慢性荨麻疹患者淋巴细胞指标、D-二聚体和炎性因子指标变化及预后分析
|
摘要
目的探讨慢性荨麻疹(CU)患者淋巴细胞指标、D-二聚体和炎性因子指标变化及预后情况。方法选取该院2016年1月至2017年1月接诊的60例CU患者进行研究(观察组),另选60例体检健康者作为对照组,检测入选患者外周血T淋巴细胞指标(CD3~+、CD3~+CD4~+)、B淋巴细胞指标CD3-CD19~+、D-二聚体、肿瘤坏死因子-α(TNF-α)、炎症因子白介素-6 (IL-6)水平并分析血液学指标对预后的影响。结果观察组血清CD3~+、CD3~+CD4~+及CD3-CD19~+水平均显著低于对照组,差异有统计学意义(P<0.05);观察组D-二聚体、TNF-α及IL-6水平均显著高于对照组,差异有统计学意义(P<0.05);60例CU患者采用不同治疗方法,治愈13例,显效32例,进步8例,无效7例,治疗后总有效率为75%(45/60),采用自穴位注射治疗,治疗后效果明显优于氯雷他定片,差异有统计学意义(P<0.05)。结论 CU患者T、B淋巴细胞指标能有效反映患者疾病发展情况,D-二聚体、TNF-α及IL-6水平升高,证明其参与了患者的疾病发展,患者治疗后疗效较好,临床作用明显。
Objective To investigate the changes of lymphocyte index,D-dimer and inflammatory factors in patients with chronic urticaria and their prognosis.Methods 60 patients with chronic urticaria received in a hospital from January 2016 to January 2017 were studied.Chronic urticaria was used as observation group.60 healthy persons were selected as control group.The T lymphocyte index(CD3~+,CD3~+CD4~+),B lymphocyte index(CD3-CD19~+),D-dimer,tumor necrosis factor-alpha(TNF-α),inflammatory factor interleukin-6(IL-6)levels were detected in the peripheral blood of the patients,and analysis of hematological parameters on prognosis.Results The serum levels of CD3~+,CD3~+CD4~+ and CD3-CD19~+ in observation group were significantly lower than those in control group,the difference was statistically significant(P<0.05).The levels of D-dimer,TNF-αand IL-6 in the observation group were significantly higher than those in control group,the difference was statistically significant(P<0.05).60 cases of chronic urticaria were treated with different treatment methods,13 cases were cured,32 cases were markedly effective,8 cases were improved and 7 cases were invalid.The total effective rate was 75%(45/60)after treatment.The effect of acupoint injection was better than that of Loratadine Tablets,the difference was statistically significant(P<0.05).Conclusion The T and B lymphocyte indexes in patients with chronic urticaria can effectively reflect the development of the patients,and the levels of D-dimer,TNF-αand IL-6 have increased,which is proved that the patients are involved in the development of the patients.The patients have good curative effect and the clinical effect is obvious after treatment.
Objective To investigate the changes of lymphocyte index,D-dimer and inflammatory factors in patients with chronic urticaria and their prognosis.Methods 60 patients with chronic urticaria received in a hospital from January 2016 to January 2017 were studied.Chronic urticaria was used as observation group.60 healthy persons were selected as control group.The T lymphocyte index(CD3~+,CD3~+CD4~+),B lymphocyte index(CD3-CD19~+),D-dimer,tumor necrosis factor-alpha(TNF-α),inflammatory factor interleukin-6(IL-6)levels were detected in the peripheral blood of the patients,and analysis of hematological parameters on prognosis.Results The serum levels of CD3~+,CD3~+CD4~+ and CD3-CD19~+ in observation group were significantly lower than those in control group,the difference was statistically significant(P<0.05).The levels of D-dimer,TNF-αand IL-6 in the observation group were significantly higher than those in control group,the difference was statistically significant(P<0.05).60 cases of chronic urticaria were treated with different treatment methods,13 cases were cured,32 cases were markedly effective,8 cases were improved and 7 cases were invalid.The total effective rate was 75%(45/60)after treatment.The effect of acupoint injection was better than that of Loratadine Tablets,the difference was statistically significant(P<0.05).Conclusion The T and B lymphocyte indexes in patients with chronic urticaria can effectively reflect the development of the patients,and the levels of D-dimer,TNF-αand IL-6 have increased,which is proved that the patients are involved in the development of the patients.The patients have good curative effect and the clinical effect is obvious after treatment.
引文
[1]高广程,许颖.慢性荨麻疹过敏原检测的临床意义及可能的病因分析[J].临床和实验医学杂志,2015,14(1):1207-1210.
