水产品腐败菌群体感应系统及群体感应抑制剂研究进展
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摘要
群体感应(quorum sensing,QS)是一种微生物细胞间进行信息交流的系统。腐败菌的一些特性也受到QS系统的调控。在水产品保鲜领域,腐败菌的群体感应逐渐成为研究热点。本文中,笔者着重对水产品中微生物的群体感应作用机制、主要腐败菌的群体感应现象以及群体感应抑制剂等方面的研究进展进行概述,并对目前群体感应研究中所出现的问题及发展进行了总结及展望,旨在为以群体感应为基础的新型食品保鲜材料的开发提供参考。
Quorum sensing(QS)is a cell-to-cell communication system between microorganisms.Some characteristics of spoilage organisms are regulated by their QS system.QS has gradually become a research hotspot in the field of aquatic products preservation.In this article,we review recent progresses in mechanism of bacterial QS system,QS phenomenon of spoilage organisms of aquatic and quorum sensing inhibitors(QSIs).Furthermore,we summarize the problems and development in QS researches.We hope to provide a reference for the development of quorum sensing-based food preservation materials.
Quorum sensing(QS)is a cell-to-cell communication system between microorganisms.Some characteristics of spoilage organisms are regulated by their QS system.QS has gradually become a research hotspot in the field of aquatic products preservation.In this article,we review recent progresses in mechanism of bacterial QS system,QS phenomenon of spoilage organisms of aquatic and quorum sensing inhibitors(QSIs).Furthermore,we summarize the problems and development in QS researches.We hope to provide a reference for the development of quorum sensing-based food preservation materials.
引文
[1] ZHAO J,LI J,WANG J,et al.Applying different methods to evaluate the freshness of large yellow croacker (Pseudosciaena crocea) fillets during chilled storage[J].J Agric Food Chem,2012,60(45):11387-11394.
[2] 沈月新.水产食品学[M].北京:中国农业出版社,2000.
[3] DAVID K,PERSIS S.The stability and shelf-life of food[M].England:Woodhead publishing limited,2000.
[4] GINZINGER D G.Gene quantification using real-time quantitative PCR:an emerging technology hits the mainstream[J].Exp Hematol,2002,30(6):503-512.
[5] JAFFRèS E,LALANNE V,MACé S,et al.Sensory characteristics of spoilage and volatile compounds associated with bacteria isolated from cooked and peeled tropical shrimps using SPME-GC-MS analysis[J].Int J Food Microbiol,2011,147(3):195-202.
[6] ALFARO B,HERNANDEZ I.Evolution of the indigenous microbiota in modified atmosphere packaged Atlantic horse mackerel (Trachurus trachurus) identified by conventional and molecular methods[J].Int J Food Microbiol,2013,167(2):117-123.
[7] FONNESBECH V B,VENKATESWARAN K,SATOMI M,et al.Identification of Shewanella baltica as the most important H2S-producing species during iced storage of Danish marine fish[J].Appl Environ Microbiol,2005,71(11):6689-6697.
[8] GORNIK S G,ALBALAT A,MACPHERSON H,et al.The effect of temperature on the bacterial load and microbial composition in Norway lobster (Nephrops norvegicus) tail meat during storage[J].J Appl Microbiol,2011,111(3):582-592.
[9] SABRINA M,JOSIANE C,FRéDéRIQUE C,et al.Characterisation of the spoilage microbiota in raw salmon(Salmo salar)steaks stored under vacuum or modified atmosphere packaging combining conventional methods and PCR-TTGE[J].Food Microbiol,2012,30(1):164-172.
[10] FEDERLE M J,BASSLER B L.Interspecies communication in bacteria[J].J Clin Invest,2003,112(9):1291-1299.
[11] WANG B,MUIR T W.Regulation of virulence in Staphylococcus aureus:molecular mechanisms and remaining puzzles[J].Cell Chem Biol,2016,23:214-224.
[12] DRESCHER K,DUNKEL J,NADELL C D,et al.Architectural transitions in Vibrio cholerae biofilms at single-cell resolution[J].PNAS,2016,113(14):E2066-E2072.
[13] DANDEKAR A A,CHUGANI S,GREENBERG E P.Bacterial quorum sensing and metabolic incentives to cooperate[J].Science,2012,338:264-266.
[14] SKANDAMIS P N,NYCHAS G J.Quorum sensing in the context of food microbiology[J].Appl Environ Microbiol,2012,78(16):5473-5482.
