一清胶囊配合异维A酸红霉素凝胶治疗寻常痤疮临床观察
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摘要
目的观察一清胶囊配合异维A酸红霉素凝胶治疗寻常痤疮的临床疗效。方法 80例寻常痤疮患者随机分为治疗组和对照组各40例,均外用异维A酸红霉素凝胶,1次·d-1,疗程均为8周,治疗组同时加用一清胶囊。结果 8周后治疗组和对照组总有效率分别为77.50%和55.00%,疗效差异有统计学意义(P=0.033)。结论一清胶囊配合异维A酸红霉素凝胶治疗寻常痤疮临床疗效确切,优于单用异维A酸红霉素凝胶治疗。
Objective To observe the clinical effect of isotretinoin erythromycin gel combined with Yiqing Capsules on acne vulgaris.Method 80 patients with acne vulgaris were randomly divided into treatment group(n=40)and control group(n=40).The two groups patients were given isotretinoin erythromycin gel for external use,once a day.The course of treatment was 8 weeks.While the treatment group were given Yiqing Capsules additionally.Results After 8-week treatment,the effective rates of the treatment group and the control group were 77.50% and 55.00% respectively.There was significant difference between two groups(P=0.033).Conclusion The efficacy of isotretinoin erythromycin gel combined with Yiqing Capsules in acne vulgaris is better.
Objective To observe the clinical effect of isotretinoin erythromycin gel combined with Yiqing Capsules on acne vulgaris.Method 80 patients with acne vulgaris were randomly divided into treatment group(n=40)and control group(n=40).The two groups patients were given isotretinoin erythromycin gel for external use,once a day.The course of treatment was 8 weeks.While the treatment group were given Yiqing Capsules additionally.Results After 8-week treatment,the effective rates of the treatment group and the control group were 77.50% and 55.00% respectively.There was significant difference between two groups(P=0.033).Conclusion The efficacy of isotretinoin erythromycin gel combined with Yiqing Capsules in acne vulgaris is better.
引文
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[20]王宝庭.一清胶囊联合盐酸多西环素胶囊治疗痤疮疗效观察[J].中国皮肤性病学杂志,2011,25(5):406-407.
[2]赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2010:1165-1169.
[3]靳培英.痤疮的分型论治[J].中华皮肤科杂志,2007,35(1):67-69.
[4]DEGITZ K,PLAEZEK M,BOREUI C,et al.Pathophysiology of acne[J].Dtsch Dermatol Ges,2007,5(4):316-323.
[5]张学军.皮肤性病学[M].北京:人民卫生出版社,2001:144-145.
[6]朱学骏,顾有守,沈丽玉.实用皮肤病性病治疗学[M].北京:北京医科大学、中国协和医科大学联合出版社,1998:404-407.
[7]THIBOUTOT D,GOLLNICK H,BETTOLI V,et al.New insights into the management of acne:an update from the global alliance to improve outcomes in acne group[J].Am Acad Dermatol,2009,60(5Suppl):S1-S50.
[8]BERSHAD S,ANJAC S G,PARENTE J E,et al.Successful treatment of acnc vulgaris using a new method:results of a random ized vehicle.controlled trial of short.contact therapy with 0.1%tazarotenegel[J].Arch Dermatol,2002,138:481-489.
[9]马春红,李东影,王仁章,等.红霉素类抗生素分析研究进展[J].长春师范学院学报(自然科学版),2008,17(8):72-76.
[10]张国强,王文氢,康瑞花,等.异维A酸红霉素凝胶治疗轻、中度寻常性痤疮临床观察[J].中国皮肤性病学杂志,2011,25(5):368-369.
[11]刘盛秀,杨春俊,杨森,等.异维A酸红霉素凝胶治疗寻常型痤疮临床观察[J].中国美容医学,2010,19(9):1348-1350.
[12]丁虹.一清胶囊佐治上呼吸道感染的疗效观察[J].辽宁中医学院学报,2005,7(6):593.
[13]张向红,程黎晖.大黄的药理作用及临床应用研究进展[J].中国药业,2009,18(21):76.
[14]刘旭海.大黄药理作用及临床应用研究进展[J].山东高等专科学校学报,2007,29(3):2291.
[15]刘云波,郭丽华,邱世翠,等.黄芩体外抑菌作用研究[J].时珍国医国药,2002,13(10):187.
[16]战渤玉,高明,李东霞,等.中药材黄芩的研究进展[J].中医药信息,2008,25(6):161.
[17]邱世翠,荣先国,邸大琳,等.黄连的体外抑菌作用研究[J].时珍国医国药,2002,13(4):196.
[18]余园媛,王伯初,彭亮,等.黄连的药理研究进展[J].重庆大学学报,2006,29(2):1071.
[19]冯国强.一清胶囊治疗328例痤疮的临床观察[J].华西医学杂志,2001(1):61.
[20]王宝庭.一清胶囊联合盐酸多西环素胶囊治疗痤疮疗效观察[J].中国皮肤性病学杂志,2011,25(5):406-407.