低密度聚乙烯薄膜中芥酸酰胺的检测及其向食品模拟物的迁移
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摘要
采用气相色谱-质谱联用法(GC-MS)对3种低密度聚乙烯薄膜中的芥酸酰胺进行检测,研究了芥酸酰胺向食品模拟物的迁移。用毒理学关注阈值(TTC)法对芥酸酰胺的风险性进行评估。结果表明,芥酸酰胺在质量浓度为100～5 000μg/L的范围内线性良好,相关系数(R)为0.993,加标回收率为78.3%～115.6%,相对标准偏差为2.9%～11.6%,芥酸酰胺的检出限为30μg/L;在一定范围内,随着时间、温度及芥酸酰胺添加浓度的增加,芥酸酰胺的迁移量不断增加;芥酸酰胺在低密度聚乙烯和食品模拟物之间的分配系数随着芥酸酰胺的添加浓度增加而有所增加,但变化不大。
The contents of erucamide in three types of low-density polyethylene(PE-LD) films were detected by gas chromatography-mass spectrometry(GC-MS),and the migration of erucamide from PE-LD films to a simulant food was investigated. The threshold of toxicological concern(TTC) was also used to assess the safety of erucamide in foods. The results indicated that the erucamide standard curve presented a good linear relationship(R=0. 999 3) in the range of 100～5 000 μg/L. The limit of detection of erucamide was 30 μg/L, the recovery were in the range of78. 3 %～115. 6 % with a RSD of 2. 9 %～11. 6%. The migration of erucamide increased with the increase of time,temperature and erucamide concentration in the certain range. The partition coefficient of erucamide between PE-LD and simulant foods increased slightly with the increase of erucamide concentration in PE-LD.
The contents of erucamide in three types of low-density polyethylene(PE-LD) films were detected by gas chromatography-mass spectrometry(GC-MS),and the migration of erucamide from PE-LD films to a simulant food was investigated. The threshold of toxicological concern(TTC) was also used to assess the safety of erucamide in foods. The results indicated that the erucamide standard curve presented a good linear relationship(R=0. 999 3) in the range of 100～5 000 μg/L. The limit of detection of erucamide was 30 μg/L, the recovery were in the range of78. 3 %～115. 6 % with a RSD of 2. 9 %～11. 6%. The migration of erucamide increased with the increase of time,temperature and erucamide concentration in the certain range. The partition coefficient of erucamide between PE-LD and simulant foods increased slightly with the increase of erucamide concentration in PE-LD.
引文
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[23]郑明岚,周少英,刘学军,等.毒理学关注阈值(TTC)在化学物质风险评估中的应用[J].卫生研究,2010(5):639-642.ZHENG M L,ZHOU S Y,LIU X J,et al.Use of Threshold of Toxicological Concern for Chemical Substances Safety Assessment[J].Journal of Hygiene Research,2010(5):639-642.
[24]高松.纸包装油墨中增塑剂的迁移研究[D].无锡:江南大学,2014.
[2]常旭升,王恒元,周宇工,等.聚烯烃薄膜抗粘连母料的研制及应用[J].齐鲁石油化工,2003(2):87-89.CHANG X S,WANG H Y,ZHOU Y G,et al.Research of Sulphur in Du pont Dry-Spinning Acrylic Fiber Polymer[J].Qilu Petrochemical Technology,2003(2):87-89.
[3]WAKABAYASHI M,KOHNO T,TANAKA Y,et al.Study on the Bleeding Mechanism of Slip Agents in a Polypropylene Film using Molecular Dynamics[J].International Polymer Processing,2009,24(2):133-139.
[4]曹胜先,吕红丽,汪涵.新型开口爽滑剂母料在聚烯烃薄膜中的应用[J].塑料科技,2009(3):59-63.CAO S X,LU H L,WANG H.Application of New-type Anti-blocking and Slip Masterbatch in Polyolefin Film[J].Plastics Science and Technology,2009(3):59-63.
[5]任晓兵.开口爽滑剂在低密度聚乙烯薄膜中的应用[J].当代化工,2017(1):173-176.REN X B.Application of Anti-Blocking and Slip Additives in LDPE Film[J].Contemporary Chemical Industry,2017(1):173-176.
[6]MOREIRA J F M,ALVES T S,BARBOSA R,et al.Effect of Cis-13-docosenamide in the Properties of Compatibilized Polypropylene/Clay Nanocomposites[J].Macromolecular Symposia,2016,367(1):68-75.
[7]BIBRA WORKING GROUP.Erucamide[EB/OL].https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~pfcep3:3:@od@@/cgi-bin/sis/search2/d?./temp/~CEIs1H:0@.2001.
[8]房宁,王子剑,赵劲松,等.气相色谱-质谱法测定食品接触材料润滑剂在脂类食品模拟物中迁移量[J].中国食品卫生杂志,2016(3):319-322.FANG N,WANG Z J,ZHAO J S,et al.Determination of Lubricant Migration from Food Contact Materials to the Liquid Food Simulant by Chroatography-Mass Spectrometry[J].Chinese Journal of Food Hygiene,2016(3):319-322.