[15] KAI P,SILPE J E,SCHRAMMA K R,et al.A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation[J].Nat Chem Biol,2017,13(5):551-557.
[16] BASSLER B L,LOSICK R.Bacterially speaking[J].Cell,2006,125(2):237-246.
[17] KIM H S,LEE S H,BYUN Y,et al.6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition[J].Sci Rep,2015,5:8656.
[18] AHUMEDO M,DIAZ A,VIVAS-REYES R.Theoretical and structural analysis of the active site of the transcriptional regulators LasR and TraR,using molecular docking methodology for identifying potential analogues of acyl homoserine lactones(AHLs)with anti-quorum sensing activity[J].Eur J Med Chem,2010,45:608-615.
[19] WANG Y,YI L,WANG S,et al.Crystal structure and identification of two key amino acids involved in AI-2 production and biofilm formation in Streptococcus suis LuxS[J].PLoS ONE,2015,10:e0138826.
[20] WHITELEY M,DIGGLE S P,GREENBERG E P.Progress in and promise of bacterial quorum sensing research[J].Nature,2017,551:313-320.
[21] FUQUA W C,WINANS S C,GREENBERG E P.Quorum sensing in bacteria:the LuxR-LuxI family of cell density-responsive transcriptional regulators[J].J Bacteriol,1994,176(2):269-275.
[22] POPAT R,CRUSZ S A,MESSINA M,et al.Quorum-sensing and cheating in bacterial biofilms[J].Proc Royal Soc B Biolog Sci,2012,279:4765-4771.
[23] WATSON W T,MINOGUE T D,VAL D L,et al.Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing[J].Mol Cell,2002,9(3):685-694.
[24] LEE J,ZHANG L.The hierarchy quorum sensing network in Pseudomonas aeruginosa[J].Protein Cell,2015,6(1):26-41.
[25] 王飞飞.基于DKP-LuxR的群体感应系统对Shewanella baltica腐败能力以及菌膜形成的调控研究[D].杭州:浙江工商大学,2018.
[26] PAPENFORT K,BASSLER B L.Quorum sensing signal-response systems in gram-negative bacteria[J].Nat Rev Microbiol,2016,14(9):576.
[27] ZHAO J,QUAN C,JIN L,et al.Production,detection and application perspectives of quorum sensing autoinducer-2 in bacteria[J].J Biotechnol,2018,268:53-60.
[28] 叶晓锋.大黄鱼源Shewanella baltica群体感应LuxS蛋白及cyclo-(L-Pro-L-Leu)信号分子功能研究[D].杭州:浙江工商大学,2017.
[29] 朱素芹.冷藏凡纳滨对虾特定腐败菌群体感应现象与致腐能力的研究[D].青岛:中国海洋大学,2015.
[30] BOYEN F,EECKHAUT V,IMMERSEEL F.V,et al.Quorum sensing in veterinary pathogens:mechanisms,clinical importance and future perspectives[J].Veter Microbiol,2009,135(3/4):187-195.
[31] SYVITSKI R T,TIAN X L,SAMPARA K,et al.Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans [J].J Bacteriol,2007,189(4):1441-1450.
[32] VERBEKE F,DE C S,DEBUNNE N,et al.Peptides as quorum sensing molecules:measurement techniques and obtained levels in vitro and in vivo[J].Front Neurosci,2017,11:183-215.
[33] 许振伟,杨宪时.鱼类腐败菌腐败能力的研究进展[J].湖南农业科学,2010(19):130-133.
[34] 赵二科,朱军莉,冯立芳,等.冷藏大黄鱼 SSO 希瓦氏菌致腐能力差异机制初探[J].水产学报,2015(2):256-264.
[35] 朱军莉,赵二科,孙丽霞,等.冷藏大黄鱼腐败菌群和群体感应信号分子的动态变化规律[J].中国食品学报,2015(4):175-182.
[36] ZHU J,ZHAO A,FENG L,et al.Quorum sensing signals affect spoilage of refrigerated large yellow croaker (Pseudosciaena crocea) by Shewanella baltica[J].Int J Food Microbiol,2016,217:146-155.
[37] MILLER M B,BASSLER B L.Quorum sensing in bacteria[J].Ann Rev Microbiol,2001,55:165-199.
