卡泊三醇对白癜风患者血清和皮肤组织中IL-18及IFN-γ水平的影响
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摘要
目的:探讨卡泊三醇对白癜风患者血清和皮肤组织中IL-18及IFN-γ水平的影响。方法:收集我院收治的白癜风患者122例,随机分为实验组和对照组。对照组予外用补骨脂酊治疗,实验组给予外用卡泊三醇软膏。观察并比较两组患者治疗前后皮损面积、不良反应发生情况以及血清和皮肤组织液中IL-18及IFN-γ水平的变化情况。结果:与治疗前相比,两组患者治疗后白斑皮损面积均显著缩小(P<0.05),血清及皮肤组织液IL-8与INF-γ水平均明显降低(P<0.05)。与对照组相比,实验组治疗后白斑皮损面积更小(P<0.05),血清及皮肤组织液IL-18及IFN-γ含量较低(P<0.05)。结论:卡泊三醇能够有效改善白癜风患者的临床症状,且安全性较高,值得临床推广应用,这可能与其降低白癜风患者血清及皮肤组织液中IL-18及IFN-γ水平有关。
Objective:To investigate the effect of calcipotriol on the levels of IL-18 and IFN-γ in serum and skin tissue of patients with leucoderma.Methods:122 patients with leucoderma who were treated in our hospital were selected and randomly divided into the control group and the experimental group.The patients in the control group were treated with the external vaseline,while the patients in the experimental group were treated with calcipotriol.Then the skin lesion areas,incidence of adverse reactions and levels of IL-18 and IFN-γ in serum and skin tissue of both groups were observed and compared before and after the treatment.Results:Compared with before treatment,the leukoplakia lesions areas of both groups significantly reduced(P<0.05),the levels of IL-8 and INF-γ in serum and skin tissue obviously decreased in both groups after the treatment(P<0.05).Compared with the control group,the leukoplakia lesions area were smaller in the experimental group after the treatment(P<0.05),and the levels of IL-8 and INF-γ in serum and skin tissue were lower in the experimental group(P<0.05).Conclusions:Calcipotriol could effectively improve the clinical syptom of patients with leucoderma and had high safety,which might be related to the decrease of IL-18 and IFN-γ levels in serum and skin tissue.
Objective:To investigate the effect of calcipotriol on the levels of IL-18 and IFN-γ in serum and skin tissue of patients with leucoderma.Methods:122 patients with leucoderma who were treated in our hospital were selected and randomly divided into the control group and the experimental group.The patients in the control group were treated with the external vaseline,while the patients in the experimental group were treated with calcipotriol.Then the skin lesion areas,incidence of adverse reactions and levels of IL-18 and IFN-γ in serum and skin tissue of both groups were observed and compared before and after the treatment.Results:Compared with before treatment,the leukoplakia lesions areas of both groups significantly reduced(P<0.05),the levels of IL-8 and INF-γ in serum and skin tissue obviously decreased in both groups after the treatment(P<0.05).Compared with the control group,the leukoplakia lesions area were smaller in the experimental group after the treatment(P<0.05),and the levels of IL-8 and INF-γ in serum and skin tissue were lower in the experimental group(P<0.05).Conclusions:Calcipotriol could effectively improve the clinical syptom of patients with leucoderma and had high safety,which might be related to the decrease of IL-18 and IFN-γ levels in serum and skin tissue.
引文
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[2]Liu C P,Dai C A,Chao C Y,et al.Novel proton exchange membrane based on cross linked poly(vinyl alcohol)for direct methanol fuel cells[J].Journal of Power Sources,2014,249(1):285-298
[3]Hsieh C H,Li-Ting S U,Wang Y C,et al.Does alcohol intoxication protect patients from severe injury and reduce hospital mortality?The association of alcohol consumption with the severity of injury and survival in trauma patients[J].Am Surg,2013,79(12):1289-1294
[4]Kil H S,Cho H Y,Lee S J,et al.Alternative synthesis for the preparation of 16-[(18)F]fluoroestradiol[J].Journal of Labelled Compounds,2013,56(12):619-626
[5]Wiener C.Association of smokeless tobacco use and smoking in adolescents in the United States[J].Journal of the American Dental Association,2013,144(8):930-938
[6]Morita K,Saruwatari J,Miyagawa H,et al.Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus[J].Cardiovascular Diabetology,2013,12(7):247-258
[7]Ansari W E,Sebena R,Stock C.Socio-demographic correlates of six indicators of alcohol consumption:survey findings of students across seven universities in England,Wales and Northern Ireland[J].Archives of Public Health,2013,71(1):29
[8]Quigg Z,Hughes K,Bellis M A.Student drinking patterns and blood alcohol concentration on commercially organised pub crawls in the UK[J].Addictive Behaviors,2013,38(12):2924-2929
[9]Kahler C W,Metrik J,Spillane N S,et al.Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task[J].Psychopharmacology,2014,231(24):4649-4657
[10]Borràs E,Albalat R,Duester G,et al.The Xenopus alcohol dehydrogenase gene family:characterization and comparative analysis incorporating amphibian and reptilian genomes[J].Bmc Genomics,2014,15(13):216
[11]Vorobjov S,Saat H,Kull M.Social Skills and Their Relationship to Drug Use Among 15-16-Year-Old Students in Estonia:An Analysis Based on the ESPAD Data[J].Nordic Studies on Alcohol&Drugs,2014,31(4):401-412
[12]Pon-On W,Charoenphandhu N,Teerapornpuntakit J,et al.Mechanical properties,biological activity and protein controlled release by poly(vinyl alcohol)-bioglass/chitosan-collagen composite scaffolds:a bone tissue engineering applications[J].Materials Science&Engineering C,2014,38(9):63-72
[13]Phuong T B,Huong N T,Tien T Q,et al.Factors associated with health risk behavior among school children in urban Vietnam[J].Global Health Action,2013,6(2):78-86
[14]Luu B N,Nguyen T T,Newman I M.Traditional alcohol production and use in three provinces in Vietnam:an ethnographic exploration of health benefits and risks[J].Bmc Public Health,2014,14(16):1-14
[15]Sagtani R A,Bhattarai S,Adhikari B R,et al.Alcohol use,HIV risk behavior and experience of sexually transmitted infections among female sex workers of Nepal[J].Clinical Epidemiology&Global Health,2013,1(2):73-78
[16]Gunby C,Carline A,Beynon C,et al.Regretting it After?Focus Group Perspectives on Alcohol Consumption,Nonconsensual Sex and False Allegations of Rape[J].Social&Legal Studies,2013,22(1):87-106
[17]Sarah T,Catherine L,Lauren B,et al.Longitudinal MRI reveals altered trajectory of brain development during childhood and adolescence in fetal alcohol spectrum disorders[J].Journal of Neuroscience,2013,33(24):10098-10109
[18]Abby L,Goldstein M,Breanne F,et al.The relationship among internal resilience,smoking,alcohol use,and depression symptoms in emerging adults transitioning out of child welfare[J].Child Abuse Negl,2013,37(1):22-32
[19]Farzaneh N,Ghobaklou M,Moghimi-Dehkordi B,et al.Effects of Demographic Factors,Body Mass Index,Alcohol Drinking and Smoking Habits on Irritable Bowel Syndrome:A Case Control Study[J].Annals of Medical&Health Sciences Research,2013,3(3):391-396
[20]Tonigan J S.Longitudinal Study of Urban American Indian 12-Step Attendance,Attrition,and Outcome[J].Journal of Studies on Alcohol&Drugs,2013,74(4):514-520