子宫内膜异位症大鼠模型研究进展
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摘要
为临床深入研究子宫内膜异位症(EMs)的病因、发病机制、治疗药物和预防对策提供合理的大鼠模型。本文对EMs大鼠模型的发病机制、建模方法、优化措施、评价标准以及模型应用等进行综合阐述和比较,研究者可根据实验需要选择合适的建模方法,使其更加贴合实验及临床研究的需要。
In order to establish reliable rat model to study the etiology, pathogenesis and treatment of endometriosis, this article reviewed the literature on the rat model of endometriosis, including the pathogenesis, modeling method, the refinement, evaluation criterion and the application of rat endometriosis model. This review may offer an important reference for choosing animal models to study endometriosis in the future.
In order to establish reliable rat model to study the etiology, pathogenesis and treatment of endometriosis, this article reviewed the literature on the rat model of endometriosis, including the pathogenesis, modeling method, the refinement, evaluation criterion and the application of rat endometriosis model. This review may offer an important reference for choosing animal models to study endometriosis in the future.
引文
[1]中华医学会妇产科学会分会子宫内膜异位症协作组.子宫内膜异位症的诊治指南[J].中华妇产科杂志,2015,50(3):161-169.
[2]崔阳阳,孙伟伟,赵瑞华.子宫内膜异位症动物模型的研究进展[J].中国实验动物学报,2013,21(10):87-89.
[3]李凤英.子宫内膜异位症的临床特点及其发病机制探讨[J].医学前沿,2018,8(8):234-235.
[4]成萍,纪燕琴.子宫内膜异位症发病机制的研究进展[J].中华妇幼临床医学杂志,2015,11(1):117-119.
[5]Arends MJ,White ES,Whitelaw CB.Animal and cellular models of human disease[J].J Pathol,2016,238(2):137-140.
[6]金济云,夏亲华.子宫内膜异位症动物模型研究进展[J].中国医药导报,2016,13(5):28-31.
[7]Yu J,Zhao L,Zhang D,et al.The effects and possible mechanisms of puerarin to treat endometriosis model rats[J].Evid Based Complement Alternat Med,2015:1-11.
[8]肖明成,曹丹,张红,等.雌激素在大鼠子宫内膜异位症模型建立中的作用[J].宁夏医学杂志,2011,33(7):582-584.
[9]Pereira FE,Almeida PR,Dias BH,et al.Development of a subcutaneous endometriosis rat model[J].Acta Cir Bras,2015,30(1):6-12.
[10]Lian YL,Cheng MJ,Zhang XX,et al.Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis[J].Mol Med Rep,2017,16(2):1920-1926.
[11]Cao Y,Ye Q,Zhuang M,et al.Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway[J].PLoS One,2017,12(11):207-213.
[12]哈春芳,肖成明,张晟宁,等.开放法大鼠子宫内膜异位症模型的建立与评价[J].山东大学学报:医学版,2011,49(1):62-66.
[13]Yuan M,Ding S,Meng T,et al.Effect of A-317491 delivered glycolipid-like polymer micelles on endometriosis pain[J].Int Nanomedicine,2017,12:8171-8183.
[14]杨萍,纳冬荃,熊亚龙,等.大鼠子宫内膜异位模型的建立与组织学观察[J].中国实验动物学报,2006,14(2):139-141.
[15]彭艳,何援利.大鼠子宫内膜异位症动物模型建立方法的比较[J].重庆医学,2012,41(25):2619-2620.
[16]王哲,路芳.逆流法建立大鼠子宫内膜异位模型[J].实用中西医结合临床,2015,15(6):3-4,32.
[17]李田田,孙伟伟,赵瑞华,等.子宫内膜异位症盆腔粘连大鼠模型的建立与评价[J].中国比较医学杂志,2017,27(12):8-15.
[18]Pinar N,Soylu Karapinar O,Ozcan O,et al.Effect of alpha-lipoic acid on endometrial implants in an experimental rat model[J].Fundam Clin Pharmacol,2017,31(5):506-512.
[19]马春燕,王振国,赵爱华,等.改良大鼠子宫内膜异位症动物模型成功率的实验研究[J].中国现代医学杂志,2013,23(35):28-32.
[20]张春斌,谈西满,罗佳滨,等.子宫内膜异位症动物模型的研究现状及进展[J].黑龙江医药科学,2008,31(3):80-81.
[21]李龙卫,王艳云,陈琦,等.提高大鼠子宫内膜异位症成功率的新方法[J].中国比较医学杂志,2016,26(3):81-85.
[22]Kiykac Altinbas S,Tapisiz OL,Cavkaytar S,et al.Is montelukast effective in regression of endometrial implants in an experimentally induced endometriosis model in rats?[J].Eur Obstet Gynecol Reprod Biol,2015,184:7-12.
[23]何嫣,曾金凤,刘玉环.子宫内膜异位症大鼠模型自体移植部位的比较[J].第二军医大学学报,2016,37(4):513-516.
[24]宫庭钰,关铮.子宫内膜异位症动物模型及其应用进展[J].国际生殖健康/计划生育杂志,2008,27(1):36-39.
[25]Erten OU,Ensari TA,Dilbaz B,et al.Vitamin C is effective for the prevention and regression of endometriotic implants in an experimentally induced rat[J].Taiwan J Obstet Gynecol,2016,55(2):251-257.
