人体肠道微生物群与抑郁症的相关性研究进展
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摘要
抑郁症又称抑郁障碍,是一种常见的精神疾病,主要表现为情绪低落、悲观、思维迟缓、以及言语动作减少,迟缓等。抑郁症严重困扰患者的生活和工作,给家庭和社会带来沉重的负担,约15%的抑郁症患者死于自杀。肠道菌群作为寄居在人消化道内的大量微生物,是人体健康和疾病转换过程中的重要环境因素。肠-脑轴是联系大脑和胃肠功能的双向信息调节系统,肠道微生物在生理和病理条件下均能参与肠-脑轴活动,影响大脑功能和某些关联行为。因此,深入研究肠道微生物与抑郁症的相互作用,开发以肠道菌群为靶点的个性化药物,能够为抑郁症的临床预防和治疗提供新的研究思路和方法。
Depression,also called depressive disorder,is a common mental disorder,mainly manifested in depression,pessimism,thinking retardation,as well as speech reduction,retardation and so on. Depression seriously affects the life and work of patients and brings heavy burden to family and society. About 15% of depression patients die of suicide. As a large number of microorganisms living in human digestive tract,intestinal flora is an important environmental factor in the process of human health and disease transformation. The intestinal-brain axis is a two-way information regulation system that connects the brain and gastrointestinal function. Intestinal microbes can participate in the intestinal-brain axis activity under physiological and pathological conditions,and affect the brain function and some related lines. Therefore,it is possible to provide new ideas and methods for the clinical prevention and treatment of depression by studying the interaction between intestinal microorganisms and depression and developing personalized medicine taking intestinal flora as target.
Depression,also called depressive disorder,is a common mental disorder,mainly manifested in depression,pessimism,thinking retardation,as well as speech reduction,retardation and so on. Depression seriously affects the life and work of patients and brings heavy burden to family and society. About 15% of depression patients die of suicide. As a large number of microorganisms living in human digestive tract,intestinal flora is an important environmental factor in the process of human health and disease transformation. The intestinal-brain axis is a two-way information regulation system that connects the brain and gastrointestinal function. Intestinal microbes can participate in the intestinal-brain axis activity under physiological and pathological conditions,and affect the brain function and some related lines. Therefore,it is possible to provide new ideas and methods for the clinical prevention and treatment of depression by studying the interaction between intestinal microorganisms and depression and developing personalized medicine taking intestinal flora as target.
引文
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[29]FOSTER J A,NEUFELD KA MV.Gut-brain axis:how the microbiome influences anxiety and depression[J].Trends Neurosci,2013,36(5):305-312.
[30]ZHENG P,ZENG B,ZHOU C,et al.Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism[J].Molecular Psychiatry,2016,21(6):786-796.
[31]蒋海寅.人类肠道微生物群落菌群多样性变化与抑郁症的相关性研究[D].2015,浙江大学,博士学位论文.
[32]王来海.抑郁症治疗药物研究新进展[J].临床心身疾病杂志,2004,10(1):70-72.
[33]BERCIK P,PARK A J,SINCLAIR D,et al.The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication[J].Neurogastroenterol Motil,2011,23(12):1132-1139.
[34]陈青微,陈慧.逍遥散联合黛力新中西医结合治疗围绝经期抑郁症的临床观察.中国现代医生,2015,53(2):141-143.
[35]陈家旭,杨建新,赵歆,等.慢性束缚应激大鼠下丘脑β-内啡肽变化及中药复方对其的影响.中国医药学报,2004,19(2):83-85.
[2]DINAN T G,CRYAN J F.Melancholic microbes:a link between gut microbiota and depression[J].Neurogastroenterol Motil,2013,25(9):713-719.
[3]冯伟薇,李欣.肠道微生物对抑郁障碍影响的研究[J].世界最新医学信息文摘,2017,(5):26.
[4]WANG Y,KASPER L H.The role of microbiome in central nervous system disorders[J].Brain Behav Immun,2014,38:1-12.
[5]BELKAID Y,NAIK S.Compartmentalized and systemic control of tissue immunity by commensals[J].Nat Immunol,2013,14(7):646-653.
[6]刘丹英.双歧杆菌三联活菌散对儿童腹型过敏性紫癜患儿肠黏膜屏障的保护作用[J].中国微生态学杂志,2018,30(1):63-65.
[7]MEYER C,VASSAR M.The fragility of probiotic Bifidobacterium longum NCC3001 use for depression in patients with irritable bowel syndrome[J].Gastroenterology,2018,154(3):764.
[8]马丽娜,刘剑刚,李浩.肠道微生物与阿尔茨海默病的相关性研究进展[J].中国药理学通报,2017,33(7):893-896.
[9]AIT-BELGNAOUI A,PAYARD I,ROLLAND C,et al.Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation[J].J Neurogastroenterol Motil,2018,24(1):138-146.
