云浮市云城区小细胞低色素性贫血孕妇的病因分析
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摘要
目的了解和分析本地区小细胞低色素性贫血孕妇的病因,为临床诊断和治疗提供科学的根据,从而提高本地区的优生优育。方法选取2017年1月～2018年10月在我院进行产检的50例小细胞低色素性贫血孕妇地贫基因和铁蛋白的检测结果,进行回顾性分析,将这类孕妇按地中海贫血、缺铁性贫血、地中海贫血合并缺铁性贫血和其他类贫血四大类型进行分析。结果单纯携带地贫基因30例,占总数的60%,单纯缺铁性贫血6例,占总数的12%,地中海贫血合并缺铁性贫血6例,占总数的12%,其他类型贫血8例,占总数的16%。结论本地区孕妇小细胞低色素性贫血主要病因是地中海贫血。为了提高本地区的优生优育,地中海贫血筛查和地中海贫血基因的检测在此类孕妇产检中尤为重要。
Objective To understand and analyze etiology of pregnant women with microcytic hypochromic anemia in this region to provide scientific basis for clinical diagnosis and treatment, so as to improve prepotencyin this region.Methods Detection results ofthalassemia gene and ferritin of 50 pregnant women with microcytic hypochromic anemia who underwent antenatal care in our hospital from January 2017 to October 2018 were selected and they were retrospectively statistically analyzed. Such pregnant women were analyzed according to four major types such as thalassemia, iron deficiency anemia, thalassemia combined with iron deficiency anemia and other types of anemia. Results 30 cases that simply carried the thalassemia gene accounted for 60% of the total. 6 cases of iron deficiency anemiaaccounted for12% of the total.6 cases of thalassemia combined with iron deficiency anemiaaccounted for 12% of the total. 8 cases of other types of anemia accounted for 16% of the total. Conclusion The main etiology of microcytic hypochromic anemia in pregnant women in this region is thalassemia.In order to improve the prepotency in the region, screening for thalassemia and detection of thalassemia genes is particularly important in the screening of such pregnant women.
Objective To understand and analyze etiology of pregnant women with microcytic hypochromic anemia in this region to provide scientific basis for clinical diagnosis and treatment, so as to improve prepotencyin this region.Methods Detection results ofthalassemia gene and ferritin of 50 pregnant women with microcytic hypochromic anemia who underwent antenatal care in our hospital from January 2017 to October 2018 were selected and they were retrospectively statistically analyzed. Such pregnant women were analyzed according to four major types such as thalassemia, iron deficiency anemia, thalassemia combined with iron deficiency anemia and other types of anemia. Results 30 cases that simply carried the thalassemia gene accounted for 60% of the total. 6 cases of iron deficiency anemiaaccounted for12% of the total.6 cases of thalassemia combined with iron deficiency anemiaaccounted for 12% of the total. 8 cases of other types of anemia accounted for 16% of the total. Conclusion The main etiology of microcytic hypochromic anemia in pregnant women in this region is thalassemia.In order to improve the prepotency in the region, screening for thalassemia and detection of thalassemia genes is particularly important in the screening of such pregnant women.
引文
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[13]熊符,娄季武,魏小凤,等.广西地区79例α-地中海贫血复合β-地中海贫血患者血液学特征分析[J].中华血液学杂志,2012,33(10):856-860.
[14]李育敏,蒋淑萍,李俭,等.新生儿重型α地中海贫血1例报告及文献复习[J].临床检验杂志,2018,36(7):555-557.
[2]梁丽云,黎四平,徐炳燕,等.血清铁调素对小细胞低色素性贫血鉴别诊断的意义[J].吉林医学,2015,36(12):2502-2503.
[3]谢建渝,虞柯静,罗文梅,等.423例孕妇地中海贫血筛查及基因检测结果分析和临床意义[J].检验医学与临床,2014,11(10):1325-1327,1330.
[4]张之南.血液病诊断及疗效标准[M].北京:科学出版社,1998:10-12.
[5]江炎章.广东省云浮地区女性和儿童地中海贫血基因分型情况分析[J].现代医院,2018,18(2):234-236,239.
[6]刘朔婕,孙鸣,黄宇,等.闽南地区罕见α地中海贫血基因型分析[J].医学分子生物学杂志,2016,13(6):311-316.
[7]潘翠琦,白杨,刘冬,等.缺失型α-地中海贫血基因携带者红细胞参数特征研究[J].国际检验医学杂志2014,35(14):1836-1838.
[8]谭齐贤,张树平.临床血液学和血液检验[M].北京:人民卫生出版社,2006:147-148.
[9]Xu XM,Zhou YQ,Luo GX,et a1.The prevalence and spectrum ofαandβthalassaemia in Guangdong province:implications for the future health burden and population screening[J].J Clin Pathol,2004,57(5):517-522.
[10]张新华,周英杰,李平萍,等.广西南宁市农村育龄人群地中海贫血筛查及基因型和血液学参数分析[J].中华流行病学杂志,2006,27(9):769-772.
[11]晁艳,冯琴,余伍忠,等.常见类型地中海贫血患者全血细胞计数参数特点[J].中国生育健康杂志,2013,24(6):26-28.
[12]Xiong F,Sun M,Zhang X,et al.Molecular epidemiological survey of haemoglobinopathies in The Guangxi Zhuang Autonomous Region of southern China[J].Clin Genet,2010,78(2):139-148.
[13]熊符,娄季武,魏小凤,等.广西地区79例α-地中海贫血复合β-地中海贫血患者血液学特征分析[J].中华血液学杂志,2012,33(10):856-860.
[14]李育敏,蒋淑萍,李俭,等.新生儿重型α地中海贫血1例报告及文献复习[J].临床检验杂志,2018,36(7):555-557.