[38] MANGWANI N,DASH H R,CHAUHAN A,et al.Bacterial quorum sensing:functional features and potential applications in biotechnology[J].J Mol Microbiol Biotechnol,2012,22(4):215-227.
[39] FU L,WANG C,LIU N,et al.Quorum sensing system-regulated genes affect the spoilage potential of Shewanella baltica[J].Food Res Int,2018,107:1-9.
[40] LI T,WANG D,LIU N,et al.Inhibition of quorum sensing-controlled virulence factors and biofilm formation in Pseudomonas fluorescens by cinnamaldehyde[J].Int J Food Microbiol,2018,269:98-106.
[41] LIU X,JI L,WANG X,et al.Role of RpoS in stress resistance,quorum sensing and spoilage potential of Pseudomonas fluorescens [J].Int J Food Microbiol,2018,270:31-38.
[42] 郭闯,朱国强,王永坤,等.14株患病水生动物气单胞菌属细菌的分离鉴定与最佳治疗药物筛选试验[J].水产科学,2003,22(4):14-17.
[43] 张翠娟,于宙亮,赵宝华,等.嗜水气单胞菌研究进展[J].中国兽药杂志,2008,42(7):46-50.
[44] 李婷婷,杨兵,励建荣.一株嗜水气单胞菌的分离鉴定和不同条件对其群体感应AHLs活性的影响[J].现代食品科技,2016(2):12-18.
[45] GALLOWAY W R J D,HODGKINSON J T,BOWDEN S,et al.Applications of small molecule activators and inhibitors of quorum sensing in gram-negative bacteria[J].Trends Microbiol,2012,20(9):449-458.
[46] 李学鹏,陈桂芳,仪淑敏,等.基于群体感应研究丹皮提取物对嗜水气单胞菌致腐性的抑制作用[J].中国食品学报,2018(3):196-204.
[47] CHAN X Y,HOW K Y,YIN W F,et al.N-acyl homoserine lactone-mediated quorum sensing in Aeromonas veronii biovar Sobria strain 159:identification of LuxR I homologs[J].Front Cell Infect Microbiol,2016,6:7.
[48] 梅永超,李婷婷,刘楠,等.绿薄荷精油对温和气单胞菌群体感应现象及其腐败特性的抑制作用[J].食品科学,2018,39(15):17-23.
[49] 马艳,李婷婷,崔方超,等.不同培养条件及群体感应信号分子对蜂房哈夫尼亚菌生物被膜的影响[J].食品科学,2017,38(6):42-47.
[50] VIANA E S,CAMPOS M E M,PONCE A R,et al.Biofilm formation and acyl homoserine lactone production in Hafnia alvei isolated from raw milk[J].Biol Res,2009,42(4):427-436.
[51] HOU H M,ZHU Y L,WANG J Y,,et al.Characteristics of n-acylhomoserine lactones produced by Hafnia alvei h4 isolated from spoiled instant sea cucumber[J].Sensors,2017,17(4):772.
[52] SAURAV K,COSTANTINO V,VENTURI V,et al.Quorum sensing inhibitors from the sea discovered using bacterial N-acyl-homoserine lactone-based biosensors[J].Mar Drugs,2017,15(3):53.
[53] 程古月,赫海红,戴梦红,等.病原菌的群体感应及其抑制剂的研究进展[J].科学通报,2012,57(21):1964-1977.
[54] KALIA V C,PUROHIT H J.Quenching the quorum sensing system:potential antibacterial drug targets[J].Crit Rev Microbiol,2011,37(2):121-140.
[55] MA L,LIU X,LIANG H,et al.Effects of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa[J].Antimicrob Agents Chemother,2012,56(12):6088-6094.
[56] GOPU V,MEENA C K,SHETTY P H.Quercetin influences quorum sensing in food borne bacteria:in vitro and in silico evidence[J].PLoS ONE,2015,10(8):e0134684.
[57] KUMAR L,CHHIBBER S,KUMAR R,et al.Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa[J].Fitoterapia,2015,102:84-95.
[58] HOANG T T,SCHWEIZER H P.Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase(FabI):a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis[J].J Bacteriol,1999,181(17):5489-5497.
[59] DU Y,LI T,WAN Y,et al.Signal molecule-dependent quorum-sensing and quorum-quenching enzymes in bacteria[J].Crit Rev Eukary Gene Exp,2014,24(2):117-132.
[60] 励建荣,杨兵,李婷婷.水产品优势腐败菌及其群体感应系统研究进展[J].食品科学,2015,36(19):255-259.
