人miRNA-483与疾病最新研究进展
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摘要
MicroRNA(miRNA)是一类内源基因编码的长度为22个左右核苷酸的单链非编码RNA,广泛存在于真核细胞中,通过作用于特异靶分子mRNA的3'-UTR,导致该m RNA直接降解或抑制其翻译过程,发挥转录后水平调控基因表达作用。人miRNA-483来源于类胰岛素生长因子2(Insulin-like growth factor 2,IGF2)的第2内含子,经加工为miR-483-3p和miR-483-5p两个成熟体形式。近几年的研究发现人miRNA-483是一种非常重要的miRNA分子,目前已通过实验验证了10余个靶基因,通过调控靶基因参与了肿瘤发生和心血管等疾病发病过程。本文对人miRNA-483参与多种肿瘤、心血管和青光眼等多种疾病过程最新的研究进展作一综述。
MicroRNAs(miRNAs)are a class of endogenous sigle-strand non-coding small RNAs with length about 22 nucleotides(nt), widely exist in eukaryotic cells. By targeting specific m RNA 3'-UTR, mi RNA causes the degradation or translation inhibition of target m RNA directly, which plays the role of post transcriptional regulation of gene expression. Human mi RNA-483 is an important component of the family of mi RNAs, which origins from 2 nd intron of insulin-like growth factor 2, mainly including mi R-483-3 p and mi R-483-5 p mature moleculars. The recent studies found that mi RNA-483 is closely related to tumorigenesis and cardiovascular diseases.Up to date, over 10 target genes regulated by mi R-483-3 p or mi R-483-5 p have been identified by experiments. In this paper, we review the recent progress of mi RNA-483 in tumorigenesis, cardiovascular diseases, glaucoma and so on.
MicroRNAs(miRNAs)are a class of endogenous sigle-strand non-coding small RNAs with length about 22 nucleotides(nt), widely exist in eukaryotic cells. By targeting specific m RNA 3'-UTR, mi RNA causes the degradation or translation inhibition of target m RNA directly, which plays the role of post transcriptional regulation of gene expression. Human mi RNA-483 is an important component of the family of mi RNAs, which origins from 2 nd intron of insulin-like growth factor 2, mainly including mi R-483-3 p and mi R-483-5 p mature moleculars. The recent studies found that mi RNA-483 is closely related to tumorigenesis and cardiovascular diseases.Up to date, over 10 target genes regulated by mi R-483-3 p or mi R-483-5 p have been identified by experiments. In this paper, we review the recent progress of mi RNA-483 in tumorigenesis, cardiovascular diseases, glaucoma and so on.
引文
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[2]Chang CW,Yu JC,Hsieh YH,et al.Micro RNA-30a increases tight junction protein expression to suppress the epithelial-mesenchymal transition and metastasis by targeting Slug in breast cancer[J].Oncotarget,2016,7(13):16462-16478
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[14]Li F,Ma N,Zhao R,et al.Overexpression of mi R-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-βstimulated HSCs in transgenic mice[J].Journal Cellular Molecular Medicine,2014,18(6):966-974
[15]Hao J,Zhang S,Zhou Y,Hu X,et al.Micro RNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer[J].FEBS Letter,2011,585(1):207-213
[16]Ma J,Hong L,Xu G,et al.mi R-483-3p plays an oncogenic role in esophageal squamous cell carcinoma by targeting tumor suppressor EI24[J].Cell Biololgy International,2016,40(4):448-455
[17]Cui H,Liu Y,Jiang J,et al.IGF2-derived mi R-483 mediated oncofunction by suppressing DLC-1 and associated with colorectal cancer[J].Oncotarget,2016[Epubaheadofprint]
[18]Wang C,Sun Y,Wu H,et al.Elevated mi R-483-3p expression is an early event and indicates poor prognosis in pancreatic ductal adenocarcinoma[J].Tumour Biology,2015,36(12):9447-9456
[19]Patterson EE,Holloway AK,Weng J,et al.Micro RNA profiling of adrenocortical tumors reveals mi R-483 as a marker of malignancy[J].Cancer,2011,117(8):1630-1639
