加味黑布膏联合IPL治疗痤疮瘢痕的临床观察
|
摘要
目的探讨加味黑布膏联合强脉冲光(IPL)治疗痤疮瘢痕的临床疗效。方法将本院收治的76例面部痤疮瘢痕患者随机分为对照组与治疗组,每组各38例,对照组单纯采用IPL治疗,治疗组采用加味黑布膏联合IPL治疗,治疗后对比两组临床疗效。结果两组治疗前后皮损积分差值比较差异有统计学意义(P<0.001),治疗组皮损改善程度优于对照组;两组有效率比较差异有统计学意义(P<0.001),治疗组有效率(94.59%)高于对照组有效率(72.22%);对照组、治疗组不良反应发生率分别为13.88%和2.70%,二者差异无统计学意义(P>0.05),两组的不良反应均轻微,可耐受。结论加味黑布膏联合IPL治疗痤疮瘢痕具有较好的疗效,临床参考价值较高。
Objective To explore the clinical efficacy of modified heibu ointment combined with intense pulsed light( IPL) in the treatment of acne scars. Methods In the 76 cases of facial acne scar treated by our hospital,the patients randomly divided into control group and treatment group,38 cases per group. The control group was treated with IPL alone,the treatment group was treated with a combination of modified heibu ointment and IPL. After treatment,two groups of clinical efficacy and patient satisfaction were compared. Results The difference of integral of skin lesions between the two groups before and after treatment was statistically significant( P<0. 001),the improvement of skin lesion in the treatment group was better than that of the control group.The difference between the two groups was statistically significant( P<0. 001),the effective rate of the treatment group( 94. 59%) was higher than that of the control group( 72. 22%). The incidence of adverse reactions in the control group and the treatmentgroup was 13. 88% and 2. 70%,there was not statistically difference( P > 0. 05). Adverse reactions in both groups were mild and tolerable. Conclusion The combination of modified heibu ointment and IPL is more effective for acne scars,the clinical reference value is higher.
Objective To explore the clinical efficacy of modified heibu ointment combined with intense pulsed light( IPL) in the treatment of acne scars. Methods In the 76 cases of facial acne scar treated by our hospital,the patients randomly divided into control group and treatment group,38 cases per group. The control group was treated with IPL alone,the treatment group was treated with a combination of modified heibu ointment and IPL. After treatment,two groups of clinical efficacy and patient satisfaction were compared. Results The difference of integral of skin lesions between the two groups before and after treatment was statistically significant( P<0. 001),the improvement of skin lesion in the treatment group was better than that of the control group.The difference between the two groups was statistically significant( P<0. 001),the effective rate of the treatment group( 94. 59%) was higher than that of the control group( 72. 22%). The incidence of adverse reactions in the control group and the treatmentgroup was 13. 88% and 2. 70%,there was not statistically difference( P > 0. 05). Adverse reactions in both groups were mild and tolerable. Conclusion The combination of modified heibu ointment and IPL is more effective for acne scars,the clinical reference value is higher.
引文
[1]张学军.皮肤性病学[M].8版.北京:人民卫生出版社,2013:175.
[2]曹林,席庆春,李旋.强脉冲光联合点阵铒激光治疗痤疮瘢痕疗效分析[J].系统医学,2017,2(10):89-92.
[3]Rivera AE.Acne scarring:a review and current treatment modalities[J].J Am Acad Dermatol,2008,59(4):659-676.
[4]张国强,王文氢,康瑞花,等.异维A酸红霉素凝胶治疗轻、中度寻常性痤疮临床观察[J].中国皮肤性病学杂志,2011,25(5):368-369.
[5]李国艳,于潮,陈亚会,等.丹参酮联合米诺环素治疗中、重度痤疮35例临床观察[J].中国皮肤性病学杂志,2017,31(2):235-236.
[6]张江安,于建斌.银屑胶囊联合阿维A胶囊治疗寻常性银屑病的临床观察[J].中国皮肤性病学杂志,2012,26(3):279-280.
