头孢硫脒联合阿维A胶囊对老年银屑病患者血液流变学及甲襞微循环的影响
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摘要
目的:探讨头孢硫脒联合阿维A胶囊对老年银屑病患者血液流变学及甲襞微循环的影响。方法:选取在我院确诊为银屑病的患者158例,随机分为研究组和对照组。对照组采用口服阿维A胶囊治疗,研究组在此基础上加用静脉滴注头孢硫脒,观察并比较两组患者治疗前后血液流变性变化及甲襞微循环情况。结果:与治疗前比较,两组患者的血液流变学指标如ηb、ηp、EAI、Tk值、Hct、血沉方程K值以及ESR水平均显著降低(P<0.05);微血管形态学指标如管袢清晰,畸形管袢减少,袢顶狭窄较少,输入枝血管直径增宽,输出枝血管直径变窄,管袢延长(P<0.05);血液流态指标如血流速度加快,粒流以及粒缓流状态减少,微小血栓量减少,管袢周围视野较清晰(P<0.05);加权积分降低(P<0.05)。与对照组比较,研究组治疗后血液流变学指标、微血管形态学指标、血管流态指标、加权积分均显著改善(P<0.05)。结论:头孢硫脒联合阿维A胶囊较单用阿维A胶囊可更明显改善老年银屑病患者的血液流变性变化及甲襞微循环。
To investigate the effect on the changes of Hemorheology and Nailfold Microcirculation by Antibiotics combined with Acitretin Capsules in elderly patients with psoriasis. Methods: 158 patients with psoriasis from our hospital were selected and randomly divided into the control group and the experiment group. The 76 cases in control group were treated with the oral Acitretin Capsules, while the 82 cases in experiment group were treated with the intravenous infusion of cefathiamidine on the basis of the control group. Then the changes of hemorheology and nailfold microcirculation were detected and compared. Results: Compared with before treatment, the indexes of ηb, ηp, EAI, Tk, Hct, K and ERK of two groups decreased(P< 0.05), the tube defects reduced, top stenosis decreased, input branch vessel diameter widened and output branch vascular diameter decreased(P<0.05), the morphology of the micro vessel was lower, the flow pattern of blood flow index was lower(P<0.05), and the weighted score was lower(P < 0.05). Compared with the control group, the blood rheology, micro vascular morphology, blood flow index and weighted score in the study group significantly improved after the treatment(P<0.05). Conclusion: Antibiotics combined with acitretin capsule has good therapeutic effect on the changes of hemorheology and nailfold microcirculation for elderly patients with psoriasis.
To investigate the effect on the changes of Hemorheology and Nailfold Microcirculation by Antibiotics combined with Acitretin Capsules in elderly patients with psoriasis. Methods: 158 patients with psoriasis from our hospital were selected and randomly divided into the control group and the experiment group. The 76 cases in control group were treated with the oral Acitretin Capsules, while the 82 cases in experiment group were treated with the intravenous infusion of cefathiamidine on the basis of the control group. Then the changes of hemorheology and nailfold microcirculation were detected and compared. Results: Compared with before treatment, the indexes of ηb, ηp, EAI, Tk, Hct, K and ERK of two groups decreased(P< 0.05), the tube defects reduced, top stenosis decreased, input branch vessel diameter widened and output branch vascular diameter decreased(P<0.05), the morphology of the micro vessel was lower, the flow pattern of blood flow index was lower(P<0.05), and the weighted score was lower(P < 0.05). Compared with the control group, the blood rheology, micro vascular morphology, blood flow index and weighted score in the study group significantly improved after the treatment(P<0.05). Conclusion: Antibiotics combined with acitretin capsule has good therapeutic effect on the changes of hemorheology and nailfold microcirculation for elderly patients with psoriasis.