[61] 郭嘉亮,陈卫民.细菌群体感应信号分子与抑制剂研究进展[J].生命科学,2007,19(2):224-232.
[62] VATTEM D A,MIHALIK K,CRIXELL S H,et al.Dietary phytochemicals as quorum sensing inhibitors[J].Fitoterapia,2007,78(4):302-310.
[63] GIRENNAVAR B,CEPEDA M L,SONI K A,et al.Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria[J].Int J Food Microbiol,2008,125(2):204-208.
[64] GONZALEZ J E,KESHAVAN N D.Messing with bacterial quorum sensing[J].Microbiol Mol Biol Rev,2006,70:859-875.
[65] VIKRAM A,JESUDHASAN P R,JAYAPRAKASHA G K,et al.Citrus limonoids interfere with Vibrio harveyi cell-cell signalling and biofilm formation by modulating the response regulator LuxO[J].Microbiology,2011,157(1):99-110.
[66] ZHU H,SUN S J.Inhibition of bacterial quorum sensing-regulated behaviors by Tremella fuciformis extract[J].Curr Microbiol,2008,57(5):418-422.
[67] ZHU H,HE C C,CHU Q H.Inhibition of quorum sensing in Chromobacterium violaceum by pigments extracted from Auricularia auricular [J].Lett Appl Microbiol,2011,52(3):269-274.
[68] BOSGELMEZ-TINAZ G,ULUSOY S,UGUR A,et al.Inhibition of quorum sensing-regulated behaviors by Scorzonera sandrasica[J].Curr Microbiol,2007,55(2):114-118.
[69] CHOO J H,RUKAYADI Y,HWANG J K.Inhibition of bacterial quorum sensing by vanilla extract[J].Lett Appl Microbiol,2006,42(6):637-641.
[70] ZHANG J M,RUI X,WANG L,et al.Polyphenolic extract from Rosa rugosa tea inhibits bacterial quorum sensing and biofilm formation[J].Food Control,2014,42:125-131.
[71] PACKIAVATHY I A,PRIYA S,PANDIAN S K,et al.Inhibition of biofilm development of uropathogens by curcumin:an anti-quorum sensing agent from Curcuma longa[J].Food Chem,2014,148:453-460.
[72] ZHU S,WU H,ZENG M,et al.The involvement of bacterial quorum sensing in the spoilage of refrigerated Litopenaeus vannamei[J].Int J Food Microbiol,2015,192:26-33.
[73] GHOUL M,WEST S A,DIGGLE S P,et al.An experimental test of whether cheating is context dependent[J].J Evolut Biol,2014,27(3):551-556.
[74] ZENG Z,QIAN L,CAO L,et al.Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa [J].Appl Microbiol Biotechnol,2008,79(1):119-126.
[75] DING T,LI T,ZHI W,et al.Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis[J].Sci Rep,2017,7(1):8612.
[76] DEFOIRDT T,BRACKMAN G,COENYE T,et al.Quorum sensing inhibitors:how strong is the evidence[J].Trends Microbiol,2013,21(12):619-624.
[2] 沈月新.水产食品学[M].北京:中国农业出版社,2000.
[3] DAVID K,PERSIS S.The stability and shelf-life of food[M].England:Woodhead publishing limited,2000.
[4] GINZINGER D G.Gene quantification using real-time quantitative PCR:an emerging technology hits the mainstream[J].Exp Hematol,2002,30(6):503-512.
[5] JAFFRèS E,LALANNE V,MACé S,et al.Sensory characteristics of spoilage and volatile compounds associated with bacteria isolated from cooked and peeled tropical shrimps using SPME-GC-MS analysis[J].Int J Food Microbiol,2011,147(3):195-202.
[6] ALFARO B,HERNANDEZ I.Evolution of the indigenous microbiota in modified atmosphere packaged Atlantic horse mackerel (Trachurus trachurus) identified by conventional and molecular methods[J].Int J Food Microbiol,2013,167(2):117-123.
[7] FONNESBECH V B,VENKATESWARAN K,SATOMI M,et al.Identification of Shewanella baltica as the most important H2S-producing species during iced storage of Danish marine fish[J].Appl Environ Microbiol,2005,71(11):6689-6697.