[7]张胜正,胡倩婷.强脉冲光联合595nm脉冲染料激光治疗痤疮后色素沉着和瘢痕的临床疗效[J].中国激光医学杂志,2014,23(4):203-206.
[8]莫仲莲,钟山,马丹晓,等.强脉冲光联合外用药物治疗寻常型痤疮的临床研究[J].现代医院,2012,12(4):6-8.
[9]王磊.黑布膏治疗瘢痕的临床疗效观察[J].黑龙江医药,2010,23(4):626-627.
[10]崔莉,朱金土,王雅飞.中医药联合IPL治疗痤疮127例[J].陕西中医学院学报,2014,37(1):53-58.
[11]吴利荣,胡晓继,李少荣,等.二氧化碳点阵激光联合硅酮凝胶治疗剖宫产皮肤瘢痕的疗效分析[J].安徽医药,2016,20(3):559-562.
[12]陆洁,何梅.超脉冲CO2点阵激光与微针治疗痤疮凹陷性瘢痕的疗效评价[J].西部医学,2015,27(11):1660-1662.
[13]叶霞,叶培,骆焕,等.超脉冲CO2点阵激光联合胶原贴敷料治疗面部痤疮瘢痕的效果观察[J].保健医学研究与实践,2017,14(3):77-78.
[14]郑筱萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:292.
[15]肖洁平,万建勣,丁街生,等.Er:YAG点阵激光治疗面部凹陷性痤疮瘢痕30例疗效观察[J].中国美容医学杂志,2015,24(12):50-53.
[16]马虎,余先华,张朝霞.红蓝光联合维胺脂等治疗中重度痤疮115例临床观察[J].中国皮肤性病学杂志,2015,29(1):104-106.
[17]常梦玲,马晓荣,欧阳天祥.局部5-氨基酮戊酸光动力疗法治疗增生性瘢痕的进展[J].中国美容医学杂志,2014,23(10):857-860.
[18]姜嵩,张艺琼,陈媛,等.超脉冲CO2点阵激光联合针刺疗法治疗痤疮凹陷性瘢痕的自身对照观察[J].中国皮肤性病学杂志,2017,31(8):912-915.
[19]刘叶兰.中医对寻常痤疮病因病机的认识[J].河南中医,2006,26(4):6-8.
[20]Negishi K,Wakamatsu S,Kushikata N,et al.Full-face photore-juvenation of photodamaged skin by intense pulsed light with inte-grated contact cooling:initial experiences in A-sian patients[J].Lasers Surg Med,2002,30(4):298-305.
[21]相恒芳,刘正,张蕾,等.强脉冲光(IPL)联合5%过氧苯甲酰凝胶治疗面部痤疮的临床疗效观察[J].当代医学,2017,23(24):47-49.
[22]马琼,孙素姣,王燕,等.强脉冲光联合医学护肤品治疗面部寻常型痤疮临床观察[J].中国美容医学杂志,2011,20(1):100-102.
[23]李治军,韩海虹.加味黑布膏治疗增生性瘢痕52例[J].中医学报,2002,18(3):72-73.
[24]黄卫平,陶革方,陈瑾,等.手术联合术后放疗及中药外敷治疗瘢痕疙瘩59例疗效分析[J].中国中西医结合皮肤性病学杂志,2010,9(5):321-322.
[25]王磊.黑布膏治疗瘢痕的临床疗效观察[J].黑龙江医药,2010,23(4):626-627.
[2]曹林,席庆春,李旋.强脉冲光联合点阵铒激光治疗痤疮瘢痕疗效分析[J].系统医学,2017,2(10):89-92.
[3]Rivera AE.Acne scarring:a review and current treatment modalities[J].J Am Acad Dermatol,2008,59(4):659-676.
