甲硫咪唑、丙硫氧嘧啶治疗甲状腺功能亢进的临床效果和安全性对比研究
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摘要
目的:观察甲硫咪唑、丙硫氧嘧啶在甲状腺功亢进中的应用效果,及两种药物的安全性情况。方法:随机选取2017年11月-2018年11月我院接收的78例甲状腺功能亢进的患者,根据治疗方法的差异性,将上述患者平均归纳为观察组与对照组,各39例。对照组为丙硫氧嘧啶治疗,观察组为甲硫咪唑治疗。结果:两组治疗前甲状腺功能指标比较无统计意义(P>0.05);两组治疗后甲状腺功能指标比较差异显著(P<0.05)。两组治疗后不良反应发生率比较差异无统计意义(P>0.05)。两组治疗效果的比较差异显著(P<0.05)。结论:甲硫咪唑和丙硫氧嘧啶对甲状腺功能亢进具有一定效果,均可实现对不良反应的控制,但甲硫咪唑对甲状腺功能指标的改善效果更好,能够提高疾病治疗效果,临床应用价值显著,可应用于临床。
Objective:To observe the effect of methylthimidazole and propylthiouracil in the treatment of hyperthyroidism and the safety of the two drugs. Methods:78 patients with hyperthyroidism received in our hospital from November 2017 to November 2018 were randomly selected. According to the difference of treatment methods,the above patients were divided into observation group and control group,39 cases each. The control group was treated with propylthiouracil and the observation group was treated with methimazole. Results:There was no statistical significance in thyroid function indexes before treatment between the two groups(P>0.05),and there was significant difference in thyroid function indexes after treatment between the two groups(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups after treatment(P>0.05). There was a significant difference between the two groups(P<0.05). Conclusion:Methimidazole and propylthiouracil have certain effects on hyperthyroidism and can control adverse reactions. However,methimidazole has better effect on improving thyroid function and can improve the therapeutic effect of diseases. It has significant clinical value and can be applied in clinic.
Objective:To observe the effect of methylthimidazole and propylthiouracil in the treatment of hyperthyroidism and the safety of the two drugs. Methods:78 patients with hyperthyroidism received in our hospital from November 2017 to November 2018 were randomly selected. According to the difference of treatment methods,the above patients were divided into observation group and control group,39 cases each. The control group was treated with propylthiouracil and the observation group was treated with methimazole. Results:There was no statistical significance in thyroid function indexes before treatment between the two groups(P>0.05),and there was significant difference in thyroid function indexes after treatment between the two groups(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups after treatment(P>0.05). There was a significant difference between the two groups(P<0.05). Conclusion:Methimidazole and propylthiouracil have certain effects on hyperthyroidism and can control adverse reactions. However,methimidazole has better effect on improving thyroid function and can improve the therapeutic effect of diseases. It has significant clinical value and can be applied in clinic.
引文
[1]沈玉国,仝淼,王晓剑,等.甲巯咪唑和丙硫氧嘧啶对甲状腺功能亢进症患者的疗效及对肝功能的影响[J].医学综述,2016,22(17):3472.
[2]白小岗,庞静,呼双琴,等.甲巯咪唑与丙硫氧嘧啶治疗甲亢的临床疗效和安全性对比研究[J].贵州医药,2017,23(09):51.
[3] Pearce EN. Management of thyrotoxicosis:Preconception,pregnancy,and the postpartum period[J]. Endocr Pract. 2019,25(1):62.
[4]熊慧丽,周庆元,赵晓宏,等.甲巯咪唑联合131I治疗甲状腺功能亢进的疗效及安全性分析[J].药物评价研究,2017,26(2):245.
[5]符宝林,符星.甲巯咪唑与丙硫氧嘧啶对甲状腺功能亢进患者肝功能影响的临床对照研究[J].药物评价研究,2017,25(4):545.
[6]区岛良,杨祚明.甲巯咪唑治疗绝经前甲状腺功能亢进的临床研究及其对免疫功能的影响[J].中国临床药理学杂志,2016,32(12):1094.
