Gregory RI.MicroRNA biogenesis pathways in cancer[J].Nat Rev Cancer,2015,15(6):321-333.
[3]Griffiths-Jones S,Grocock RJ,Van Dongen S,et al.miRBase:microRNA sequences,targets and gene nomenclature[J].Nucleic Acids Res,2006,34(Database issue):D140-D144.
[4]Griffiths-Jones S.The microRNA Registry[J].Nucleic Acids Res,2004,32(Database issue):D109-D111.
[5]Ceppi P,Peter ME.MicroRNAs regulate both epithelial-tomesenchymal transition and cancer stem cells[J].Oncogene,2014,33(3):269-278.
[6]Di Leva G,Garofalo M,Croce CM.MicroRNAs in cancer[J].Annu Rev Pathol,2014,9:287-314.
[7]Feng B,Zhang K,Wang R,et al.Non-small-cell lung cancer and miRNA:novel biomarkers and promising tools for treatment[J].Clin Sci(Lond),2015,128(10):619-634.
[8]Friedman RC,Farh KK,Burge CB,et al.Most mammalian mRNAs are conserved targets of microRNAs[J].Genome Res,2009,19(1):92-105.
[9]Hayes J,Peruzzi PP,Lawler S.MicroRNAs in cancer:biomarkers,functions and therapy[J].Trends Mol Med,2014,20(8):460-469.
[10]Bar-Eli M.Searching for the'melano-miRs':miR-214 drives melanoma metastasis[J].EMBO J,2011,30(10):1880-1881.
[11]Baumgartner U,Berger F,Hashemi Gheinani A,et al.miR-19b enhances proliferation and apoptosis resistance via the EGFRsignaling pathway by targeting PP2A and BIM in non-small cell lung cancer[J].Mol Cancer,2018,17(1):44.
[12]Huang G,Nishimoto K,Zhou Z,et al.miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression[J].Cancer Res,2012,72(4):908-916.
[13]Lin HY,Chiang CH,Hung WC.STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells[J].Br J Cancer,2013,109(3):731-738.
[14]Zaravinos A.The regulatory role of microRNAs in EMT and cancer[J].J Oncol,2015,2015:865816.
[15]Zhu S,Wu H,Wu F,et al.MicroRNA-21 targets tumor suppressor genes in invasion and metastasis[J].Cell Res,2008,18(3):350-359.
[16]Cai J,Fang L,Huang Y,et al.miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in nonsmall cell lung cancer[J].Cancer Res,2013,73(17):5402-5415.
[17]Tazawa H,Tsuchiya N,Izumiya M,et al.Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells[J].Proc Natl Acad Sci U S A,2007,104(39):15472-15477.
[18]Xiao C,Calado DP,Galler G,et al.MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb[J].Cell,2007,131(1):146-159.
[19]Huang Q,Gumireddy K,Schrier M,et al.The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis[J].Nat Cell Biol,2008,10(2):202-210.
[20]No authors listed.The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60,HSP70 and caspase-9 in cardiomyocytes[J].J Cell Sci,2011,124(Pt 18):3187.
[21]Cheng AM,Byrom MW,Shelton J,et al.Antisense inhibition of human miRNA and indications for an involvement of miRNA in cell growth and apoptosis[J].Nucleic Acids Res,2005,33(4):1290-1297.
[22]Desvignes T,Contreras A,Postlethwait JH.Evolution of the miR199-214 cluster and vertebrate skeletal development[J].RNABiol,2014,11(4):281-294.
[23]Lee YB,Bantounas I,Lee DY,et al.Twist-1 regulates the miR-199a/214 cluster during development[J].Nucleic Acids Res,2009,37(1):123-128.
[24]Weber MJ.New human and mouse microRNA genes found by homology search[J].FEBS J,2005,272(1):59-73.
[25]Salim H,Arvanitis A,De Petris L,et al.miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression[J].Genes Chromosomes Cancer,2013,52(10):895-911.
[26]Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
[27]Global Burden of Disease Cancer C,Fitzmaurice C,Dicker D,et al.The global burden of cancer 2013[J].JAMA Oncol,2015,1(4):505-527.
[28]Phatak P,Byrnes KA,Mansour D,et al.Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1[J].Oncogene,2016,35(16):2087-2097.
[29]Xu Y,Lu S.Regulation of beta-catenin-mediated esophageal cancer growth and invasion by miR-214[J].Am J Transl Res,2015,7(11):2316-2325.
[30]Herbst RS,Morgensztern D,Boshoff C.The biology and management of non-small cell lung cancer[J].Nature,2018,553(7689):446-454.
[31]Hirsch FR,Scagliotti GV,Mulshine JL,et al.Lung cancer:current therapies and new targeted treatments[J].Lancet,2017,389(10066):299-311.