[4]张国强,王文氢,康瑞花,等.异维A酸红霉素凝胶治疗轻、中度寻常性痤疮临床观察[J].中国皮肤性病学杂志,2011,25(5):368-369.
[5]李国艳,于潮,陈亚会,等.丹参酮联合米诺环素治疗中、重度痤疮35例临床观察[J].中国皮肤性病学杂志,2017,31(2):235-236.
[6]张江安,于建斌.银屑胶囊联合阿维A胶囊治疗寻常性银屑病的临床观察[J].中国皮肤性病学杂志,2012,26(3):279-280.
[7]张胜正,胡倩婷.强脉冲光联合595nm脉冲染料激光治疗痤疮后色素沉着和瘢痕的临床疗效[J].中国激光医学杂志,2014,23(4):203-206.
[8]莫仲莲,钟山,马丹晓,等.强脉冲光联合外用药物治疗寻常型痤疮的临床研究[J].现代医院,2012,12(4):6-8.
[9]王磊.黑布膏治疗瘢痕的临床疗效观察[J].黑龙江医药,2010,23(4):626-627.
[10]崔莉,朱金土,王雅飞.中医药联合IPL治疗痤疮127例[J].陕西中医学院学报,2014,37(1):53-58.
[11]吴利荣,胡晓继,李少荣,等.二氧化碳点阵激光联合硅酮凝胶治疗剖宫产皮肤瘢痕的疗效分析[J].安徽医药,2016,20(3):559-562.
[12]陆洁,何梅.超脉冲CO2点阵激光与微针治疗痤疮凹陷性瘢痕的疗效评价[J].西部医学,2015,27(11):1660-1662.
[13]叶霞,叶培,骆焕,等.超脉冲CO2点阵激光联合胶原贴敷料治疗面部痤疮瘢痕的效果观察[J].保健医学研究与实践,2017,14(3):77-78.
[14]郑筱萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:292.
[15]肖洁平,万建勣,丁街生,等.Er:YAG点阵激光治疗面部凹陷性痤疮瘢痕30例疗效观察[J].中国美容医学杂志,2015,24(12):50-53.
[16]马虎,余先华,张朝霞.红蓝光联合维胺脂等治疗中重度痤疮115例临床观察[J].中国皮肤性病学杂志,2015,29(1):104-106.
[17]常梦玲,马晓荣,欧阳天祥.局部5-氨基酮戊酸光动力疗法治疗增生性瘢痕的进展[J].中国美容医学杂志,2014,23(10):857-860.
[18]姜嵩,张艺琼,陈媛,等.超脉冲CO2点阵激光联合针刺疗法治疗痤疮凹陷性瘢痕的自身对照观察[J].中国皮肤性病学杂志,2017,31(8):912-915.
[19]刘叶兰.中医对寻常痤疮病因病机的认识[J].河南中医,2006,26(4):6-8.
[20]Negishi K,Wakamatsu S,Kushikata N,et al.Full-face photore-juvenation of photodamaged skin by intense pulsed light with inte-grated contact cooling:initial experiences in A-sian patients[J].Lasers Surg Med,2002,30(4):298-305.
[21]相恒芳,刘正,张蕾,等.强脉冲光(IPL)联合5%过氧苯甲酰凝胶治疗面部痤疮的临床疗效观察[J].当代医学,2017,23(24):47-49.
[22]马琼,孙素姣,王燕,等.强脉冲光联合医学护肤品治疗面部寻常型痤疮临床观察[J].中国美容医学杂志,2011,20(1):100-102.
[23]李治军,韩海虹.加味黑布膏治疗增生性瘢痕52例[J].中医学报,2002,18(3):72-73.
[24]黄卫平,陶革方,陈瑾,等.手术联合术后放疗及中药外敷治疗瘢痕疙瘩59例疗效分析[J].中国中西医结合皮肤性病学杂志,2010,9(5):321-322.
[25]王磊.黑布膏治疗瘢痕的临床疗效观察[J].黑龙江医药,2010,23(4):626-627.