上海嘉定区甲状腺癌的相关危险因素研究
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摘要
目的 :研究上海嘉定区甲状腺癌的相关危险因素,为甲状腺癌的防治提供依据。方法 :以2007年1月1日至2016年12月30日被确诊的140例上海嘉定区甲状腺癌患者为病例组,其中男性42例,女性98例,平均年龄(48.54±12.88)岁。按1:1配对招募140例非甲状腺癌对象作为对照组,其中男性42例,女性98例,平均年龄(47.11±12.58)岁。采用自行设计问卷进行统一调查。结果 :单因素分析结果显示,病例组和对照组在体重指数、口味、食用海洋动物性食品、食用腌制食品、做菜放盐顺序、处事态度、性格、婚姻生活情况、经常熬夜、饮茶、爱生闷气、有肿瘤家族史方面的差异有统计学意义(P <0.05)。COX回归分析发现口味重、爱生闷气、肿瘤家族史是甲状腺癌的危险因素。结论:肿瘤家族史、口味重、爱生闷气是与甲状腺癌独立相关,需通过健康宣教让人们更多地关注甲状腺癌,避免相关危险因素的暴露。
Objective: To study the risk factors related to thyroid cancer in Jiading District, Shanghai for providing evidence for the prevention and treatment of thyroid cancer. Methods: A total of 140 confirmed cases of thyroid cancer in Jiading District, Shanghai, from January 1, 2007 to December 30, 2016 were as a case group, including 42 males and 98 females, with an average age of(48.54±12.88) years. According to 1:1 matching, 140 cases of non thyroid cancer were recruited as a control group, including 42 males and 98 females, with an average age of(47.11±12.58) years old. A self-designed questionnaire was used to conduct the unified survey. Results: Univariate analysis results showed that there were statistically significant differences in body mass index, taste, edible marine animal food, edible preserved food, cooking and salting order, attitude, personality, marriage and life, staying up late, drinking tea, sulking and the family history of tumors between the case group and the control group(P<0.05). COX regression analysis showed that heavy taste, depression and family history of tumors were risk factors for thyroid cancer. Conclusion: Family history of tumors, heavy taste and love sulking are independent correlation of thyroid cancer, and people should pay more attention to thyroid cancer through health education so as to avoid exposure of related risk factors.
Objective: To study the risk factors related to thyroid cancer in Jiading District, Shanghai for providing evidence for the prevention and treatment of thyroid cancer. Methods: A total of 140 confirmed cases of thyroid cancer in Jiading District, Shanghai, from January 1, 2007 to December 30, 2016 were as a case group, including 42 males and 98 females, with an average age of(48.54±12.88) years. According to 1:1 matching, 140 cases of non thyroid cancer were recruited as a control group, including 42 males and 98 females, with an average age of(47.11±12.58) years old. A self-designed questionnaire was used to conduct the unified survey. Results: Univariate analysis results showed that there were statistically significant differences in body mass index, taste, edible marine animal food, edible preserved food, cooking and salting order, attitude, personality, marriage and life, staying up late, drinking tea, sulking and the family history of tumors between the case group and the control group(P<0.05). COX regression analysis showed that heavy taste, depression and family history of tumors were risk factors for thyroid cancer. Conclusion: Family history of tumors, heavy taste and love sulking are independent correlation of thyroid cancer, and people should pay more attention to thyroid cancer through health education so as to avoid exposure of related risk factors.
引文
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[2]Amacher AM,Goyal B,Lewis JJ,et al.Prevalence of a hobnail pattern inpapillary,poorly differentiated,and anaplasticthyroid carcinoma:a possible manifestation of highgrade transformation[J].Am J Surg Pathol,2015,39(2):260-265.
[3]翟建敏,原韶玲.甲状腺癌危险因素研究进展[J].中华肿瘤防治杂志,2012,21(10):791-795.
[4]Yaghoobi R,Ranjbari N,Derakhshandeh V,et al.Skin metastasis as the initialmanifestation of poorly differentiated thyroid carcinoma[J].Acta Dermatovenerol Croat,2014,22(3):218-220.
[5]高正衡.甲状腺癌44例临床分析[J].中国社区医师:医学专业,2012,9(5):97-98
[6]Ilias I,Alevizaki M,Lakka PE.Differentiated thyroid cancer in Greece:1963-2000.Relation to demographic and environmental factors[J].Hormones(Athens),2002,l:174-178.
[7]吕艳艳,朱本章.碘摄入和甲状腺癌发病率[J].国外医学地理分册,2008,29(1)33-34.
[8]关海霞,祭美菊,宝荣,等.高碘摄入与甲状腺乳头状癌中BRAF突变的关系[C].2008内分泌代谢性疾病系列研讨会暨中青年英文论坛论文汇编,哈尔滨:中华医学会内分泌学分会,2008:156-162.
[9]罗胜兰,俞敏,龚巍巍.甲状腺癌的流行现况及其危险因素[J].中国预防医学杂志,2013,11(4):317-322.
[10]韩俊庆,俞新爽,刘奇.甲状腺疾病与乳腺癌的关系[J].实用肿瘤学杂志,2008,22(1):265-272.