[2]张飞娟,白莉.慢性荨麻疹患者外周血中白细胞介素25、17的表达及意义[J].中国中西医结合皮肤性病学杂志,2016,15(1):16-18.
[3]王进,陈健.中西医结合治疗慢性荨麻疹临床疗效观察及安全性评价[J].中华中医药学刊,2015,33(3):766-768.
[4]何清.慢性荨麻疹患者血液学指标的变化及相关性研究[J].国际检验医学杂志,2017,38(5):694-695.
[5]黄桃源,杨文林,尹嘉文,等.急性时相反应标志物及凝血、纤溶标志物与慢性荨麻疹的相关性研究[J].中华皮肤科杂志,2014,47(7):473-476.
[6]郭霞.慢性荨麻疹患者血液学指标的改变及对预后的影响[J].中华全科医学,2015,13(11):1789-1790.
[7]梁碧华,李振洁,李润祥,等.几种炎症因子与慢性荨麻疹的相关性[J].中国麻风皮肤病杂志,2014,30(11):657-659.
[8]陈云龙,陈文峰,林阿丰.自血疗法辨证治疗慢性荨麻疹30例[J].光明中医,2011,22(3):490-491.
[9]王亚贤,王晓婷,王岩.观察卡介菌多糖核酸联合地氯雷他定治疗慢性荨麻疹的疗效[J].中国医药指南,2017,15(21):75-76.
[10]CHRISTIAN V,METTE D.Chronic spontaneous urticaria:latest developments in aetiology,diagnosis and therapy[J].Therap Chro Dis,2015,6(6):304-313.
[11]蒲继红,郭志武,孙任苓,等.自血疗法治疗慢性荨麻疹疗效与安全性的系统评价[J].护理研究,2017,31(19):2351-2355.
[12]种玲玲,袁永革,徐益明.慢性荨麻疹发作期与缓解期患者血清IL-4、IL-10、IL-25、IFN-γ水平变化及意义[J].山东医药,2015,55(45):81-82.
[13]KLOSSOWSKI N,BRAUN S A,VON GRUBE N,et al.Acquired angioedema with C1-INH deficiency and accompanying chronic spontaneous urticaria in a patient with chronic lymphatic B cell leukemia[J].Der Hautar,2015,66(10):723-725.
[14]谭全邦,喻洪芝,张俊豪.麻黄附子细辛汤联合枸地氯雷他定片治疗慢性荨麻疹对血清总IgE水平的影响[J].现代中西医结合杂志,2015,24(29):3251-3253.
[15]王焯.匹多莫德对慢性荨麻疹患者免疫状况的影响及其疗效[J].实用药物与临床,2015,18(6):684-686.
[16]靳情.血清总IgE与食物特异性IgG检测在慢性荨麻疹和慢性湿疹中的应用评价[J].蚌埠医学院学报,2015,40(4):479-481.
[17]郭敏,白莉.慢性荨麻疹患者血清IL-35和IL-17的检测[J].中国麻风皮肤病杂志,2016,32(2):85-87.
[18]赵艳霞,嬴双.浅析慢性荨麻疹临床预防与治疗要点[J].中国中西医结合皮肤性病学杂志,2015,14(3):183-185.
[19]HYANG S Y,HYUN H C,WON J K,et al.Autologous whole blood injection for the treatment of antihistamineresistant chronic spontaneous urticaria[J].Annals Dermatol,2015,27(6):784-786.
[20]黎国栋,吴洪文,赵金柳.氯雷他定联合西替利嗪治疗慢性荨麻疹的疗效及对血清IgE水平的影响[J].医学综述,2017,23(2):406-409.
[21]刘军连,徐冰心,王晓菲,等.自身免疫性慢性荨麻疹患者外周血单个核细胞TLR7的表达和意义[J].实用预防医学,2015,22(6):651-654.
[22]刘佳,农祥.凝血机制参与慢性荨麻疹发病的研究进展[J].国际皮肤性病学杂志,2016,42(1):33-36.
[23]刘麟,郑海霞.地氯雷他定联合孟鲁斯特钠治疗慢性荨麻疹疗效评价[J].中国麻风皮肤病杂志,2015,21(4):227-228.
[24]蒋屏东,孙慧,郑渊,等.地氯雷他定联合卡介菌多糖核酸治疗慢性荨麻疹的临床疗效及对免疫功能的影响[J].贵州医药,2017,41(11):1178-1179.
[25]陈华秀,马丽俐,熊雪,等.慢性荨麻疹患者病情严重程度与免疫五项的相关性分析[J].中国麻风皮肤病杂志,2017,33(1):34-36.
