microRNA-3147在宫颈癌中的表达及意义
摘要
目的分析microRNA-3147在宫颈癌患者以及正常人血液中的表达情况及其与宫颈癌患者临床病理参数之间的相关性。方法选择宫颈癌患者以及健康查体者各100例分别作为患者组和正常组,采用实时荧光定量PCR法检测2组受检者血液中microRNA-3147表达量,分析其与宫颈癌临床病理参数之间的相关性,绘制ROC曲线探讨其在宫颈癌诊断中的价值。结果患者组血液中microRNA-3147表达量明显高于正常组(P<0.05),ROC曲线下面积为0.932;血液中microRNA-3147表达量与患者年龄、肿瘤类型不相关(P均>0.05),但与肿瘤大小、分化程度、转移状态相关(P均<0.05)。结论血清中microRNA-3147的表达量对宫颈癌的早期诊断、预后和治疗有一定的指导意义。
引文
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[4] Sharma S,Mandal P,Sadhukhan T,et al.Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis[J].Sci Rep,2015,5:11724
[5] Ramakrishnan S,Partricia S,Mathan G.Overview of hi-gh-risk HPV’s 16 and 18 infected cervical cancer:pathogenesis to prevention[J].Biomed Pharmacother,2015,70:103-110
[6] Deng B,Zhang Y,Zhang S,et al.MicroRNA-142-3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7[J].Tumour Biol,2015,36(10):8065-8073
[7] Chen J,Yao D,Li Y,et al.Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma[J].Int J Mol Med,2013,32(3):557-567
[8] Li MY,Hu XX.Meta-analysis of microRNA expression profiling studies in human cervical cancer[J].Med Oncol,2015,32(6):510
[9] Gocze K,Gombos K,Kovacs K,et al.MicroRNA expressions in HPV-induced cervical dysplasia and cancer[J].Anticancer Res,2015,35(1):523-530
[10] Liu S,Pan X,Yang Q,et al.MicroRNA-18a enhances the radiosensitivity of cervical cancer cells by promoting radiation-induced apoptosis[J].Oncol Rep,2015,33(6):2853-2862
[11] Kong Y,Wu JB,Wang X,et al.Polymorphism of the O-LR1 3'UTR potential microRNA binding site and risk of Alzheimer’s disease:a meta-analysis[J].Genet Mol Res,2014,13(4):10162-10172
[12] Langevin SM,Christensen BC.Let-7 microRNA-binding-site polymorphism in the 3’UTR of KRAS and colorectal cancer outcome:a systematic review and meta-analysis[J].Cancer Med,2014,3(5):1385-1395
[13] Wang X,Tang S,Le SY,et al.Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth[J].PLoS One,2008,3(7):e2557