[10]MYINT A M,O'MAHONY S,KUBERA M,et al.Role of paroxetine in interferon-alpha-induced immune and behavioural changes in male Wistar rats[J].J Psychopharmacol,2007,21(8):843-850.
[11]康安,郑啸,文红梅,等.炎症信号在脑-肠轴中的传递及药物干预机制研究进展[J].中国临床药理学与治疗学,2012,17(12):1407-1412.
[12]MATSUOKA K,UEMURA Y,KANAI T,et al.Efficacy of Bifidobacterium breve Fermented Milk in Maintaining Remission of Ulcerative Colitis[J].Dig Dis Sci,2018,63(7):1910-1919.
[13]DE PALMA G,COLLINS S M,BERCIK P.The microbiota-gutbrain axis in functional gastrointestinal disorders[J].Gut Microbes,2014,5(3):419-429.
[14]CARABOTTI M,SCIROCCO A,MASELLI M A,et al.The gutbrain axis:interactions between enteric microbiota,central and enteric nervous systems[J].Ann Gastroenterol,2015,28(2):203-209.
[15]DING X F,ZHAO X H,TAO Y,et al.Xiao Yao San Improves Depressive-Like Behaviors in Rats with Chronic Immobilization Stress through Modulation of Locus Coeruleus-Norepinephrine System[J].Evid Based Complement Alternat Med,2014:605914.
[16]KABOURIDIS P S,LASRADO R,MC CALLUM S,et al.Microbiota controls the homeostasis of glial cells in the gut lamina propria[J].Neuron,2015,85(2):289-295.
[17]RAO M,GERSHON M D.Bugs,guts,and glia:how microbiota influence enteric gliogenesis and migration[J].Neuron,2015,85(2):229-230.
[18]ROILG A S,MITTGE E K,GANZ J,et al.The enteric nervous system promotes intestinal health by constraining microbiota composition[J].PLo S Biol,2017,15(2):e2000689.
[19]RASKOV H,BURCHARTH J,POMMERGAARD H C,et al.Irritable bowel syndrome,the microbiota and the gut-brain axis[J].Gut Microbes,2016,7(5):365-383.
[20]POWELL N,WALKER M M,TALLEY N J.The mucosal immune system:master regulator of bidirectional gut-brain communications[J].Nat Rev Gastroenterol Hepatol,2017,14(3):143-159.
[21]JIANG H,LING Z,ZHANG Y,et al.Altered fecal microbiota composition in patients with major depressive disorder[J].Brain Behav Immun,2015,48(4):186-194.
[22]于周龙.肠道微生物与神经精神疾病的相关研究进展:第十四届全国药物依赖性学术会议暨国际精神疾病研讨会论文摘要汇编[C].北京:中国毒理学会,2016:2.
[23]GARDIER A M.Antidepressant activity:Contribution of brain microdialysis in knock-out mice to the understanding of BDNF/5-HT transporter/5-HT autoreceptor interactions[J].Front Pharmacol,2013,4:98.
[24]安锋利.多因素作用下的抑郁症机制研究进展[J].四川生理科学杂志,2016,38(2):95-100.
[25]PARK A J,COLLINS J,BLENNERHASSETT P A,et al.Altered colonic function and microbiota profile in a mouse model of chronic depression[J].Neurogastroenterol Motil,2013,25(9):733-740,e574-e575.
[26]许二平,许国防,苗明三,等.中医药治疗抑郁症研究进展[J].中医学报,2017,32(224):45-48.
[27]DUMAN R S,AGHAJANIAN G K.Synaptic dysfunction in depression:potential therapeutic targets[J].Science,2012,338(6103):68-72.
[28]ROOK G A,LOWRY C A.The hygiene hypothesis and psychiatric disorders[J].Trends immunol,2008,29(4):150-158.
[29]FOSTER J A,NEUFELD KA MV.Gut-brain axis:how the microbiome influences anxiety and depression[J].Trends Neurosci,2013,36(5):305-312.
[30]ZHENG P,ZENG B,ZHOU C,et al.Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism[J].Molecular Psychiatry,2016,21(6):786-796.
[31]蒋海寅.人类肠道微生物群落菌群多样性变化与抑郁症的相关性研究[D].2015,浙江大学,博士学位论文.
[32]王来海.抑郁症治疗药物研究新进展[J].临床心身疾病杂志,2004,10(1):70-72.
[33]BERCIK P,PARK A J,SINCLAIR D,et al.The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication[J].Neurogastroenterol Motil,2011,23(12):1132-1139.
[34]陈青微,陈慧.逍遥散联合黛力新中西医结合治疗围绝经期抑郁症的临床观察.中国现代医生,2015,53(2):141-143.
[35]陈家旭,杨建新,赵歆,等.慢性束缚应激大鼠下丘脑β-内啡肽变化及中药复方对其的影响.中国医药学报,2004,19(2):83-85.