[2]张飞娟,白莉.慢性荨麻疹患者外周血中白细胞介素25、17的表达及意义[J].中国中西医结合皮肤性病学杂志,2016,15(1):16-18.
[3]王进,陈健.中西医结合治疗慢性荨麻疹临床疗效观察及安全性评价[J].中华中医药学刊,2015,33(3):766-768.
[4]何清.慢性荨麻疹患者血液学指标的变化及相关性研究[J].国际检验医学杂志,2017,38(5):694-695.
[5]黄桃源,杨文林,尹嘉文,等.急性时相反应标志物及凝血、纤溶标志物与慢性荨麻疹的相关性研究[J].中华皮肤科杂志,2014,47(7):473-476.
[6]郭霞.慢性荨麻疹患者血液学指标的改变及对预后的影响[J].中华全科医学,2015,13(11):1789-1790.
[7]梁碧华,李振洁,李润祥,等.几种炎症因子与慢性荨麻疹的相关性[J].中国麻风皮肤病杂志,2014,30(11):657-659.
[8]陈云龙,陈文峰,林阿丰.自血疗法辨证治疗慢性荨麻疹30例[J].光明中医,2011,22(3):490-491.
[9]王亚贤,王晓婷,王岩.观察卡介菌多糖核酸联合地氯雷他定治疗慢性荨麻疹的疗效[J].中国医药指南,2017,15(21):75-76.
[10]CHRISTIAN V,METTE D.Chronic spontaneous urticaria:latest developments in aetiology,diagnosis and therapy[J].Therap Chro Dis,2015,6(6):304-313.
[11]蒲继红,郭志武,孙任苓,等.自血疗法治疗慢性荨麻疹疗效与安全性的系统评价[J].护理研究,2017,31(19):2351-2355.
[12]种玲玲,袁永革,徐益明.慢性荨麻疹发作期与缓解期患者血清IL-4、IL-10、IL-25、IFN-γ水平变化及意义[J].山东医药,2015,55(45):81-82.
[13]KLOSSOWSKI N,BRAUN S A,VON GRUBE N,et al.Acquired angioedema with C1-INH deficiency and accompanying chronic spontaneous urticaria in a patient with chronic lymphatic B cell leukemia[J].Der Hautar,2015,66(10):723-725.
[14]谭全邦,喻洪芝,张俊豪.麻黄附子细辛汤联合枸地氯雷他定片治疗慢性荨麻疹对血清总IgE水平的影响[J].现代中西医结合杂志,2015,24(29):3251-3253.
[15]王焯.匹多莫德对慢性荨麻疹患者免疫状况的影响及其疗效[J].实用药物与临床,2015,18(6):684-686.
[16]靳情.血清总IgE与食物特异性IgG检测在慢性荨麻疹和慢性湿疹中的应用评价[J].蚌埠医学院学报,2015,40(4):479-481.
[17]郭敏,白莉.慢性荨麻疹患者血清IL-35和IL-17的检测[J].中国麻风皮肤病杂志,2016,32(2):85-87.
[18]赵艳霞,嬴双.浅析慢性荨麻疹临床预防与治疗要点[J].中国中西医结合皮肤性病学杂志,2015,14(3):183-185.
[19]HYANG S Y,HYUN H C,WON J K,et al.Autologous whole blood injection for the treatment of antihistamineresistant chronic spontaneous urticaria[J].Annals Dermatol,2015,27(6):784-786.
[20]黎国栋,吴洪文,赵金柳.氯雷他定联合西替利嗪治疗慢性荨麻疹的疗效及对血清IgE水平的影响[J].医学综述,2017,23(2):406-409.
[21]刘军连,徐冰心,王晓菲,等.自身免疫性慢性荨麻疹患者外周血单个核细胞TLR7的表达和意义[J].实用预防医学,2015,22(6):651-654.
[22]刘佳,农祥.凝血机制参与慢性荨麻疹发病的研究进展[J].国际皮肤性病学杂志,2016,42(1):33-36.
[23]刘麟,郑海霞.地氯雷他定联合孟鲁斯特钠治疗慢性荨麻疹疗效评价[J].中国麻风皮肤病杂志,2015,21(4):227-228.
[24]蒋屏东,孙慧,郑渊,等.地氯雷他定联合卡介菌多糖核酸治疗慢性荨麻疹的临床疗效及对免疫功能的影响[J].贵州医药,2017,41(11):1178-1179.
[25]陈华秀,马丽俐,熊雪,等.慢性荨麻疹患者病情严重程度与免疫五项的相关性分析[J].中国麻风皮肤病杂志,2017,33(1):34-36.