鼻部巨大型角化棘皮瘤
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摘要
报告1例鼻部巨大型角化棘皮瘤。患者男,45岁。因鼻部包块3个月。无痛痒,曾在当地医院行手术切除,组织病理诊断为角化棘皮瘤。术后10余天于手术部位再次出现新生肿物,并逐渐增大至鸡蛋大,我院皮损组织病理检查:表皮增生,角化过度,伴有角栓形成及角囊肿形成,表皮突不规则延伸,呈假上皮瘤样增生,真皮见以淋巴细胞、浆细胞为主的炎性细胞浸润,伴局灶性异物肉芽肿形成。诊断:鼻部巨大型角化棘皮瘤。转上级医院手术切除。
A case of giant nasal keratoacanthoma is reported. A 45-year-old man presented with a mass over his nose for3 months. The mass was surgically removed in a local hospital. Histopathological diagnosis was keratoacanthoma. About 10 days after the surgery, a new tumor appeared again in the surgical site, and gradually increased to the egg size. Histopathological examination showed epidermal hyperplasia and hyperkeratosis, accompanied by horn plug and horn cyst formation. Irregular extension of rete ridges appeared as pseudoepitheliomatous hyperplasia. Infiltrates of lymphocytes and plasma cells,and formation of focal foreign body granuloma were observed in the dermis. Diagnosis: Giant nasal keratoacanthoma. The patient was transferred to a higher level hospital for surgical resection.
A case of giant nasal keratoacanthoma is reported. A 45-year-old man presented with a mass over his nose for3 months. The mass was surgically removed in a local hospital. Histopathological diagnosis was keratoacanthoma. About 10 days after the surgery, a new tumor appeared again in the surgical site, and gradually increased to the egg size. Histopathological examination showed epidermal hyperplasia and hyperkeratosis, accompanied by horn plug and horn cyst formation. Irregular extension of rete ridges appeared as pseudoepitheliomatous hyperplasia. Infiltrates of lymphocytes and plasma cells,and formation of focal foreign body granuloma were observed in the dermis. Diagnosis: Giant nasal keratoacanthoma. The patient was transferred to a higher level hospital for surgical resection.
引文
[1]刘冰梅,程雪,邢荣贵,等.角化棘皮瘤消退机制的研究进展[J].实用肿瘤学杂志,2017,31(1):83-87.
[2]崔瑜,王文氢,胡彩霞.前胸巨大角化棘皮瘤l例[J].中国皮肤性病学杂志,2014,28(9):847.
[3] Slater M, Barden JA. Differentiating keratoacanthoma from squamous cell carcinoma by the use of apoptotic and cell adhesion markers[J]. Histopathology, 2005, 47(2):170-178.
[4]程校衔,李舒丽,戴维,等.角化棘皮瘤144例临床及组织病理分析[J].临床皮肤科杂志,2015,44(8):473-476.
[5]李颂,涂平,朱学骏.角化棘皮瘤一例[J].中华皮肤科杂志,2003,36(10):607.
[6] Farias MM, Hasson A, Navarrete C, et al. Efficacy of topical photodynamic therapy for keratoacanthomas:a case-series of four patients[J]. Indian J Dermatol Venereol Leprol, 2012, 78(2):172-174.
[7]许丽娟,常建民,郑玲玲,等.单发型角化棘皮瘤57例临床及组织病理分析[J].临床皮肤科杂志,2013,42(8):451-453.
[2]崔瑜,王文氢,胡彩霞.前胸巨大角化棘皮瘤l例[J].中国皮肤性病学杂志,2014,28(9):847.
[3] Slater M, Barden JA. Differentiating keratoacanthoma from squamous cell carcinoma by the use of apoptotic and cell adhesion markers[J]. Histopathology, 2005, 47(2):170-178.
[4]程校衔,李舒丽,戴维,等.角化棘皮瘤144例临床及组织病理分析[J].临床皮肤科杂志,2015,44(8):473-476.
[5]李颂,涂平,朱学骏.角化棘皮瘤一例[J].中华皮肤科杂志,2003,36(10):607.
[6] Farias MM, Hasson A, Navarrete C, et al. Efficacy of topical photodynamic therapy for keratoacanthomas:a case-series of four patients[J]. Indian J Dermatol Venereol Leprol, 2012, 78(2):172-174.
[7]许丽娟,常建民,郑玲玲,等.单发型角化棘皮瘤57例临床及组织病理分析[J].临床皮肤科杂志,2013,42(8):451-453.