[20]Song Q,Xu Y,Yang C,et al.mi R-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting Rho GDI1 and ALCAM[J].Cancer Research,2014,74(11):3031-3042
[21]Qu X,Zhao M,Wu S,et al.Circulating micro RNA 483-5p as a novel biomarker for diagnosis survival prediction in multiple myeloma[J].Medical Oncology,2014,31(10):219
[22]Wang L,Shi M,Hou S,et al.Mi R-483-5p suppresses the proliferation of glioma cells via directly targeting ERK1[J].FEBS Letter,2012,586(9):1312-1317
[23]Bertero T,Bourget-Ponzio I,Puissant A,et al.Tumor suppressor function of mi R-483-3p on squamous cell carcinomas due to its pro-apoptotic properties[J].Cell Cycle,2013,12(14):2183-2193
[24]Qiao Y,Ma N,Wang X,et al.Mi R-483-5p controls angiogenesis in vitro and targets serum response factor[J].FEBS Letter,2011,585(19):3095-3100
[25]Kong L,Hu N,Du X,et al.Up regulation of mi R-483-3p contributes to endothelial progenitor cells dysfunction in deep vein thrombosis patients via SRF[J].Journal of Translational Medicine,2016,14:23[Epub ahead of print]
[26]Qiao Y,Zhao Y,Liu Y,et al.mi R-483-3p regulates hyperglycaemiainduced cardiomyocyte apoptosis in transgenic mice[J].Biochemical and Biophysical Research Communications,2016,477(4):541-547
[27]Bertero T,Gastaldi C,Bourget-Ponzio I,et al.mi R-483-3p controls proliferation in wounded epithelial cells[J].FASEB Journal,2011,25(9):3092-3105
[28]Bertero T,Gastaldi C,Bourget-Ponzio I,et al.CDC25A targeting by mi R-483-3p decreases CCND-CDK4/6 assembly and contributes to cell cycle arrest[J].Cell Death Differentiation,2013,20(6):800-811
[29]Shen W,Han Y,Huang B,et al.Micro RNA-483-3p inhibits extracellular matrix production by targeting Smad4 in human trabecular meshwork cells[J].Investigative Ophthalmology&Visual Science,2015,56(13):8419-8427
[30]Chen K,He H,Xie Y,et al.mi R-125a-3p and mi R-483-5p promote adipogenesis via suppressing the Rho A/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis[J].Science Report,2015,5:11909[Epub ahead of print]
[2]Chang CW,Yu JC,Hsieh YH,et al.Micro RNA-30a increases tight junction protein expression to suppress the epithelial-mesenchymal transition and metastasis by targeting Slug in breast cancer[J].Oncotarget,2016,7(13):16462-16478
[3]Cheng W,Yan K,Xie LY,et al.Mi R-143-3p controls TGF-β1-induced cell proliferation and extracellular matrix production in airway smooth muscle via negative regulation of the nuclear factor of activated T cells 1[J].Molecular Immunology,2016,78:133-139
[4]Niu X,Fu N,Du J,et al.mi R-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis[J].FEBS Letter,2016,590(16):2709-2724
[5]Tomasetti M,Monaco F,Manzella N,et al.Micro RNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma[J].Oncotarget,2016[Epub ahead of print]
[6]He J,Yu JJ,Xu Q,et al.Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy[J].Autophagy,2015,11(2):373-384
[7]Bhattacharya A,Schmitz U,Raatz Y,et al.mi R-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy[J].Oncotarget,2015,6(5):2966-2980
[8]Peng XP,Huang L,Liu ZH.mi RNA-133a attenuates lipid accumulation via TR4-CD36 pathway in macrophages[J].Biochimie,2016,127:79-85
[9]Veronese A,Lupini L,Consiglio J,et al.Oncogenic role of mi R-483-3p at the IGF2/483 locus[J].Cancer Research,2010,70(8):3140-3149
[10]Ma N,Li F,Li D,et al.Igf2-derived intronic mi R-483 promotes mouse hepatocellular carcinoma cell proliferation[J].Molecular and Cellular Biochemistry,2012,361(1-2):337-343