[8] GORNIK S G,ALBALAT A,MACPHERSON H,et al.The effect of temperature on the bacterial load and microbial composition in Norway lobster (Nephrops norvegicus) tail meat during storage[J].J Appl Microbiol,2011,111(3):582-592.
[9] SABRINA M,JOSIANE C,FRéDéRIQUE C,et al.Characterisation of the spoilage microbiota in raw salmon(Salmo salar)steaks stored under vacuum or modified atmosphere packaging combining conventional methods and PCR-TTGE[J].Food Microbiol,2012,30(1):164-172.
[10] FEDERLE M J,BASSLER B L.Interspecies communication in bacteria[J].J Clin Invest,2003,112(9):1291-1299.
[11] WANG B,MUIR T W.Regulation of virulence in Staphylococcus aureus:molecular mechanisms and remaining puzzles[J].Cell Chem Biol,2016,23:214-224.
[12] DRESCHER K,DUNKEL J,NADELL C D,et al.Architectural transitions in Vibrio cholerae biofilms at single-cell resolution[J].PNAS,2016,113(14):E2066-E2072.
[13] DANDEKAR A A,CHUGANI S,GREENBERG E P.Bacterial quorum sensing and metabolic incentives to cooperate[J].Science,2012,338:264-266.
[14] SKANDAMIS P N,NYCHAS G J.Quorum sensing in the context of food microbiology[J].Appl Environ Microbiol,2012,78(16):5473-5482.
[15] KAI P,SILPE J E,SCHRAMMA K R,et al.A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation[J].Nat Chem Biol,2017,13(5):551-557.
[16] BASSLER B L,LOSICK R.Bacterially speaking[J].Cell,2006,125(2):237-246.
[17] KIM H S,LEE S H,BYUN Y,et al.6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition[J].Sci Rep,2015,5:8656.
[18] AHUMEDO M,DIAZ A,VIVAS-REYES R.Theoretical and structural analysis of the active site of the transcriptional regulators LasR and TraR,using molecular docking methodology for identifying potential analogues of acyl homoserine lactones(AHLs)with anti-quorum sensing activity[J].Eur J Med Chem,2010,45:608-615.
[19] WANG Y,YI L,WANG S,et al.Crystal structure and identification of two key amino acids involved in AI-2 production and biofilm formation in Streptococcus suis LuxS[J].PLoS ONE,2015,10:e0138826.
[20] WHITELEY M,DIGGLE S P,GREENBERG E P.Progress in and promise of bacterial quorum sensing research[J].Nature,2017,551:313-320.
[21] FUQUA W C,WINANS S C,GREENBERG E P.Quorum sensing in bacteria:the LuxR-LuxI family of cell density-responsive transcriptional regulators[J].J Bacteriol,1994,176(2):269-275.
[22] POPAT R,CRUSZ S A,MESSINA M,et al.Quorum-sensing and cheating in bacterial biofilms[J].Proc Royal Soc B Biolog Sci,2012,279:4765-4771.
[23] WATSON W T,MINOGUE T D,VAL D L,et al.Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing[J].Mol Cell,2002,9(3):685-694.
[24] LEE J,ZHANG L.The hierarchy quorum sensing network in Pseudomonas aeruginosa[J].Protein Cell,2015,6(1):26-41.
[25] 王飞飞.基于DKP-LuxR的群体感应系统对Shewanella baltica腐败能力以及菌膜形成的调控研究[D].杭州:浙江工商大学,2018.
[26] PAPENFORT K,BASSLER B L.Quorum sensing signal-response systems in gram-negative bacteria[J].Nat Rev Microbiol,2016,14(9):576.
[27] ZHAO J,QUAN C,JIN L,et al.Production,detection and application perspectives of quorum sensing autoinducer-2 in bacteria[J].J Biotechnol,2018,268:53-60.
[28] 叶晓锋.大黄鱼源Shewanella baltica群体感应LuxS蛋白及cyclo-(L-Pro-L-Leu)信号分子功能研究[D].杭州:浙江工商大学,2017.
[29] 朱素芹.冷藏凡纳滨对虾特定腐败菌群体感应现象与致腐能力的研究[D].青岛:中国海洋大学,2015.
[30] BOYEN F,EECKHAUT V,IMMERSEEL F.V,et al.Quorum sensing in veterinary pathogens:mechanisms,clinical importance and future perspectives[J].Veter Microbiol,2009,135(3/4):187-195.