[32]Zhang K,Zhang M,Jiang H,et al.Down-regulation of miR-214inhibits proliferation and glycolysis in non-small-cell lung cancer cells via down-regulating the expression of hexokinase 2 and pyruvate kinase isozyme M2[J].Biomed Pharmacother,2018,105:545-552.
[33]Liao J,Lin J,Lin D,et al.Down-regulation of miR-214 reverses erlotinib resistance in non-small-cell lung cancer through upregulating LHX6 expression[J].Sci Rep,2017,7(1):781.
[34]Fan L,Strasser-Weippl K,Li JJ,et al.Breast cancer in China[J].Lancet Oncol,2014,15(7):e279-e289.
[35]Orso F,Quirico L,Virga F,et al.miR-214 and miR-148b targeting inhibits dissemination of melanoma and breast cancer[J].Cancer Res,2016,76(17):5151-5162.
[36]Yi SJ,Li LL,Tu WB.MiR-214 negatively regulates proliferation and WNT/beta-catenin signaling in breast cancer[J].Eur Rev Med Pharmacol Sci,2016,20(24):5148-5154.
[37]Derfoul A,Juan AH,Difilippantonio MJ,et al.Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation,invasion and accumulation of the Polycomb Ezh2 methyltransferase[J].Carcinogenesis,2011,32(11):1607-1614.
[38]Yu X,Luo A,Liu Y,et al.MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy[J].Mol Cancer,2015,14:208.
[39]Hu JL,He GY,Lan XL,et al.Inhibition of ATG12-mediated autophagy by miR-214 enhances radiosensitivity in colorectal cancer[J].Oncogenesis,2018,7(2):16.
[40]Chen D L,Wang ZQ,Zeng ZL,et al.Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor1 expression[J].Hepatology,2014,60(2):598-609.
[41]Chandrasekaran KS,Sathyanarayanan A,Karunagaran D.Micro RNA-214 suppresses growth,migration and invasion through a novel target,high mobility group AT-hook 1,in human cervical and colorectal cancer cells[J].Br J Cancer,2016,115(6):741-751.
[42]He GY,Hu JL,Zhou L,et al.The FOXD3/miR-214/MED19 axis suppresses tumour growth and metastasis in human colorectal cancer[J].Br J Cancer,2016,115(11):1367-1378.
[43]Alexandrov LB,Nik-Zainal S,Wedge DC,et al.Signatures of mutational processes in human cancer[J].Nature,2013,500(7463):415-421.
[44]Yang H,Kong W,He L,et al.MicroRNA expression profiling in human ovarian cancer:miR-214 induces cell survival and cisplatin resistance by targeting PTEN[J].Cancer Res,2008,68(2):425-433.
[45]Yin G,Chen R,Alvero AB,et al.TWISTing stemness,inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214[J].Oncogene,2010,29(24):3545-3553.
[46]Shih TC,Tien YJ,Wen CJ,et al.MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma[J].J Hepatol,2012,57(3):584-591.
[47]Wang J,Li J,Wang X,et al.Downregulation of microRNA-214and overexpression of FGFR-1 contribute to hepatocellular carcinoma metastasis[J].Biochem Biophys Res Commun,2013,439(1):47-53.
[48]Wang X,Chen J,Li F,et al.MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of beta-catenin[J].Biochem Biophys Res Commun,2012,428(4):525-531.
[49]Wang F,Liu M,Li X,et al.MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2L2 in cervical cancer cells[J].FEBS Lett,2013,587(5):488-495.
[50]Dettori D,Orso F,Penna E,et al.Therapeutic silencing of miR-214inhibits tumor progression in multiple mouse models[J].Mol Ther,2018,26(8):2008-2018.
[51]Andersson R,Aho U,Nilsson B I,et al.Gemcitabine chemoresistance in pancreatic cancer:molecular mechanisms and potential solutions[J].Scand J Gastroenterol,2009,44(7):782-786.
[52]Zhang XJ,Ye H,Zeng CW,et al.Dysregulation of miR-15a and miR-214 in human pancreatic cancer[J].J Hematol Oncol,2010,3:46.
[53]Xu C,He T,Li Z,et al.Regulation of HOXA11-AS/miR-214-3p/EZH2 axis on the growth,migration and invasion of glioma cells[J].Biomed Pharmacother,2017,95:1504-1513.
[54]Wang J,Zhang X,Wang L,et al.MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1in bladder cancer[J].PLoS One,2015,10(2):e0118086.
[55]Yang L,Zhang W,Wang Y,et al.Hypoxia-induced miR-214expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells[J].Cancer Lett,2018,414:44-56.
[56]Yang TS,Yang XH,Wang XD,et al.MiR-214 regulate gastric cancer cell proliferation,migration and invasion by targeting PTEN[J].Cancer Cell Int,2013,13(1):68.
[57]Yin Y,Cai X,Chen X,et al.Tumor-secreted miR-214 induces regulatory T cells:a major link between immune evasion and tumor growth[J].Cell Res,2014,24(10):1164-1180.