引文
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[15]Lapresto L,Cranmer L,Morrison L,et al.A novel therapeutic combination approach for treating multiple vemurafenib-induced keratoacanthomas:systemic acitretin and intralesional fluorouracil[J].Jama Dermatol,2013,149(3):279-281
[16]Raguideau F,Mezzarobba M,Zureik M,et al.Compliance with pregnancy prevention plan recommendations in 8672 French women of childbearing potential exposed to acitretin[J].Pharmacoepidemiology&Drug Safety,2015,24(5):526-533
[17]Cengiz F P,Albayrak A.A Case of Lichen Amyloidosis Treated with Low Dose Acitretin[J].Turk Dermatoloji Dergisi,2014,8(4):240-243
[2]Cheeley J,Sahn RE,De Long LK,et al.Acitretin for the treatment of cutaneous T-cell lymphoma[J].Journal of the American Academy of Dermatology,2013,68(2):247-254
[3]Chon S Y,Sambrano B L,Geddes E R.Vemurafenib-related cutaneous side effects ameliorated by acitretin[J].Journal of Drugs in Dermatology,2014,13(5):586-588
[4]Sarma N,Ghosh C,Kar S,et al.Low-dose acitretin in PapillonLefèvre syndrome:treatment and 1-year follow-up[J].Dermatologic Therapy,2015,28(1):28-31
[5]Silva F S G,Ribeiro M P C,Santos M S,et al.Acitretin affects bioenergetics of liver mitochondria and promotes mitochondrial permeability transition:potential mechanisms of hepatotoxicity[J].Toxicology,2013,306(2):93-100
[6]Elena G,Mar L V,Esteban D,et al.Refractory generalized pustular psoriasis responsive to a combination of adalimumab and acitretin[J].International Journal of Dermatology,2013,52(12):1610-1611
[7]Ricceri F,Pescitelli L,Tripo L,et al.Treatment of severe nail psoriasis with acitretin:an impressive therapeutic result[J].Dermatologic Therapy,2013,26(1):77-78
[8]Matusiak,Bieniek A,Szepietowski J C.Acitretin treatment for hidradenitis suppurativa:a prospective series of 17 patients[J].British Journal of Dermatology,2014,171(1):170-174
[9]Wang Y H,Tsai D.Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapy[J].Dermatologica Sinica,2014,32(1):39-42
[10]Ward P D,Miller H L,Shipman A R.A case of repigmentation and curling of hair on acitretin therapy[J].Clinical&Experimental Dermatology,2014,39(1):91-92
[11]Srinivasaraghavan R,Krishnamurthy S,Chandar R,et al.Acitretin Responsive Ichthyosis in Chanarin-Dorfman Syndrome with a Novel Mutation in the ABHD5/CGI 58 Gene[J].Pediatric Dermatology,2014,31(5):612-614
[12]Alsenaid A,Lang A,Ruzicka T,et al.Lichen planus with associated myasthenia gravis-successful treatment with acitretin[J].European Journal of Dermatology,2013,23(6):909-910
[13]Silva F S G,Oliveira H,Moreiras A,et al.Cytotoxic and genotoxic effects of acitretin,alone or in combination with psoralen-ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients[J].Mutation Research fundamental&Molecular Mechanisms of Mutagenesis,2013,753(1):42-47
[14]Nijhawan R I,Osei-Tutu A,Hugh J M.Sustained clinical resolution of acquired epidermodysplasia verruciformis in an immunocompromised patient after discontinuation of oral acitretin with topical imiquimod[J].Journal of Drugs in Dermatology,2013,12(3):348-349
[15]Lapresto L,Cranmer L,Morrison L,et al.A novel therapeutic combination approach for treating multiple vemurafenib-induced keratoacanthomas:systemic acitretin and intralesional fluorouracil[J].Jama Dermatol,2013,149(3):279-281
[16]Raguideau F,Mezzarobba M,Zureik M,et al.Compliance with pregnancy prevention plan recommendations in 8672 French women of childbearing potential exposed to acitretin[J].Pharmacoepidemiology&Drug Safety,2015,24(5):526-533
[17]Cengiz F P,Albayrak A.A Case of Lichen Amyloidosis Treated with Low Dose Acitretin[J].Turk Dermatoloji Dergisi,2014,8(4):240-243