[9]房宁,巩俐彤,李倩,等.气相色谱-质谱法测定食品接触材料中4种润滑剂的迁移量[J].中国食品卫生杂志,2014(6):562-565.FANG N,GONG L T,LI Q,et al.Determination of 4Kinds of Migration of Lubricant in Food Contact Materials by Gas Chromatography-Mass Spectrometry[J].Chinese Journal of Food Hygiene,2014(6):562-565.
[10]郝萍,王海,韩晓昱,等.用气相色谱法测定高密度聚乙烯中爽滑剂芥酸酰胺的含量[J].石化技术与应用,2013(1):71-73.HAO P,WANG H,HAN X Y,et al.Determination of Content of Slipping Agent Erucic Amide in High Density Polyethylene by Gas Chromatography[J].Petrochemical Technology Application,2013(1):71-73.
[11]焦艳娜,丁利,肖家勇,等.气相色谱-质谱法同时测定塑料包装材料中多种有毒有害物质[J].食品安全质量检测学报,2013(4):981-987.JIAO Y N,DING L,XIAO J Y,e tal.Simultaneous Determination of Multiple Harmful Substances in Food Plastic Packing Materials by Gas Chromatography-mass Spectrometry[J].Food Safety and Quality Detection Technology,2013(4):981-987.
[12]王宽强,贺承启,张勋龙,等.气相色谱质谱联用法分析~(60)Coγ对包装材料双向拉伸尼龙/流延聚丙烯(BOPA/CPP)的辐解行为的影响[J].福建分析测试,2015(3):1-5.WANG K Q,HE C Q,ZHANG X L,et al.The Research on Effect of 60CoγIrradiation on Radiolysis Behavior of BOPA/CPP Packaging Materials by GC/MS[J].Fujian Analysis&Testing,2015(3):1-5.
[13]王莉媛.气相色谱-质谱法对粉质化妆品检验研究[J].广东化工,2015(23):52-53.WANG L Y.A Research on Testing Silty Cosmetics by Gas Chromatographic-Mass Spectrometric Method[J].Guangdong Chemical Industry,2015(23):52-53.
[14]于文涛,金明杰,李艳,等.GC-MS直接测定芥酸酰胺[J].分析试验室,2009(2):120-122.YU W T,JIN M J,LI Y,et al.Determination of Erucic Amide by Gas Chromatography-mass Spectromrtry[J].Chinese Journal of Analysis Laboratory,2009(2):120-122.
[15]薄艳娜,林勤保,吴恩玉,等.纳米银-聚乙烯复合膜中4种添加剂的检测[J].包装学报,2017(2):1-6.BO Y N,LIN Q B,WU E Y,et al.Determination of 4Additives in Polyethylene-Silver Nanocomposites Film[J].Packaging Journal,2017(2):1-6.
[16]食品安全国家标准食品接触材料及制品迁移试验通则-1:GB 31604.1-2015[S].北京:中国标准出版社,2015.
[17]张明,林勤保,单利君,等.石墨烯/低密度聚乙烯复合包装膜中两种抗氧化剂向食品模拟物异辛烷的迁移研究[J].食品科学,2017(20):209-214.ZHANG M,LIN Q B,SHAN L J,et al.Migration of Two Antioxidants from GARAPHENE/Low Density Polyethylene Composite Food Packaging Films to Food Simulants[J].Food Science,2017(20):209-214.
[18]KAREN A B,SINCLAIR R C,WATSON H D,等.食品接触材料及其化学迁移[M].宋欢,等,译.北京:中国轻工业出版社,2011:124-125.
[19]赵威威.塑料包装材料中化学物向脂肪类食品的迁移研究[D].无锡:江南大学,2007.
[20]田宇苏,陈家琪.食品包装PET中乙醛的迁移行为研究[J].中国塑料,2014,28(5):97-101.TIAN Y S,CHEN J Q.Study on Migration Behavior of Acetaldehyde from PET Bottles[J].China Plastics,2014,28(5):97-101.
[21]杨岳平,胡长鹰,李克亚,等.毒理学关注阈值方法在食品接触材料风险评估中的应用[J].食品科学,2015(23):334-339.YANG Y P,HU C Y,LI K Y,et al.Threshold of Toxicological Concern Approach for the Risk Assessment of Subtances in Food Contact Materials[J].Food Science,2015(23):334-339.
[22]隋海霞,张磊,毛伟峰,等.毒理学关注阈值方法的建立及其在食品接触材料评估中的应用[J].中国食品卫生杂志,2012(2):109-113.SUI H X,ZHANG L,MAO W F,et al.Establishment of the Threshold of Toxicological Concern with Decision Tree Approach and Its Application its Application in Food Contact Materials[J].Chinese Journal of Food Hygiene,2012(2):109-113.
[23]郑明岚,周少英,刘学军,等.毒理学关注阈值(TTC)在化学物质风险评估中的应用[J].卫生研究,2010(5):639-642.ZHENG M L,ZHOU S Y,LIU X J,et al.Use of Threshold of Toxicological Concern for Chemical Substances Safety Assessment[J].Journal of Hygiene Research,2010(5):639-642.
[24]高松.纸包装油墨中增塑剂的迁移研究[D].无锡:江南大学,2014.