[11]Zhang Z,Ge S,Wang X,et al.Serum mi R-483-5p as a potential biomarker to detect hepatocellular carcinoma[J].Hepatology International,2013,7(1):199-207
[12]Shen J,Wang A,Wang Q,et al.Exploration of genome-wide circulating micro RNA in hepatocellular carcinoma:Mi R-483-5p as a potential biomarker[J].Cancer Epidemiology Biomarkers Prevention,2013,22(12):2364-2373
[13]Lupini L,Pepe F,Ferracin M,et al.Over-expression of the mi R-483-3p overcomes the mi R-145/TP53 pro-apoptotic loop in hepatocellular carcinoma[J].Oncotarget,2016,7(21):31361-31371
[14]Li F,Ma N,Zhao R,et al.Overexpression of mi R-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-βstimulated HSCs in transgenic mice[J].Journal Cellular Molecular Medicine,2014,18(6):966-974
[15]Hao J,Zhang S,Zhou Y,Hu X,et al.Micro RNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer[J].FEBS Letter,2011,585(1):207-213
[16]Ma J,Hong L,Xu G,et al.mi R-483-3p plays an oncogenic role in esophageal squamous cell carcinoma by targeting tumor suppressor EI24[J].Cell Biololgy International,2016,40(4):448-455
[17]Cui H,Liu Y,Jiang J,et al.IGF2-derived mi R-483 mediated oncofunction by suppressing DLC-1 and associated with colorectal cancer[J].Oncotarget,2016[Epubaheadofprint]
[18]Wang C,Sun Y,Wu H,et al.Elevated mi R-483-3p expression is an early event and indicates poor prognosis in pancreatic ductal adenocarcinoma[J].Tumour Biology,2015,36(12):9447-9456
[19]Patterson EE,Holloway AK,Weng J,et al.Micro RNA profiling of adrenocortical tumors reveals mi R-483 as a marker of malignancy[J].Cancer,2011,117(8):1630-1639
[20]Song Q,Xu Y,Yang C,et al.mi R-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting Rho GDI1 and ALCAM[J].Cancer Research,2014,74(11):3031-3042
[21]Qu X,Zhao M,Wu S,et al.Circulating micro RNA 483-5p as a novel biomarker for diagnosis survival prediction in multiple myeloma[J].Medical Oncology,2014,31(10):219
[22]Wang L,Shi M,Hou S,et al.Mi R-483-5p suppresses the proliferation of glioma cells via directly targeting ERK1[J].FEBS Letter,2012,586(9):1312-1317
[23]Bertero T,Bourget-Ponzio I,Puissant A,et al.Tumor suppressor function of mi R-483-3p on squamous cell carcinomas due to its pro-apoptotic properties[J].Cell Cycle,2013,12(14):2183-2193
[24]Qiao Y,Ma N,Wang X,et al.Mi R-483-5p controls angiogenesis in vitro and targets serum response factor[J].FEBS Letter,2011,585(19):3095-3100
[25]Kong L,Hu N,Du X,et al.Up regulation of mi R-483-3p contributes to endothelial progenitor cells dysfunction in deep vein thrombosis patients via SRF[J].Journal of Translational Medicine,2016,14:23[Epub ahead of print]
[26]Qiao Y,Zhao Y,Liu Y,et al.mi R-483-3p regulates hyperglycaemiainduced cardiomyocyte apoptosis in transgenic mice[J].Biochemical and Biophysical Research Communications,2016,477(4):541-547
[27]Bertero T,Gastaldi C,Bourget-Ponzio I,et al.mi R-483-3p controls proliferation in wounded epithelial cells[J].FASEB Journal,2011,25(9):3092-3105
[28]Bertero T,Gastaldi C,Bourget-Ponzio I,et al.CDC25A targeting by mi R-483-3p decreases CCND-CDK4/6 assembly and contributes to cell cycle arrest[J].Cell Death Differentiation,2013,20(6):800-811
[29]Shen W,Han Y,Huang B,et al.Micro RNA-483-3p inhibits extracellular matrix production by targeting Smad4 in human trabecular meshwork cells[J].Investigative Ophthalmology&Visual Science,2015,56(13):8419-8427
[30]Chen K,He H,Xie Y,et al.mi R-125a-3p and mi R-483-5p promote adipogenesis via suppressing the Rho A/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis[J].Science Report,2015,5:11909[Epub ahead of print]