[31] SYVITSKI R T,TIAN X L,SAMPARA K,et al.Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans [J].J Bacteriol,2007,189(4):1441-1450.
[32] VERBEKE F,DE C S,DEBUNNE N,et al.Peptides as quorum sensing molecules:measurement techniques and obtained levels in vitro and in vivo[J].Front Neurosci,2017,11:183-215.
[33] 许振伟,杨宪时.鱼类腐败菌腐败能力的研究进展[J].湖南农业科学,2010(19):130-133.
[34] 赵二科,朱军莉,冯立芳,等.冷藏大黄鱼 SSO 希瓦氏菌致腐能力差异机制初探[J].水产学报,2015(2):256-264.
[35] 朱军莉,赵二科,孙丽霞,等.冷藏大黄鱼腐败菌群和群体感应信号分子的动态变化规律[J].中国食品学报,2015(4):175-182.
[36] ZHU J,ZHAO A,FENG L,et al.Quorum sensing signals affect spoilage of refrigerated large yellow croaker (Pseudosciaena crocea) by Shewanella baltica[J].Int J Food Microbiol,2016,217:146-155.
[37] MILLER M B,BASSLER B L.Quorum sensing in bacteria[J].Ann Rev Microbiol,2001,55:165-199.
[38] MANGWANI N,DASH H R,CHAUHAN A,et al.Bacterial quorum sensing:functional features and potential applications in biotechnology[J].J Mol Microbiol Biotechnol,2012,22(4):215-227.
[39] FU L,WANG C,LIU N,et al.Quorum sensing system-regulated genes affect the spoilage potential of Shewanella baltica[J].Food Res Int,2018,107:1-9.
[40] LI T,WANG D,LIU N,et al.Inhibition of quorum sensing-controlled virulence factors and biofilm formation in Pseudomonas fluorescens by cinnamaldehyde[J].Int J Food Microbiol,2018,269:98-106.
[41] LIU X,JI L,WANG X,et al.Role of RpoS in stress resistance,quorum sensing and spoilage potential of Pseudomonas fluorescens [J].Int J Food Microbiol,2018,270:31-38.
[42] 郭闯,朱国强,王永坤,等.14株患病水生动物气单胞菌属细菌的分离鉴定与最佳治疗药物筛选试验[J].水产科学,2003,22(4):14-17.
[43] 张翠娟,于宙亮,赵宝华,等.嗜水气单胞菌研究进展[J].中国兽药杂志,2008,42(7):46-50.
[44] 李婷婷,杨兵,励建荣.一株嗜水气单胞菌的分离鉴定和不同条件对其群体感应AHLs活性的影响[J].现代食品科技,2016(2):12-18.
[45] GALLOWAY W R J D,HODGKINSON J T,BOWDEN S,et al.Applications of small molecule activators and inhibitors of quorum sensing in gram-negative bacteria[J].Trends Microbiol,2012,20(9):449-458.
[46] 李学鹏,陈桂芳,仪淑敏,等.基于群体感应研究丹皮提取物对嗜水气单胞菌致腐性的抑制作用[J].中国食品学报,2018(3):196-204.
[47] CHAN X Y,HOW K Y,YIN W F,et al.N-acyl homoserine lactone-mediated quorum sensing in Aeromonas veronii biovar Sobria strain 159:identification of LuxR I homologs[J].Front Cell Infect Microbiol,2016,6:7.
[48] 梅永超,李婷婷,刘楠,等.绿薄荷精油对温和气单胞菌群体感应现象及其腐败特性的抑制作用[J].食品科学,2018,39(15):17-23.
[49] 马艳,李婷婷,崔方超,等.不同培养条件及群体感应信号分子对蜂房哈夫尼亚菌生物被膜的影响[J].食品科学,2017,38(6):42-47.
[50] VIANA E S,CAMPOS M E M,PONCE A R,et al.Biofilm formation and acyl homoserine lactone production in Hafnia alvei isolated from raw milk[J].Biol Res,2009,42(4):427-436.
[51] HOU H M,ZHU Y L,WANG J Y,,et al.Characteristics of n-acylhomoserine lactones produced by Hafnia alvei h4 isolated from spoiled instant sea cucumber[J].Sensors,2017,17(4):772.
[52] SAURAV K,COSTANTINO V,VENTURI V,et al.Quorum sensing inhibitors from the sea discovered using bacterial N-acyl-homoserine lactone-based biosensors[J].Mar Drugs,2017,15(3):53.