[7] Park S I,Lee Y J,Choi S H,et al. Therapeutic Effects of Blue Honeysuckle on Lesions of Hyperthyroidism in Rats[J]. The American Journal of Chinese Medicine,2016,44(07):1441.
[8]马亚萍.比较甲巯咪唑与丙硫氧嘧啶在治疗甲状腺功能亢进过程中对患者肝功能的影响[J].检验医学与临床,2017,14(Z1):221.
[9]钱玉兰,高杰.我院甲巯咪唑和丙硫氧嘧啶致不良反应60例分析[J].中国药房,2016,27(20):2783.
[10]牛荣,王建锋,晋建华,等.甲巯咪唑和丙硫氧嘧啶停药时间对正常大鼠甲状腺24h摄131I率的影响[J].中华核医学与分子影像杂志,2017,25(37):165.
[11]Fernando G P,Velasco-Martínez Pablo,Cristina A,et al. Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies[J]. Endocrinology, Diabetes&Metabolism Case Reports,2018,5:17
[12]储玲玲,杨文霞,何娟.耳穴贴压联合耳尖放血治疗甲状腺功能亢进的临床疗效与安全性分析[J].蚌埠医学院学报,2017,26(4):551.
[13]朱永宁,尹国才,谢宁,等.丙硫氧嘧啶治疗妊娠伴甲状腺功能亢进症对其甲状腺功能及新生儿的影响[J].疑难病杂志,2016,15(8):838.
[2]白小岗,庞静,呼双琴,等.甲巯咪唑与丙硫氧嘧啶治疗甲亢的临床疗效和安全性对比研究[J].贵州医药,2017,23(09):51.
[3] Pearce EN. Management of thyrotoxicosis:Preconception,pregnancy,and the postpartum period[J]. Endocr Pract. 2019,25(1):62.
[4]熊慧丽,周庆元,赵晓宏,等.甲巯咪唑联合131I治疗甲状腺功能亢进的疗效及安全性分析[J].药物评价研究,2017,26(2):245.
[5]符宝林,符星.甲巯咪唑与丙硫氧嘧啶对甲状腺功能亢进患者肝功能影响的临床对照研究[J].药物评价研究,2017,25(4):545.
[6]区岛良,杨祚明.甲巯咪唑治疗绝经前甲状腺功能亢进的临床研究及其对免疫功能的影响[J].中国临床药理学杂志,2016,32(12):1094.
[7] Park S I,Lee Y J,Choi S H,et al. Therapeutic Effects of Blue Honeysuckle on Lesions of Hyperthyroidism in Rats[J]. The American Journal of Chinese Medicine,2016,44(07):1441.
[8]马亚萍.比较甲巯咪唑与丙硫氧嘧啶在治疗甲状腺功能亢进过程中对患者肝功能的影响[J].检验医学与临床,2017,14(Z1):221.
[9]钱玉兰,高杰.我院甲巯咪唑和丙硫氧嘧啶致不良反应60例分析[J].中国药房,2016,27(20):2783.
[10]牛荣,王建锋,晋建华,等.甲巯咪唑和丙硫氧嘧啶停药时间对正常大鼠甲状腺24h摄131I率的影响[J].中华核医学与分子影像杂志,2017,25(37):165.
[11]Fernando G P,Velasco-Martínez Pablo,Cristina A,et al. Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies[J]. Endocrinology, Diabetes&Metabolism Case Reports,2018,5:17
[12]储玲玲,杨文霞,何娟.耳穴贴压联合耳尖放血治疗甲状腺功能亢进的临床疗效与安全性分析[J].蚌埠医学院学报,2017,26(4):551.
[13]朱永宁,尹国才,谢宁,等.丙硫氧嘧啶治疗妊娠伴甲状腺功能亢进症对其甲状腺功能及新生儿的影响[J].疑难病杂志,2016,15(8):838.