[26]Zhang H,Li J,Sun W,et al.Hyaluronic acid-modified magenetic iron oxide nanoparticles for MR imaging of surgically induced endometriosis model in rats[J].PLoS One,2014,9(4):26-32.
[27]冯雪,黄薇.子宫内膜异位症动物模型研究进展[J].中国比较医学杂志,2014,24(12):678-670.
[29]胡春萍,王志刚,季夏芸,等.大鼠子宫内膜异位症模型建立方法的比较[J].中国比较医学杂志,2009,19(10):44-46.
[30]单婧,程雯,翟东霞,等.子宫内膜异位症啮齿类动物模型研究进展[J].生殖医学杂志,2017,26(5):498-501.
[2]崔阳阳,孙伟伟,赵瑞华.子宫内膜异位症动物模型的研究进展[J].中国实验动物学报,2013,21(10):87-89.
[3]李凤英.子宫内膜异位症的临床特点及其发病机制探讨[J].医学前沿,2018,8(8):234-235.
[4]成萍,纪燕琴.子宫内膜异位症发病机制的研究进展[J].中华妇幼临床医学杂志,2015,11(1):117-119.
[5]Arends MJ,White ES,Whitelaw CB.Animal and cellular models of human disease[J].J Pathol,2016,238(2):137-140.
[6]金济云,夏亲华.子宫内膜异位症动物模型研究进展[J].中国医药导报,2016,13(5):28-31.
[7]Yu J,Zhao L,Zhang D,et al.The effects and possible mechanisms of puerarin to treat endometriosis model rats[J].Evid Based Complement Alternat Med,2015:1-11.
[8]肖明成,曹丹,张红,等.雌激素在大鼠子宫内膜异位症模型建立中的作用[J].宁夏医学杂志,2011,33(7):582-584.
[9]Pereira FE,Almeida PR,Dias BH,et al.Development of a subcutaneous endometriosis rat model[J].Acta Cir Bras,2015,30(1):6-12.
[10]Lian YL,Cheng MJ,Zhang XX,et al.Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis[J].Mol Med Rep,2017,16(2):1920-1926.
[11]Cao Y,Ye Q,Zhuang M,et al.Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway[J].PLoS One,2017,12(11):207-213.
[12]哈春芳,肖成明,张晟宁,等.开放法大鼠子宫内膜异位症模型的建立与评价[J].山东大学学报:医学版,2011,49(1):62-66.
[13]Yuan M,Ding S,Meng T,et al.Effect of A-317491 delivered glycolipid-like polymer micelles on endometriosis pain[J].Int Nanomedicine,2017,12:8171-8183.
[14]杨萍,纳冬荃,熊亚龙,等.大鼠子宫内膜异位模型的建立与组织学观察[J].中国实验动物学报,2006,14(2):139-141.
[15]彭艳,何援利.大鼠子宫内膜异位症动物模型建立方法的比较[J].重庆医学,2012,41(25):2619-2620.
[16]王哲,路芳.逆流法建立大鼠子宫内膜异位模型[J].实用中西医结合临床,2015,15(6):3-4,32.
[17]李田田,孙伟伟,赵瑞华,等.子宫内膜异位症盆腔粘连大鼠模型的建立与评价[J].中国比较医学杂志,2017,27(12):8-15.
[18]Pinar N,Soylu Karapinar O,Ozcan O,et al.Effect of alpha-lipoic acid on endometrial implants in an experimental rat model[J].Fundam Clin Pharmacol,2017,31(5):506-512.
[19]马春燕,王振国,赵爱华,等.改良大鼠子宫内膜异位症动物模型成功率的实验研究[J].中国现代医学杂志,2013,23(35):28-32.
[20]张春斌,谈西满,罗佳滨,等.子宫内膜异位症动物模型的研究现状及进展[J].黑龙江医药科学,2008,31(3):80-81.
[21]李龙卫,王艳云,陈琦,等.提高大鼠子宫内膜异位症成功率的新方法[J].中国比较医学杂志,2016,26(3):81-85.
[22]Kiykac Altinbas S,Tapisiz OL,Cavkaytar S,et al.Is montelukast effective in regression of endometrial implants in an experimentally induced endometriosis model in rats?[J].Eur Obstet Gynecol Reprod Biol,2015,184:7-12.
[23]何嫣,曾金凤,刘玉环.子宫内膜异位症大鼠模型自体移植部位的比较[J].第二军医大学学报,2016,37(4):513-516.
[24]宫庭钰,关铮.子宫内膜异位症动物模型及其应用进展[J].国际生殖健康/计划生育杂志,2008,27(1):36-39.
[25]Erten OU,Ensari TA,Dilbaz B,et al.Vitamin C is effective for the prevention and regression of endometriotic implants in an experimentally induced rat[J].Taiwan J Obstet Gynecol,2016,55(2):251-257.
[26]Zhang H,Li J,Sun W,et al.Hyaluronic acid-modified magenetic iron oxide nanoparticles for MR imaging of surgically induced endometriosis model in rats[J].PLoS One,2014,9(4):26-32.
[27]冯雪,黄薇.子宫内膜异位症动物模型研究进展[J].中国比较医学杂志,2014,24(12):678-670.
[29]胡春萍,王志刚,季夏芸,等.大鼠子宫内膜异位症模型建立方法的比较[J].中国比较医学杂志,2009,19(10):44-46.
[30]单婧,程雯,翟东霞,等.子宫内膜异位症啮齿类动物模型研究进展[J].生殖医学杂志,2017,26(5):498-501.