[53] 程古月,赫海红,戴梦红,等.病原菌的群体感应及其抑制剂的研究进展[J].科学通报,2012,57(21):1964-1977.
[54] KALIA V C,PUROHIT H J.Quenching the quorum sensing system:potential antibacterial drug targets[J].Crit Rev Microbiol,2011,37(2):121-140.
[55] MA L,LIU X,LIANG H,et al.Effects of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa[J].Antimicrob Agents Chemother,2012,56(12):6088-6094.
[56] GOPU V,MEENA C K,SHETTY P H.Quercetin influences quorum sensing in food borne bacteria:in vitro and in silico evidence[J].PLoS ONE,2015,10(8):e0134684.
[57] KUMAR L,CHHIBBER S,KUMAR R,et al.Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa[J].Fitoterapia,2015,102:84-95.
[58] HOANG T T,SCHWEIZER H P.Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase(FabI):a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis[J].J Bacteriol,1999,181(17):5489-5497.
[59] DU Y,LI T,WAN Y,et al.Signal molecule-dependent quorum-sensing and quorum-quenching enzymes in bacteria[J].Crit Rev Eukary Gene Exp,2014,24(2):117-132.
[60] 励建荣,杨兵,李婷婷.水产品优势腐败菌及其群体感应系统研究进展[J].食品科学,2015,36(19):255-259.
[61] 郭嘉亮,陈卫民.细菌群体感应信号分子与抑制剂研究进展[J].生命科学,2007,19(2):224-232.
[62] VATTEM D A,MIHALIK K,CRIXELL S H,et al.Dietary phytochemicals as quorum sensing inhibitors[J].Fitoterapia,2007,78(4):302-310.
[63] GIRENNAVAR B,CEPEDA M L,SONI K A,et al.Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria[J].Int J Food Microbiol,2008,125(2):204-208.
[64] GONZALEZ J E,KESHAVAN N D.Messing with bacterial quorum sensing[J].Microbiol Mol Biol Rev,2006,70:859-875.
[65] VIKRAM A,JESUDHASAN P R,JAYAPRAKASHA G K,et al.Citrus limonoids interfere with Vibrio harveyi cell-cell signalling and biofilm formation by modulating the response regulator LuxO[J].Microbiology,2011,157(1):99-110.
[66] ZHU H,SUN S J.Inhibition of bacterial quorum sensing-regulated behaviors by Tremella fuciformis extract[J].Curr Microbiol,2008,57(5):418-422.
[67] ZHU H,HE C C,CHU Q H.Inhibition of quorum sensing in Chromobacterium violaceum by pigments extracted from Auricularia auricular [J].Lett Appl Microbiol,2011,52(3):269-274.
[68] BOSGELMEZ-TINAZ G,ULUSOY S,UGUR A,et al.Inhibition of quorum sensing-regulated behaviors by Scorzonera sandrasica[J].Curr Microbiol,2007,55(2):114-118.
[69] CHOO J H,RUKAYADI Y,HWANG J K.Inhibition of bacterial quorum sensing by vanilla extract[J].Lett Appl Microbiol,2006,42(6):637-641.
[70] ZHANG J M,RUI X,WANG L,et al.Polyphenolic extract from Rosa rugosa tea inhibits bacterial quorum sensing and biofilm formation[J].Food Control,2014,42:125-131.
[71] PACKIAVATHY I A,PRIYA S,PANDIAN S K,et al.Inhibition of biofilm development of uropathogens by curcumin:an anti-quorum sensing agent from Curcuma longa[J].Food Chem,2014,148:453-460.
[72] ZHU S,WU H,ZENG M,et al.The involvement of bacterial quorum sensing in the spoilage of refrigerated Litopenaeus vannamei[J].Int J Food Microbiol,2015,192:26-33.
[73] GHOUL M,WEST S A,DIGGLE S P,et al.An experimental test of whether cheating is context dependent[J].J Evolut Biol,2014,27(3):551-556.
[74] ZENG Z,QIAN L,CAO L,et al.Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa [J].Appl Microbiol Biotechnol,2008,79(1):119-126.
[75] DING T,LI T,ZHI W,et al.Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis[J].Sci Rep,2017,7(1):8612.
[76] DEFOIRDT T,BRACKMAN G,COENYE T,et al.Quorum sensing inhibitors:how strong is the evidence[J].Trends Microbiol,2013,21(12):619-624.