H型高血压患者同型半胱氨酸水平与颈动脉内膜厚度的研究
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摘要
目的探讨H型高血压患者血液半胱氨酸水平(HCY)与颈动脉内膜厚度的相关性。方法选取2017.3~2018.3高血压患者60例,按照血液半胱氨酸水平分为H型高血压组(HCY≧10 umol/l)与普通组(HCY<10 umol/l),所选受试者入院后常规抽血化验血糖,血脂,肾功能,同型半胱氨酸,采用彩色多普勒超生测定颈动脉内膜厚度(CIMT),进而分析HCY水平与CIMT的关系。结果 H型高血压组较普通组患者颈动脉内膜厚度增加,且随着HCY值增加,IMT值也相应的增加。组间比较差异有统计学意义(P<0.05)。结论 H型高血压患者相比较与一般高血压患者更容易发生颈动脉硬化,且HCY可作为颈动脉硬化的预测因子。
Objective To investigate the correlation between blood cysteine level(HCY) and carotid artery intima thickness in patients with type H hypertension.Methods Selecting between July and December 60 cases of patients with hypertension,according to blood homocysteine level is divided into H type hypertension group(HCY = 10 umol/l) and normal group(HCY<10 umol/l), selected routine blood glucose, blood test subjects after admission, renal function,blood lipid,homocysteine, carotid artery intima-media thickness measured by color Doppler bounce(CIMT), and analyze the relationship between HCY level and CIMT.Results The thickness of carotid artery intima was increased in H type hypertension group, and the value of IMT increased with the increase of HCY value. The difference between groups was statistically significant(P<0.05).Conclusion Patients with H hypertension are more likely to have carotid atherosclerosis than those with general hypertension,and HCY can be used as a predictor of carotid atherosclerosis.
Objective To investigate the correlation between blood cysteine level(HCY) and carotid artery intima thickness in patients with type H hypertension.Methods Selecting between July and December 60 cases of patients with hypertension,according to blood homocysteine level is divided into H type hypertension group(HCY = 10 umol/l) and normal group(HCY<10 umol/l), selected routine blood glucose, blood test subjects after admission, renal function,blood lipid,homocysteine, carotid artery intima-media thickness measured by color Doppler bounce(CIMT), and analyze the relationship between HCY level and CIMT.Results The thickness of carotid artery intima was increased in H type hypertension group, and the value of IMT increased with the increase of HCY value. The difference between groups was statistically significant(P<0.05).Conclusion Patients with H hypertension are more likely to have carotid atherosclerosis than those with general hypertension,and HCY can be used as a predictor of carotid atherosclerosis.
引文
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[4]侯丹丹,孙学明,王伟.血清同型半胱氨酸水平与颈动脉粥样硬化及脑梗死关系的临床研究[J].临床和实验医学,2013,5(12):334-336.
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[8]华敏,郝冬琳,沈华超,等.同型半胱氨酸血症与脑卒中的关系分析[J].中国实用神经疾病杂志,2013,16(22):70-71.
[9]甄攀攀,蒋东桥,王雯.高同型半胱氨酸血症与血管内皮细胞凋亡[J].中华老年心脑血管病杂志,2012,12(7):655-657.
[2]胡大一,徐希平.有效控制“H型”高血压—预防卒中的新思路[J].中华内科杂志,2008,47(12):976-977.
[3]王文苑.高血压病患者颈动脉内膜中层增厚危险因素分析[J].南通大学学报(医学版),2014,34(6):575-576.
[4]侯丹丹,孙学明,王伟.血清同型半胱氨酸水平与颈动脉粥样硬化及脑梗死关系的临床研究[J].临床和实验医学,2013,5(12):334-336.
[5]Catena C,Colussi G,Url-Michitsch M,et al.Subclinical carotid ar-tery disease and plasma homocysteine levels in patients with hyper-tension[J].J Am Soc Hypertens,2015.
[6]Held C,Sumner G,Sheridan P,et al.Correlations between plasma ho-mocysteine and folate concentrations and carotid atherosclerosis in high-risk individuals:baseline data from the Homocysteine and Atherosclerosis Reduction Trial(HART)[J].Vascular Medicine,2008,4(13):245-253..
[7]叶涛.同型半胱氨酸与心血管疾病的研究进展[J].实用心脑肺血管病杂志,2012,20(6):944-945.
[8]华敏,郝冬琳,沈华超,等.同型半胱氨酸血症与脑卒中的关系分析[J].中国实用神经疾病杂志,2013,16(22):70-71.
[9]甄攀攀,蒋东桥,王雯.高同型半胱氨酸血症与血管内皮细胞凋亡[J].中华老年心脑血管病杂志,2012,12(7):655-657.