前列舒通联合坦洛新、左氧氟沙星治疗慢性骨盆疼痛综合征的疗效分析
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摘要
目的探讨前列舒通胶囊联合盐酸坦洛新缓释胶囊、左氧氟沙星治疗慢性骨盆疼痛综合征的临床疗效。方法 160例慢性骨盆疼痛综合征患者随机分成两组,治疗组和对照组,每组80人,治疗组采用前列舒通胶囊2.5 gpotid,盐酸坦洛新缓释胶囊0.2 mgpoqn,左氧氟沙星胶囊0.2 gpobid。对照组给予左氧氟沙星胶囊0.2gpobid,4周为1个疗程,治疗时间为8周。记录治疗过程中的前列腺液常规和NIH-CPSI评分变化。结果治疗组中80例治愈33例,治愈率41.3%,19例显效及有效,总有效率为65.0%;对照组中80例有17例治愈,治愈率21.25%,21例显效及有效,总有效率为47.0%。两组治愈率及总有效率相比,有明显差异,P<0.05,治疗组优于对照组。结论前列舒通胶囊联合盐酸坦洛新缓释胶囊和左氧氟沙星治疗慢性骨盆疼痛综合征有效,值得临床应用。
Objective: To evaluate the clinical efficacy of qianlieshutong capsule combined with tamsulosin hydrochloride sustained-release capsules and levofloxacin in treatment of CPPS. Methods: 160 patients with CPPS were randomly divided into treatment group( n = 80) and control group( n = 80). Patients in treatment group were treated with qianlieshutong 2.5 g po bid, Tamsulosin 0. 2 mg po qn, and levofloxasin 0.2 g po bid. The course of treatment was 4 weeks in two groups. The clinical efficacy and NIH-CPSI between the two groups were compared. Results: The effective rate of the treatment group(65.0%) was significantly higher than that of the control group(47.0%, P < 0. 05). Conclusion: The clinical efficacy of qianlieshutong combined with tamsulosin and levofloxacin in treatment of CPPS is effective, which is worth of clinical application.
Objective: To evaluate the clinical efficacy of qianlieshutong capsule combined with tamsulosin hydrochloride sustained-release capsules and levofloxacin in treatment of CPPS. Methods: 160 patients with CPPS were randomly divided into treatment group( n = 80) and control group( n = 80). Patients in treatment group were treated with qianlieshutong 2.5 g po bid, Tamsulosin 0. 2 mg po qn, and levofloxasin 0.2 g po bid. The course of treatment was 4 weeks in two groups. The clinical efficacy and NIH-CPSI between the two groups were compared. Results: The effective rate of the treatment group(65.0%) was significantly higher than that of the control group(47.0%, P < 0. 05). Conclusion: The clinical efficacy of qianlieshutong combined with tamsulosin and levofloxacin in treatment of CPPS is effective, which is worth of clinical application.
引文
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[2]Engeler D S,Baranowski A P,Dinis-Oliveira P,et al.Guidlines on cheonic Pelevc Pain[J].EurA Urol,2013,64(3):431-439.
[3]张文元,刘臻伟,康贻淦,等.腹腔镜下应用超声刀精索静脉高位结扎术115例的临床疗效分析[J].井冈山大学学报:自然科学版,2012,33(3):93-94.
[4]胡小鹏,白文俊,朱积川,等.慢性型前列腺炎细菌及免疫学研究[J].中华泌尿外科杂志,2002,23(1):29-31.
[5]Pontari M A,Ruggieri M R.Mechanisms in prostatitis/chronic pelvic pain syndrome[J].J Urol,2004,172(3):839-845.
[6]周占松,宋波,卢根生,等.前列腺、膀胱及盆底肌伤害感受神经元在脊髓中的分布及关系的研究[J].第三军医大学学报,2006,28(2):157-159.
[7]谢文杰,孙庭,杨晓荣,等.脑钠肽及其受体在慢性前列腺炎大鼠脊髓背角神经节中的表达[J].中华男科学杂志,2012,18(3):204-207.
[8]刘宾.慢性前列腺炎中医研究现状[J].世界中西医结合杂志,2009,4(9):672-673.
[9]李卫平,王养民,刘晟,等.盐酸坦洛新改善慢性前列腺炎/慢性盆腔疼痛综合征症状的疗效观察[J].医学研究杂志,2010,39(11):27-29.